(2R,4R)-APDC
Tocris Bioscience, part of Bio-Techne | Catalog # 1208
Highly selective group II agonist
Key Product Details
Description
Highly selective group II agonist
Product Description
(2R,4R)-APDC is a highly selective and relatively potent group II metabotropic glutamate receptor agonist. EC50 values are 0.4, 0.4, > 100, > 100, > 300 and > 300 μM for human mGlu2, mGlu3, mGlu1, mGlu5, mGlu4 and mGlu7 receptors respectively. Centrally active following systemic administration in vivo.Licensing Information
Sold with the permission of Eli Lilly and CompanyProduct Specifications
Molecular Weight
174.16
Formula
C6H10N2O4
Storage
Desiccate at RT
Purity
≥98% (HPLC)
Chemical Name
(2R,4R)-4-Aminopyrrolidine-2,4-dicarboxylate
CAS Number
169209-63-6
PubChem ID
5310984
InChI Key
XZFMJVJDSYRWDQ-AWFVSMACSA-N
SMILES
N[C@]1([C@](O)=O)C[C@H]([C@](O)=O)NC1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 100 |
Preparing Stock Solutions
for (2R,4R)-APDC
The following data is based on the product molecular weight 174.16
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 5.74 mL | 28.71 mL | 57.42 mL |
| 5 mM | 1.15 mL | 5.74 mL | 11.48 mL |
| 10 mM | 0.57 mL | 2.87 mL | 5.74 mL |
| 50 mM | 0.11 mL | 0.57 mL | 1.15 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Schoepp Selective inhibition of forskolin-stimulated cyclic AMP formation in rat hippocampus by a novel mGluR agonist, 2R,4R-4-aminopyrrolidine-2,4-dicarboxylate. Neuropharmacology 1995 PMID: 8532165
- Schoepp Pharmacological agents acting at subtypes of metabotropic glutamate receptors. Neuropharmacology 1999 PMID: 10530808
- Monn Synthesis of the four isomers of 4-aminopyrrolidine-2,4-dicarboxylate: identification of a potent, highly selective, and systemically active agonist for metabotropic glutamate receptors negatively coupled to adenylate cyclase. J.Med.Chem. 1996 PMID: 8709133
Product Specific Notices for (2R,4R)-APDC
For research use only
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