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Insulin R/CD220 Products

Insulin Receptor (INSR, CD220) is a type I transmembrane glycoprotein in the Insulin/IGF Receptor family of receptor tyrosine kinases. The mature receptor contains an extracellular alpha subunit and an extracellular/transmembrane/cytoplasmic beta subunit. Alternative splicing generates A and B isoforms which may homodimerize or heterodimerize with the IGF-I receptor.

All receptor combinations bind Insulin, IGF-I, or IGF-II, but with differing affinities. Insulin R signaling regulates glucose uptake and metabolism but also contributes to cell growth, differentiation and apoptosis. Mutations in INSR have been linked to severe insulin resistance (type A and Rabson-Mendenhall syndrome), type II diabetes mellitus, and leprechaunism (Donohue syndrome).

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217 results for "Insulin R/CD220" in Products

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Insulin R/CD220 Products

Insulin Receptor (INSR, CD220) is a type I transmembrane glycoprotein in the Insulin/IGF Receptor family of receptor tyrosine kinases. The mature receptor contains an extracellular alpha subunit and an extracellular/transmembrane/cytoplasmic beta subunit. Alternative splicing generates A and B isoforms which may homodimerize or heterodimerize with the IGF-I receptor.

All receptor combinations bind Insulin, IGF-I, or IGF-II, but with differing affinities. Insulin R signaling regulates glucose uptake and metabolism but also contributes to cell growth, differentiation and apoptosis. Mutations in INSR have been linked to severe insulin resistance (type A and Rabson-Mendenhall syndrome), type II diabetes mellitus, and leprechaunism (Donohue syndrome).

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217 results for "Insulin R/CD220" in Products

BA

B Isoform

ELISA
Catalog #: FAB1544T
Flow
Catalog #: FAB1544U
Flow
Catalog #: RDC0878
Catalog #: RDC1239
ELISA, Flow, ICC/IF, IHC, IP, WB

Recombinant Monoclonal Antibody

ELISA
IHC, ELISA, Flow, IP

Recombinant Monoclonal Antibody

Catalog #: NBP2-14124PEP
AC
ELISA

Recombinant Monoclonal Antibody

ELISA
ELISA, ICC/IF

Recombinant monoclonal antibody expressed in HEK293F cells

ELISA
Flow, ICC
WB, Flow, IHC, CyTOF-ready
Results Per Page
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