DCG IV
Tocris Bioscience, part of Bio-Techne | Catalog # 0975
Highly potent group II mGlu agonist; also NMDA agonist
Key Product Details
Description
Highly potent group II mGlu agonist; also NMDA agonist
Product Description
DCG IV is a presynaptic depressant; highly potent agonist for group II mGlu receptors.Licensing Information
Sold with the permission of Suntory Ltd.Product Specifications
Molecular Weight
203.15
Formula
C7H9NO6
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
(2S,2'R,3'R)-2-(2',3'-Dicarboxycyclopropyl)glycine
CAS Number
147782-19-2
PubChem ID
16758827
InChI Key
MATPZHBYOVDBLI-FKNRSBSYSA-N
SMILES
N[C@]([H])(C(O)=O)[C@]1(C([H])(C(O)=O)C([H])1C(O)=O)[H]
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 20.32 | 100 |
Preparing Stock Solutions
for DCG IV
The following data is based on the product molecular weight 203.15
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.92 mL | 24.61 mL | 49.22 mL |
| 5 mM | 0.98 mL | 4.92 mL | 9.84 mL |
| 10 mM | 0.49 mL | 2.46 mL | 4.92 mL |
| 50 mM | 0.10 mL | 0.49 mL | 0.98 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Ohfune Synthesis of L-2-(2,3-dicarboxycyclopropyl)-glycines. Novel conformationally restricted glutamate analogues. Bioorg.Med.Chem.Lett.
- Cartmell Characterization of [3H]-(2S,2'R,3'R)-2-(2',3'-dicarboxycyclopropyl)glycine ([3H]-DCG IV) binding to metabotropic mGlu2 receptor-transfected cell membranes. Br.J.Pharmacol. 1998 PMID: 9504391
- Ishida A novel metabotropic receptor agonist: marked depression of monosynaptic excitation in the isolated rat spinal cord. Br.J.Pharmacol. 1993 PMID: 8401927
- Brabet Comparative effect of L-CCG-I, DCG-IV and γ-carboxy-L-glutamate on all cloned metabotropic glutamate receptor subtypes. Neuropharmacology 1998 PMID: 9833633
Product Specific Notices for DCG IV
For research use only
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