LY 379268 disodium salt

Name: LY 379268 disodium salt
Brand: Tocris Bioscience
SKU: 5064

Tocris Bioscience a Bio-Techne Brand

Catalog # 5064

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Key Product Details

Description:	Selective group II mGlu agonist; sodium salt of LY 379268 (Cat. No. 2453)
Chemical Name:	(1R,4R,5S,6R)-4-Amino-2-oxabicyclo[3.1.0]hexane-4,6-dicarboxylic acid disodium salt
Purity:	≥98% (HPLC)
Molecular Weight:	231.11

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Biological Activity for LY 379268 disodium salt

LY 379268 disodium salt is a sodium salt of LY 379268 (Cat. No. 2453), a highly selective group II mGlu receptor agonist.

Technical Data for LY 379268 disodium salt

M. Wt	231.11
Formula	C₇H₇NNa₂O₅
Storage	Desiccate at RT
Purity	≥98% (HPLC)
PubChem ID	10197984
InChi Key	YASVRZWVUGJELU-MDASVERJSA-N
Smiles	[H][C@]12[C@]([C@H]2[C@](O[Na])=O)([H])[C@@]([C@](O[Na])=O)(N)CO1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for LY 379268 disodium salt

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	23.11	100

Preparing Stock Solutions for LY 379268 disodium salt

The following data is based on the product molecular weight 231.11.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.33 mL	21.63 mL	43.27 mL
5 mM	0.87 mL	4.33 mL	8.65 mL
10 mM	0.43 mL	2.16 mL	4.33 mL
50 mM	0.09 mL	0.43 mL	0.87 mL

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References for LY 379268 disodium salt

References are publications that support the biological activity of the product.

Collado (2S,1'S,2'S,3'R)-2-(2'-carboxy-3'-methylcyclopropyl) glycine is a potent and selective metabotropic group 2 agonist with anxiolytic properties. J.Med.Chem. 2002 PMID: 12166935
Bond Neuroprotective effects of LY379268, a selective mGlu2/3 receptor agonist: investigations into possible mechanisms of action in vivo. J.Pharmacol.Exp.Ther. 2000 PMID: 10945827
Bond LY379268, a potent and selective group II metabotropic glutamate receptor agonist, is neuroprotective in gerbil global, but not focal cerebral ischaemia. Neurosci.Lett. 1999 PMID: 10515191

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