L-CCG-l

Name: L-CCG-l
Brand: Tocris Bioscience
SKU: 0333

Tocris Bioscience a Bio-Techne Brand

Catalog # 0333

Citations (4)

COA / SDS

Catalog #

Availability

Size / Price

Qty

Key Product Details

Description:	Potent group II mGlu agonist
Alternative Names:	(2S,3S,4S)-CCG
Chemical Name:	(2S,1'S,2'S)-2-(Carboxycyclopropyl)glycine
Purity:	≥99% (HPLC)
Molecular Weight:	159.14

View Full Technical Details for L-CCG-l

Biological Activity for L-CCG-l

L-CCG-l is a potent group II metabotropic glutamate receptor agonist. More active than glutamate or (±)-trans-ACPD (Cat. No. 0187).

Technical Data for L-CCG-l

M. Wt	159.14
Formula	C₆H₉NO₄
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	117857-93-9
PubChem ID	5310956
InChi Key	GZOVEPYOCJWRFC-HZLVTQRSSA-N
Smiles	N[C@]([H])(C(O)=O)[C@@]([H])(C1)[C@]1([C@@](O)=O)[H]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for L-CCG-l

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	1eq. NaOH		100

Preparing Stock Solutions for L-CCG-l

The following data is based on the product molecular weight 159.14.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	6.28 mL	31.42 mL	62.84 mL
5 mM	1.26 mL	6.28 mL	12.57 mL
10 mM	0.63 mL	3.14 mL	6.28 mL
50 mM	0.13 mL	0.63 mL	1.26 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for L-CCG-l

References are publications that support the biological activity of the product.

Brabet Comparative effect of L-CCG-I, DCG-IV and γ-carboxy-L-glutamate on all cloned metabotropic glutamate receptor subtypes. Neuropharmacology 1998 PMID: 9833633
Wright and Schoepp Differentiation of group 2 and group 3 metabotropic glutamate receptor cAMP responses in the rat hippocampus. Eur.J.Pharmacol. 1996 PMID: 8666060
Hayashi Agonist analysis of 2-(carboxycyclopropyl)glycine isomers for cloned metabotropic glutamate receptor subtypes expressed in Chinese hamster ovary cells. Br.J.Pharmacol. 1992 PMID: 1330184
Shinozaki Potent NMDA-like actions and potentiation of glutamate responses by conformational variants of a glutamate analogue in the rat spinal cord. Br.J.Pharmacol. 1989 PMID: 2692753

Citations for L-CCG-l (4)

Showing 1 - 4 of 4 citations Showing All

Search Title:

Citations are publications that use Bio-Techne products. Selected citations for L-CCG-l include:

Scholler (2017) HTS-compatible FRET-based conformational sensors clarify membrane receptor activation. Nat Chem Biol. 13(4):372
PMID: 28135236
Han et al. (2015) Alleviation of kainic acid-induced brain barrier dysfunction by 4-o-methylhonokiol in in vitro and in vivo models. Biomed Res Int. 2015:893163
PMID: 25688368
Caiati et al. (2012) Developmental regulation of CB1-mediated spike-time dependent depression at immature mossy fiber-CA3 synapses. Sci Rep. 2:285
PMID: 22368777
Ster et al. (2011) Enhancement of CA3 hippocampal network activity by activation of group II metabotropic glutamate receptors. Neuron. 108:9993
PMID: 21628565

There are no citations that match your criteria.