IL-18 R alpha/IL-1 R5: Antibodies
Interleukin-18 (IL-18) is a member of the IL-1 family of cytokines and shares numerous immuno-regulatory functions with IL-12. The functional IL-18 receptor complex is composed of two subunits designated IL18 R alpha (also termed IL-1 R5 and IL-1 Rrp) and IL-18 R beta (also termed IL-1 R7 and AcPL). Both IL-18 R alpha and IL-18 R beta belong to the IL-1 receptor superfamily. Although IL-18 R by itself binds IL-18 with low affinity and IL-18 R beta does not bind IL18 in vitro, coexpression of IL-18 R alpha and IL18 R beta is required for high affinity binding and IL-18 responsiveness.
Human IL-18 R cDNA encodes a 541 amino acid (aa) precursor type I membrane protein with a hydrophobic signal, an extracellular domain comprised of three immunoglobulin-like domains, a transmembrane domain and a cytoplasmic region of approximately 200 aa residues. Human and mouse IL-18 R share 65% amino acid sequence homology. IL-18 R is widely expressed in numerous tissues including spleen, thymus, leukocyte, liver, lung, heart, small and large intestine, prostate and placenta.
26 results for "IL-18 R alpha/IL-1 R5 Primary Antibodies" in Products
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IL-18 R alpha/IL-1 R5: Antibodies
Interleukin-18 (IL-18) is a member of the IL-1 family of cytokines and shares numerous immuno-regulatory functions with IL-12. The functional IL-18 receptor complex is composed of two subunits designated IL18 R alpha (also termed IL-1 R5 and IL-1 Rrp) and IL-18 R beta (also termed IL-1 R7 and AcPL). Both IL-18 R alpha and IL-18 R beta belong to the IL-1 receptor superfamily. Although IL-18 R by itself binds IL-18 with low affinity and IL-18 R beta does not bind IL18 in vitro, coexpression of IL-18 R alpha and IL18 R beta is required for high affinity binding and IL-18 responsiveness.
Human IL-18 R cDNA encodes a 541 amino acid (aa) precursor type I membrane protein with a hydrophobic signal, an extracellular domain comprised of three immunoglobulin-like domains, a transmembrane domain and a cytoplasmic region of approximately 200 aa residues. Human and mouse IL-18 R share 65% amino acid sequence homology. IL-18 R is widely expressed in numerous tissues including spleen, thymus, leukocyte, liver, lung, heart, small and large intestine, prostate and placenta.
26 results for "IL-18 R alpha/IL-1 R5 Primary Antibodies" in Products
Clonality : | Polyclonal |
Host : | Goat IgG |
Applications : | Block/Neutralize, CyTOF-ready, Flow Cytometry, Immunohistochemistry, Western Blot |
Clonality : | Monoclonal |
Host : | Mouse IgG1 Clone #70625 |
Applications : | Block/Neutralize, CyTOF-ready, Flow Cytometry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry |
Clonality : | Monoclonal |
Host : | Rat IgG1 Clone #112614 |
Applications : | CyTOF-ready, Flow Cytometry, Western Blot |
Clonality : | Polyclonal |
Host : | Goat IgG |
Applications : | Flow Cytometry, Western Blot |
Clonality : | Monoclonal |
Host : | Rat IgG2a Clone #112624 |
Applications : | Block/Neutralize, Western Blot |
Clonality : | Polyclonal |
Host : | Goat IgG |
Applications : | Block/Neutralize, CyTOF-ready, Flow Cytometry, Western Blot |
Clonality : | Monoclonal |
Host : | Mouse IgG1 Clone #70625 |
Applications : | Flow Cytometry |
Clonality : | Monoclonal |
Host : | Rat IgG1 Clone #112614 |
Applications : | Flow Cytometry |
Clonality : | Monoclonal |
Host : | Mouse IgG1 Clone #70625 |
Applications : | Flow Cytometry |
Clonality : | Monoclonal |
Host : | Rat IgG1 Clone #112614 |
Applications : | Flow Cytometry |
Clonality : | Monoclonal |
Host : | Mouse IgG1 Clone #70625 |
Applications : | Flow Cytometry |
Clonality : | Monoclonal |
Host : | Mouse IgG1 Clone #70625 |
Applications : | Flow Cytometry |
Clonality : | Monoclonal |
Host : | Rat IgG1 Clone #112614 |
Applications : | Flow Cytometry |
Clonality : | Monoclonal |
Host : | Mouse IgG1 Clone #70625 |
Applications : | Flow Cytometry |
Clonality : | Monoclonal |
Host : | Mouse IgG1 Clone #70625 |
Applications : | Flow Cytometry |
Clonality : | Monoclonal |
Host : | Mouse IgG1 Clone #70625 |
Applications : | Flow Cytometry |
Clonality : | Monoclonal |
Host : | Mouse IgG1 Clone #70614 |
Applications : | Western Blot |
Clonality : | Polyclonal |
Host : | Goat IgG |
Applications : | Western Blot |
Clonality : | Monoclonal |
Host : | Rat IgG1 Clone #112614 |
Applications : | Flow Cytometry |
Clonality : | Monoclonal |
Host : | Rat IgG1 Clone #112614 |
Applications : | Flow Cytometry |
Clonality : | Monoclonal |
Host : | Rat IgG1 Clone #112614 |
Applications : | Flow Cytometry |
Clonality : | Monoclonal |
Host : | Mouse IgG1 Clone #70625 |
Applications : | Flow Cytometry |
Clonality : | Monoclonal |
Host : | Rat IgG1 Clone #112614 |
Applications : | Flow Cytometry |
Clonality : | Monoclonal |
Host : | Mouse IgG1 Clone #70625 |
Applications : | Flow Cytometry |
Clonality : | Monoclonal |
Host : | Rat IgG1 Clone #112614 |
Applications : | Flow Cytometry |