(S)-4-Carboxyphenylglycine

Name: ( S )-4-Carboxyphenylglycine
Brand: Tocris Bioscience
SKU: 0323
Rating: 4 (1 reviews)

Tocris Bioscience a Bio-Techne Brand

Catalog # 0323

Citations (7)

(1)

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Key Product Details

Description:	Competitive group I mGlu antagonist; also weak group II agonist
Alternative Names:	(S)-4CPG
Purity:	≥99% (HPLC)
Molecular Weight:	195.17

View Full Technical Details for (S)-4-Carboxyphenylglycine

Biological Activity for (S)-4-Carboxyphenylglycine

(S)-4-Carboxyphenylglycine is a competitive group I metabotropic glutamate receptor antagonist, with selectivity for mGlu_1a/1a over mGlu_5a/5b.

Technical Data for (S)-4-Carboxyphenylglycine

M. Wt	195.17
Formula	C₉H₉NO₄
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	134052-73-6
PubChem ID	5311459
InChi Key	VTMJKPGFERYGJF-ZETCQYMHSA-N
Smiles	[H][C@@](N)(C(O)=O)C1=CC=C(C(O)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for (S)-4-Carboxyphenylglycine

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	1eq. NaOH	19.52	100 with gentle warming

Preparing Stock Solutions for (S)-4-Carboxyphenylglycine

The following data is based on the product molecular weight 195.17.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	5.12 mL	25.62 mL	51.24 mL
5 mM	1.02 mL	5.12 mL	10.25 mL
10 mM	0.51 mL	2.56 mL	5.12 mL
50 mM	0.10 mL	0.51 mL	1.02 mL

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References for (S)-4-Carboxyphenylglycine

References are publications that support the biological activity of the product.

Doherty Antagonist activity of α-substituted 4-carboxyphenylglycine analogues at group I metabotropic glutamate receptors expressed in CHO cells. Br.J.Pharmacol. 1999 PMID: 10051137
Brabet Phenylglycine derivatives discriminate between mGluR1-and mGluR5-mediated responses. Neuropharmacology 1995 PMID: 8532171
Birse Phenylglycine derivatives as new pharmacological tools for investigating the role of metabotropic glutamate receptors in the central nervous system. Neuroscience 1993 PMID: 7680790
Eaton Competitive antagonism at metabotropic glutamate receptors by (S)-4-carboxyphenylglycine (CPG) and (RS)-α-methyl-4-carboxyphenylglycine (MCPG). Eur.J.Pharmacol. 1993 PMID: 8381746

Citations for (S)-4-Carboxyphenylglycine (7)

Showing 1 - 7 of 7 citations Showing All

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Citations are publications that use Bio-Techne products. Selected citations for (S)-4-Carboxyphenylglycine include:

Riz et al. (2016) Noncanonical SQSTM1/p62-Nrf2 pathway activation mediates proteasome inhibitor resistance in multiple myeloma cells via redox, metabolic and translational reprogramming. Oncotarget. 7:66360
PMID: 27626179
Griffin et al. (2015) Repeated cycles of chronic intermittent ethanol exposure increases basal glutamate in the nucleus accumbens of mice without affecting glutamate transport. Front Pharmacol. 6:27
PMID: 25755641
Resch et al. (2014) Augmented cystine-glutamate exchange by pituitary adenylate cyclase-activating polypeptide signaling via the VPAC1 receptor. Synapse. 2014;
PMID: 25066643
Mahler et al. (2014) Modafinil attenuates reinstatement of cocaine seeking: role for cystine-glutamate exchange and metabotropic glutamate receptors. J Young Investig. 19:49
PMID: 23017017
Overocker and Pfau (2012) Cytokine Production Modified by System X(c)- After PM10 and Asbestos Exposure. Proc Natl Acad Sci U S A. 23:34
PMID: 23418405
Liu et al. (2007) Cystine-glutamate transporter SLC7A11 mediates resistance to geldanamycin but not to 17-(allylamino)-17-demethoxygeldanamycin. Mol Pharmacol. 72:1637
PMID: 17875604
Porter et al. (2005) Fenobam: a clinically validated nonbenzodiazepine anxiolytic is a potent, selective, and noncompetitive mGlu5 receptor antagonist with inverse agonist activity. J Pharmacol Exp Ther. 315:711
PMID: 16040814

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Showing 1 - 7 of 7 citations Showing All

Customer Reviews for (S)-4-Carboxyphenylglycine (1)

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(S)-4-carboxyphenylglycine (CPG)(0.2 uM)

Name: Anonymous

Species: Human

Assay Type: In Vitro

Cell Line/Tissue: LP-1 cell line

Treatment with (S)-4-carboxyphenylglycine (CPG) ensitizes LP-1/Cfz cells. Cellswere treated with the indicated concentrations of carfilzomib for 72 hours in the absence or presence of CPG (0.2 uM)

PMID: 27626179

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