8 results for "Group II mGluR Agonists" in Products
Group II mGluR Agonists Products
Metabotropic Glutamate (mGlu) group II receptors are members of the metabotropic class of glutamate receptors, which also includes mGlu group I and mGlu group III receptors. Group II receptors are divided into two subtypes, mGlu2 and mGlu3. mGlu group II receptors are coupled to Gi/o, which inhibits adenylyl cyclase, decreasing the formation of cAMP. These receptors are involved in presynaptic inhibition and do not appear to affect postsynaptic membrane potential by themselves. The human genes for mGlu2 and mGlu3 receptors have been localized to chromosomes 3 (p21.1) and 7 (7q21.1-q21.2) respectively.
Highly potent group II mGlu agonist; also NMDA agonist
| Chemical Name: | (2S,2'R,3'R)-2-(2',3'-Dicarboxycyclopropyl)glycine |
| Purity: | ≥98% (HPLC) |
Highly selective group II mGlu agonist
| Chemical Name: | (1R,4R,5S,6R)-4-Amino-2-oxabicyclo[3.1.0]hexane-4,6-dicarboxylic acid |
| Purity: | ≥99% (HPLC) |
Potent and highly selective group II mGlu agonist
| Chemical Name: | (1S,2S,5R,6S)-2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid |
| Purity: | ≥98% (HPLC) |
Competitive group I mGlu antagonist; also weak group II agonist
| Alternate Names: | (S)-4CPG |
| Purity: | ≥98% (HPLC) |
Potent group II mGlu agonist
| Alternate Names: | (2S,3S,4S)-CCG |
| Chemical Name: | (2S,1'S,2'S)-2-(Carboxycyclopropyl)glycine |
| Purity: | ≥99% (HPLC) |
Selective group II mGlu agonist; sodium salt of LY 379268 (Cat. No. 2453)
| Chemical Name: | (1R,4R,5S,6R)-4-Amino-2-oxabicyclo[3.1.0]hexane-4,6-dicarboxylic acid disodium salt |
| Purity: | ≥98% (HPLC) |
Highly selective group II agonist
| Chemical Name: | (2R,4R)-4-Aminopyrrolidine-2,4-dicarboxylate |
| Purity: | ≥98% (HPLC) |
Group I and II mGlu agonist
| Chemical Name: | (±)-1-Aminocyclopentane-trans-1,3-dicarboxylic acid |
| Purity: | ≥99% (HPLC) |
