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8 results for "Group II mGluR Agonists" in Products

Group II mGluR Agonists Products

Metabotropic Glutamate (mGlu) group II receptors are members of the metabotropic class of glutamate receptors, which also includes mGlu group I and mGlu group III receptors. Group II receptors are divided into two subtypes, mGlu2 and mGlu3. mGlu group II receptors are coupled to Gi/o, which inhibits adenylyl cyclase, decreasing the formation of cAMP. These receptors are involved in presynaptic inhibition and do not appear to affect postsynaptic membrane potential by themselves. The human genes for mGlu2 and mGlu3 receptors have been localized to chromosomes 3 (p21.1) and 7 (7q21.1-q21.2) respectively.

Highly potent group II mGlu agonist; also NMDA agonist

Chemical Name: (2S,2'R,3'R)-2-(2',3'-Dicarboxycyclopropyl)glycine
Purity: ≥98% (HPLC)
Highly potent group II mGlu agonist; also NMDA agonist

Highly selective group II mGlu agonist

Chemical Name: (1R,4R,5S,6R)-4-Amino-2-oxabicyclo[3.1.0]hexane-4,6-dicarboxylic acid
Purity: ≥99% (HPLC)
Highly selective group II mGlu agonist

Potent and highly selective group II mGlu agonist

Chemical Name: (1S,2S,5R,6S)-2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid
Purity: ≥98% (HPLC)
Potent and highly selective group II mGlu agonist

Competitive group I mGlu antagonist; also weak group II agonist

Alternate Names: (S)-4CPG
Purity: ≥98% (HPLC)
Competitive group I mGlu antagonist; also weak group II agonist

Potent group II mGlu agonist

Alternate Names: (2S,3S,4S)-CCG
Chemical Name: (2S,1'S,2'S)-2-(Carboxycyclopropyl)glycine
Purity: ≥99% (HPLC)
Potent group II mGlu agonist

Selective group II mGlu agonist; sodium salt of LY 379268 (Cat. No. 2453)

Chemical Name: (1R,4R,5S,6R)-4-Amino-2-oxabicyclo[3.1.0]hexane-4,6-dicarboxylic acid disodium salt
Purity: ≥98% (HPLC)
Selective group II mGlu agonist; sodium salt of LY 379268 (Cat. No. 2453)

Highly selective group II agonist

Chemical Name: (2R,4R)-4-Aminopyrrolidine-2,4-dicarboxylate
Purity: ≥98% (HPLC)
Highly selective group II agonist

Group I and II mGlu agonist

Chemical Name: (±)-1-Aminocyclopentane-trans-1,3-dicarboxylic acid
Purity: ≥99% (HPLC)
Group I and II mGlu agonist
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