DCG IV

Name: DCG IV
Brand: Tocris Bioscience
SKU: 0975

Tocris Bioscience, part of Bio-Techne | Catalog # 0975

Citations (191)

COA / SDS

Highly potent group II mGlu agonist; also NMDA agonist

Key Product Details

Description:	Highly potent group II mGlu agonist; also NMDA agonist
Chemical Name:	(2S,2'R,3'R)-2-(2',3'-Dicarboxycyclopropyl)glycine
Purity:	≥98% (HPLC)
Molecular Weight:	203.15

View Full Technical Details for DCG IV

Technical Data
Citations

Biological Activity for DCG IV

DCG IV is a presynaptic depressant; highly potent agonist for group II mGlu receptors.

Licensing Information

Sold with the permission of Suntory Ltd.

Technical Data for DCG IV

M. Wt	203.15
Formula	C₇H₉NO₆
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	147782-19-2
PubChem ID	16758827
InChi Key	MATPZHBYOVDBLI-FKNRSBSYSA-N
Smiles	N[C@]([H])(C(O)=O)[C@]1(C([H])(C(O)=O)C([H])1C(O)=O)[H]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for DCG IV

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	20.32	100

Preparing Stock Solutions for DCG IV

The following data is based on the product molecular weight 203.15.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.92 mL	24.61 mL	49.22 mL
5 mM	0.98 mL	4.92 mL	9.84 mL
10 mM	0.49 mL	2.46 mL	4.92 mL
50 mM	0.10 mL	0.49 mL	0.98 mL

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Reconstitution Calculator

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References for DCG IV

References are publications that support the biological activity of the product.

Ohfune Synthesis of L-2-(2,3-dicarboxycyclopropyl)-glycines. Novel conformationally restricted glutamate analogues. Bioorg.Med.Chem.Lett.
Cartmell Characterization of [³H]-(2S,2'R,3'R)-2-(2',3'-dicarboxycyclopropyl)glycine ([³H]-DCG IV) binding to metabotropic mGlu₂ receptor-transfected cell membranes. Br.J.Pharmacol. 1998 PMID: 9504391
Ishida A novel metabotropic receptor agonist: marked depression of monosynaptic excitation in the isolated rat spinal cord. Br.J.Pharmacol. 1993 PMID: 8401927
Brabet Comparative effect of L-CCG-I, DCG-IV and γ-carboxy-L-glutamate on all cloned metabotropic glutamate receptor subtypes. Neuropharmacology 1998 PMID: 9833633