GSK 1838705

Tocris Bioscience, part of Bio-Techne | Catalog # 5111

Potent IR and IGF1R inhibitor; also inhibits anaplastic lymphoma kinase (ALK)
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Key Product Details

Description

Potent IR and IGF1R inhibitor; also inhibits anaplastic lymphoma kinase (ALK)

View all Insulin and Insulin-like Receptor Inhibitors »

Product Description

GSK 1838705 is a potent insulin receptor (IR) and insulin-like growth factor-1 receptor (IGF1R) inhibitor (IC50 values are 1.6 and 2 nM, respectively). Also inhibits anaplastic lymphoma kinase (ALK) (IC50 = 0.5 nM). Displays > 800-fold selectivity for IR, IGFR1 and ALK over a panel of 44 kinases including JNK. Blocks proliferation of cancer cell lines in vitro, and causes complete regression of ALK-dependent tumors in vivo. Orally bioavailable.

Licensing Information

Sold for research purposes under agreement from GlaxoSmithKline.

Product Specifications

Molecular Weight

532.57

Formula

C27H29FN8O3

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

2-[[2-[[1-[(Dimethylamino)ethanoyl]-5-(methyloxy)-2,3-dihydro-1H-indol-6-yl]amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl]amino]-6-fluoro-N-methylbenzamide

CAS Number

1116235-97-2

PubChem ID

25182616

InChI Key

HZTYDQRUAWIZRE-UHFFFAOYSA-N

SMILES

O=C(CN(C)C)N4CCC(C4=C5)=CC(OC)=C5NC1=NC(NC3=C(C(NC)=O)C(F)=CC=C3)=C2C(NC=C2)=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 53.26 100

Preparing Stock Solutions for GSK 1838705

The following data is based on the product molecular weight 532.57

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.88 mL 9.39 mL 18.78 mL
5 mM 0.38 mL 1.88 mL 3.76 mL
10 mM 0.19 mL 0.94 mL 1.88 mL
50 mM 0.04 mL 0.19 mL 0.38 mL

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Background References

References are publications that support the biological activity of the product.

Product Documents for GSK 1838705

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for GSK 1838705

For research use only

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