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PDGF R alpha Products
PDGF R alpha (Platelet-Derived Growth Factor Receptor alpha) is a transmembrane receptor tyrosine kinase that can form homodimers or heterodimers with PDGF R beta when engaged by dimers of the PDGF ligands. PDGF R alpha binds to PDGF-AA, PDGF-AB, and PDGF-CC. It is strongly expressed in oligodendrocyte, lung, skin, and intestinal progenitor cells, at low levels in most mesenchymal cells, and can be induced by inflammation. PDGF R alpha function is important during formation of the cranial and cardiac neural crest, retina, gonads, lung alveoli, intestinal villi, skin, hair follicles, skeleton, teeth, palate, and interstitial kidney mesenchyme. Dysregulated PDGF R alpha signaling can result in spina bifida or cleft palate-type malformations. Postnatally, PDGF R alpha is implicated in gliomas and fibrotic disorders of lung, heart, and skin (scleroderma).
48 results for "PDGF R alpha" in Products
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PDGF R alpha Products
PDGF R alpha (Platelet-Derived Growth Factor Receptor alpha) is a transmembrane receptor tyrosine kinase that can form homodimers or heterodimers with PDGF R beta when engaged by dimers of the PDGF ligands. PDGF R alpha binds to PDGF-AA, PDGF-AB, and PDGF-CC. It is strongly expressed in oligodendrocyte, lung, skin, and intestinal progenitor cells, at low levels in most mesenchymal cells, and can be induced by inflammation. PDGF R alpha function is important during formation of the cranial and cardiac neural crest, retina, gonads, lung alveoli, intestinal villi, skin, hair follicles, skeleton, teeth, palate, and interstitial kidney mesenchyme. Dysregulated PDGF R alpha signaling can result in spina bifida or cleft palate-type malformations. Postnatally, PDGF R alpha is implicated in gliomas and fibrotic disorders of lung, heart, and skin (scleroderma).
48 results for "PDGF R alpha" in Products
| Clonality : | Polyclonal |
| Host : | Goat IgG |
| Applications : | Block/Neutralize, Immunohistochemistry, Western Blot |
Contains 4 membranes - each spotted in duplicate with 49 different RTK antibodies
Contains 4 membranes-each spotted in duplicate with 49 different antibodies to ubiquitin target proteins
Contains 4 membranes - each spotted in duplicate with 39 different RTK antibodies
Potent and selective v-Abl tyrosine kinase inhibitor; also inhibits PDGFR and c-kit
| Alternate Names : | Gleevec, CGP 57148B |
| Chemical Name : | 4-[(4-Methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]benzamide methanesulfonate |
| Purity : | ≥98% (HPLC) |
| Clonality : | Polyclonal |
| Host : | Goat IgG |
| Applications : | Block/Neutralize, Immunohistochemistry, Western Blot |
Potent PDGFRα and PDGFRβ inhibitor; also inhibits c-Abl, Lck, c-Src and Fyn kinases
| Chemical Name : | N-(3-Fluorophenyl)-1,4-dihydro-6,7-dimethoxyindeno[1,2-c]pyrazol-3-amine |
| Purity : | ≥98% (HPLC) |
| Applications : | ELISA |
Potent and selective PDGFR family inhibitor
| Chemical Name : | N-[4-[[[[5-(1,1-Dimethethylethyl)-3-isoxazolyl]amino]carbonyl]amino]phenyl]-5-[(1-ethyl-2,2,6,6-tetramethyl-4-piperidinyl)oxy]-2-pyridinecarboxamide |
| Purity : | ≥99% (HPLC) |
| Clonality : | Polyclonal |
| Host : | Goat IgG |
| Applications : | Flow Cytometry |
Recombinant Monoclonal Antibody For Research Use Only
| Clonality : | Monoclonal |
| Host : | Human IgG1 Clone #Hu136 |
| Applications : | CyTOF-ready, Flow Cytometry |
| Clonality : | Monoclonal |
| Host : | Rat IgG2b Clone #1039504 |
| Applications : | Immunocytochemistry/Immunofluorescence, Immunohistochemistry |
| Assay Range : | 312 - 20,000 pg/mL |
| Applications : | ELISA |
Potent inhibitor of VEGFR, PDGFR and FGFR
| Chemical Name : | 4-[(4-Fluoro-2-methyl-1H-indol-5-yl)oxy]-6-methoxy-7-[3-(1-pyrrolidinyl)propoxy]quinazoline |
| Purity : | ≥98% (HPLC) |
| Clonality : | Monoclonal |
| Host : | Rat IgG2a Clone #189208 |
| Applications : | Western Blot |
| Clonality : | Polyclonal |
| Host : | Goat IgG |
| Applications : | Western Blot |
Biotinylated
| Source : | HEK293 |
| Accession # : | P16234.1 |
| Applications : | Binding Activity |
| Clonality : | Polyclonal |
| Host : | Goat IgG |
| Applications : | Immunohistochemistry, Western Blot |
| Clonality : | Monoclonal |
| Host : | Mouse IgG1 Clone #PRa292 |
| Applications : | Flow Cytometry |
| Clonality : | Monoclonal |
| Host : | Mouse IgG1 Clone #35248 |
| Applications : | Block/Neutralize, Immunohistochemistry, Western Blot |
| Clonality : | Monoclonal |
| Host : | Mouse IgG1 Clone #PRa292 |
| Applications : | Flow Cytometry |
| Clonality : | Monoclonal |
| Host : | Mouse IgG1 Clone #PRa292 |
| Applications : | Flow Cytometry |
| Clonality : | Monoclonal |
| Host : | Mouse IgG1 Clone #PRa292 |
| Applications : | Flow Cytometry |
| Source : | NS0 |
| Accession # : | P16234 |
| Applications : | Bioactivity |
