Key Product Details
Description: | Highly potent group II mGlu agonist; also NMDA agonist |
Chemical Name: | (2S,2'R,3'R)-2-(2',3'-Dicarboxycyclopropyl)glycine |
Purity: | ≥98% (HPLC) |
Molecular Weight: | 203.15 |
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Citations for DCG IV (33)
Citations are publications that use Bio-Techne products. Selected citations for DCG IV include:
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Scholler
(2017)
HTS-compatible FRET-based conformational sensors clarify membrane receptor activation.
Nat Chem Biol.
13(4):372
PMID: 28135236 -
Scholler
(2017)
Allosteric nanobodies uncover a role of hippocampal mGlu2 receptor homodimers in contextual fear consolidation.
Nat Commun.
8(1):1967
PMID: 29213077 -
Hashimotodani et al.
(2017)
LTP at Hilar Mossy Cell-Dentate Granule Cell Synapses Modulates Dentate Gyrus Output by Increasing Excitation/Inhibition Balance.
Neuron.
95:928
PMID: 28817805 -
Sun et al.
(2017)
Proximodistal Heterogeneity of Hippocampal CA3 Pyramidal Neuron Intrinsic Properties, Connectivity, and Reactivation during Memory Recall.
Neuron.
95:656
PMID: 28772124 -
Miguel Angel Garcia-Bereguiain et al.
(2016)
Spontaneous Release Regulates Synaptic Scaling in the Embryonic Spinal Network In Vivo
The Journal of Neuroscience.
6:7268
PMID: 27383600 -
Martin et al.
(2015)
The intellectual disability gene Kirrel3 regulates target-specific mossy fiber synapse development in the hippocampus.
Elife.
4
PMID: 26575286 -
Suberbielle et al.
(2015)
DNA repair factor BRCA1 depletion occurs in Alzheimer brains and impairs cognitive function in mice.
Acta Neuropathol Commun.
6:8897
PMID: 26615780 -
Decker et al.
(2015)
Pro-aggregant Tau impairs mossy fiber plasticity due to structural changes and Ca(++) dysregulation.
Cell Rep.
3:23
PMID: 25853683 -
Ben-Simon et al.
(2015)
A Combined Optogenetic-Knockdown Strategy Reveals a Major Role of Tomosyn in Mossy Fiber Synaptic Plasticity.
J Neurosci.
12:396
PMID: 26166572 -
Galván et al.
(2015)
Synapse-specific compartmentalization of signaling cascades for LTP induction in CA3 interneurons.
Neuroscience.
290:332
PMID: 25637803 -
Maurin et al.
(2014)
Early structural and functional defects in synapses and myelinated axons in stratum lacunosum moleculare in two preclinical models for tauopathy.
PLoS One.
9:e87605
PMID: 24498342 -
Yin et al.
(2014)
Selective actions of novel allosteric modulators reveal functional heteromers of metabotropic glutamate receptors in the CNS.
J Neurosci.
34:79
PMID: 24381270 -
Kaeser-Woo et al.
(2013)
Synaptotagmin-12 phosphorylation by cAMP-dependent protein kinase is essential for hippocampal mossy fiber LTP.
J Neurosci.
33:9769
PMID: 23739973 -
Skucas et al.
(2013)
Testosterone depletion in adult male rats increases mossy fiber transmission, LTP, and sprouting in area CA3 of hippocampus.
J Neurosci.
33:2338
PMID: 23392664 -
Caiati et al.
(2012)
Developmental regulation of CB1-mediated spike-time dependent depression at immature mossy fiber-CA3 synapses.
Sci Rep.
2:285
PMID: 22368777 -
Vivar et al.
(2012)
Mixed electrical-chemical transmission between hippocampal mossy fibers and pyramidal cells.
Eur J Neurosci.
35:76
PMID: 22151275 -
Sydow et al.
(2011)
Tau-induced defects in synaptic plasticity, learning, and memory are reversible in transgenic mice after switching off the toxic Tau mutant.
J Neurosci.
31:2511
PMID: 21325519 -
Prickett et al.
(2011)
Exon capture analysis of G protein-coupled receptors identifies activating mutations in GRM3 in melanoma.
Nat Genet.
43:1119
PMID: 21946352 -
Taman and Ribeiro
(2011)
Characterization of a truncated metabotropic glutamate receptor in a primitive metazoan, the parasitic flatworm Schistosoma mansoni.
PLoS One.
6:e27119
PMID: 22069494 -
Straub et al.
(2011)
Distinct functions of kainate receptors in the brain are determined by the auxiliary subunit Neto1.
Nat Neurosci.
14:866
PMID: 21623363 -
Ster et al.
(2011)
Enhancement of CA3 hippocampal network activity by activation of group II metabotropic glutamate receptors.
Proc Natl Acad Sci U S A.
108:9993
PMID: 21628565 -
Torborg et al.
(2010)
Control of CA3 output by feedforward inhibition despite developmental changes in the excitation-inhibition balance.
J Neurosci.
30:15628
PMID: 21084618 -
Hagena and Manahan-Vaughan
(2010)
Frequency facilitation at mossy fiber-CA3 synapses of freely behaving rats contributes to the induction of persistent LTD via an adenosine-A1 receptor-regulated mechanism.
Cereb Cortex.
20:1121
PMID: 19903765 -
Galván et al.
(2010)
Critical involvement of postsynaptic protein kinase activation in long-term potentiation at hippocampal mossy fiber synapses on CA3 interneurons.
J Neurosci.
30:2844
PMID: 20181582 -
Kim et al.
(2010)
Group II metabotropic glutamate receptor stimulation triggers production and release of Alzheimer's amyloid(β)42 from isolated intact nerve terminals.
Nat Commun.
30:3870
PMID: 20237257 -
Lee and Sherman
(2009)
Glutamatergic inhibition in sensory neocortex.
Cereb Cortex.
19:2281
PMID: 19176638 -
Bagayogo and Dreyfus
(2009)
Regulated release of BDNF by cortical oligodendrocytes is mediated through metabotropic glutamate receptors and the PLC pathway.
ASN Neuro.
1
PMID: 19570026 -
Kim and Tsien
(2008)
Synapse-specific adaptations to inactivity in hippocampal circuits achieve homeostatic gain control while dampening network reverberation.
Neuron.
58:925
PMID: 18579082 -
Suh et al.
(2008)
Corequirement of PICK1 binding and PKC phosphorylation for stable surface expression of the metabotropic glutamate receptor mGluR7.
Neuron.
58:736
PMID: 18549785 -
Wang et al.
(2008)
BACE1 knock-outs display deficits in activity-dependent potentiation of synaptic transmission at mossy fiber to CA3 synapses in the hippocampus.
Proc Natl Acad Sci U S A.
28:8677
PMID: 18753368 -
Chiu and Castillo
(2008)
Input-specific plasticity at excitatory synapses mediated by endocannabinoids in the dentate gyrus.
Neuropharmacology.
54:68
PMID: 17706254 -
Andrieux et al.
(2002)
The suppression of brain cold-stable microtubules in mice induces synaptic defects associated with neuroleptic-sensitive behavioral disorders.
Genes Dev.
16:2350
PMID: 12231625 -
Yeckel et al.
(1999)
Multiple forms of LTP in hippocampal CA3 neurons use a common postsynaptic mechanism.
Nat Neurosci.
2:625
PMID: 10404192
There are no citations that match your criteria.