GPR55: Small Molecules and Peptides
Members of the G protein-coupled receptor (GPCR) family, such as GPR55, play important roles in signal transduction from the external environment to the inside of the cell. GPR55 is a receptor for L-alpha-lysophosphatidylinositol (LPI). LPI induces Ca2+ release from intracellular stores via the heterotrimeric G protein GNA13 and RHOA. GPR55 is expressed in the caudate nucleus and putamen, but not detected in the hippocampus, thalamus, pons cerebellum, frontal cortex of the brain or in the liver. It is expressed in osteoclasts and osteoblasts. GPR55 may play a role in bone physiology by regulating osteoclast number and function. GPR55 may also be involved in hyperalgesia associated with inflammatory and neuropathic pain.
10 results for "GPR55 Small Molecules and Peptides" in Products
10 results for "GPR55 Small Molecules and Peptides" in Products
GPR55: Small Molecules and Peptides
Members of the G protein-coupled receptor (GPCR) family, such as GPR55, play important roles in signal transduction from the external environment to the inside of the cell. GPR55 is a receptor for L-alpha-lysophosphatidylinositol (LPI). LPI induces Ca2+ release from intracellular stores via the heterotrimeric G protein GNA13 and RHOA. GPR55 is expressed in the caudate nucleus and putamen, but not detected in the hippocampus, thalamus, pons cerebellum, frontal cortex of the brain or in the liver. It is expressed in osteoclasts and osteoblasts. GPR55 may play a role in bone physiology by regulating osteoclast number and function. GPR55 may also be involved in hyperalgesia associated with inflammatory and neuropathic pain.
Endogenous and non-selective CB agonist; potent GPR55 agonist
| Alternate Names: | 2-AG,Arachidonoylglycerol |
| Chemical Name: | (5Z,8Z,11Z,14Z)-5,8,11,14-Eicosatetraenoic acid, 2-hydroxy-1-(hydroxymethyl)ethyl ester |
Lipid mediator, anorexic actions; also GPR55 and PPARα agonist
| Chemical Name: | (9Z)-N-(2-Hydroxyethyl)-9-octadecenamide |
| Purity: | ≥99% (HPLC) |
Potent CB1 antagonist; also GPR55 agonist
| Chemical Name: | N-(Piperidin-1-yl)-5-(4-iodophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide |
| Purity: | ≥98% (HPLC) |
Natural cannabinoid; GPR55 antagonist, weak CB1 antagonist, CB2 inverse agonist and AMT inhibitor
| Alternate Names: | CBD |
| Chemical Name: | 2-[(1R,6R)-3-Methyl-6-(1-methylethenyl)-2-cyclohexen-1-yl]-5-pentyl-1,3-benzenediol |
| Purity: | ≥98% (HPLC) |
Endogenous and non-selective CB agonist
| Alternate Names: | Arachidonylethanolamide,AEA |
| Chemical Name: | N-(2-Hydroxyethyl)-5Z,8Z,11Z,14Z-eicosatetraenamide |
| Purity: | ≥98% (HPLC) |
Selective GPR55 agonist. FAAH and PAA substrate
| Alternate Names: | PEA |
| Chemical Name: | N-(2-Hydroxyethyl)hexadecanamide |
Potent GPR55 agonist
| Chemical Name: | 5-Methyl-4-[(1R,6R)-3-methyl-6-(1-methylethenyl)-2-cyclohexen-1-yl]-1,3-benzenediol |
| Purity: | ≥97% (HPLC) |
Potent, selective GPR55 antagonist
| Alternate Names: | CID 1261822 |
| Chemical Name: | N-[4-[[(3,4-Dimethyl-5-isoxazolyl)amino]sulfonyl]phenyl]-6,8-dimethyl-2-(2-pyridinyl)-4-quinolinecarboxamide |
| Purity: | ≥98% (HPLC) |
Selective GPR55 antagonist
| Chemical Name: | 4-[4,6-Dihydro-4-(3-hydroxyphenyl)-3-(4-methylphenyl)-6-oxopyrrolo[3,4-c]pyrazol-5(1H)-yl]benzoic acid |
| Purity: | ≥98% (HPLC) |
Selective GPR55 agonist; also promotes NSC proliferation and differentiation
| Alternate Names: | CID 20440433 |
| Chemical Name: | 3-[[4-(2,3-Dimethylphenyl)-1-piperazinyl]carbonyl]-N,N-dimethyl-4-(1-pyrrolidinyl)benzenesulfonamide |
| Purity: | ≥98% (HPLC) |
