Key Product Details
Description: | Potent CB1 antagonist; also GPR55 agonist |
Chemical Name: | N-(Piperidin-1-yl)-5-(4-iodophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide |
Purity: | ≥99% (HPLC) |
Molecular Weight: | 555.24 |
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Citations for AM 251 (200)
Citations are publications that use Bio-Techne products. Selected citations for AM 251 include:
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Ellermann et al.
(2020)
Endocannabinoids inhibit the induction of virulence in enteric pathogens.
Cell.
2020;
PMID: 33031742 -
Diniz et al.
(2019)
Dual mechanism of TRKB activation by anandamide through CB1 and TRPV1 receptors.
PeerJ.
7:e6493
PMID: 30809460 -
Miranda et al.
(2019)
Cannabinoid Receptor 1 Blockade Attenuates Obesity and Adipose Tissue Type 1 Inflammation Through miR-30e-5p Regulation of Delta-Like-4 in Macrophages and Consequently Downregulation of Th1 Cells.
Front Immunol.
10:1049
PMID: 31134094 -
Hu et al.
(2019)
Endocannabinoid Signaling Mediates Local Dendritic Coordination between Excitatory and Inhibitory Synapses.
Cell Rep.
27:666
PMID: 30995465 -
Nasrallah et al.
(2019)
Routing Hippocampal Information Flow through Parvalbumin Interneuron Plasticity in Area CA2.
Cell Rep.
27:86
PMID: 30943417 -
Alharris et al.
(2019)
Role of miRNA in the regulation of cannabidiol-mediated apoptosis in neuroblastoma cells.
Oncotarget.
10:45
PMID: 30713602 -
Xiao et al.
(2018)
OXT functions as a spatiotemporal filter for excitatory synaptic inputs to VTA DA neurons.
Elife.
7
PMID: 29676731 -
Johnston et al.
(2018)
Activity in nodose ganglia neurons after treatment with CP 55,940 and cholecystokinin.
Physiol Rep.
6:e13927
PMID: 30512249 -
Song et al.
(2018)
Selective Role of RGS9-2 in Regulating Retrograde Synaptic Signaling of Indirect Pathway Medium Spiny Neurons in Dorsal Striatum.
J Neurosci.
38:7120
PMID: 30006367 -
Eubler et al.
(2018)
Ca2+ Signaling and IL-8 Secretion in Human Testicular Peritubular Cells Involve the Cation Channel TRPV2.
Int J Mol Sci.
19
PMID: 30235802 -
Han
(2017)
Cannabinoid receptor 1 contributes to sprouted innervation in endometrial ectopic growth through mitogen-activated protein kinase activation.
Brain Res.
1663:132
PMID: 28322749 -
King-Himmelreich
(2017)
AMPK contributes to aerobic exercise-induced antinociception downstream of endocannabinoids.
Neuropharmacology.
124:134
PMID: 28479394 -
Saliba
(2017)
AM404, paracetamol metabolite, prevents prostaglandin synthesis in activated microglia by inhibiting COX activity.
J Neuroinflammation.
14(1):246
PMID: 29237478 -
Zhang
(2017)
Orphan nuclear receptor ERRγ is a key regulator of human fibrinogen gene expression.
PLoS One.
12(7):e0182141
PMID: 28750085 -
Fatahi
(2017)
Involvement of cannabinoid system in the nucleus accumbens on delay-based decision making in the rat.
Behav Brain Res..
337:107
PMID: 28987618 -
Leroy et al.
(2017)
Input-Timing-Dependent Plasticity in the Hippocampal CA2 Region and Its Potential Role in Social Memory.
Neuron.
95:1089
PMID: 28823730 -
Shang et al.
(2016)
Δ 9-Tetrahydrocannabinol Reverses TNFα-induced Increase in Airway Epithelial Cell Permeability through CB 2 Receptors
Biochemical Pharmacology.
2016;
PMID: 27641813 -
Krohn et al.
(2016)
Abnormal cannabidiol attenuates experimental colitis in mice, promotes wound healing and inhibits neutrophil recruitment.
J Inflamm (Lond).
13:21
PMID: 27418880 -
Cui et al.
(2016)
Endocannabinoid dynamics gate spike-timing dependent depression and potentiation.
Elife.
5:e13185
PMID: 26920222 -
Blaha et al.
(2016)
Impaired Excitatory Neurotransmission in the Urinary Bladder from the Obese Zucker Rat: Role of Cannabinoid Receptors.
PLoS One.
11:e0157424
PMID: 27285468 -
Xie et al.
(2016)
Up-regulation of immunomodulatory effects of mouse bone-marrow derived mesenchymal stem cells by tetrahydrocannabinol pre-treatment involving cannabinoid receptor CB2.
Oncotarget.
7:6436
PMID: 26824325 -
Yu et al.
(2016)
Dentate cannabinoid-sensitive interneurons undergo unique and selective strengthening of mutual synaptic inhibition in experimental epilepsy.
Neurobiol Dis.
89:23
PMID: 26804027 -
Malek et al.
(2015)
Anandamide, Acting via CB2 Receptors, Alleviates LPS-Induced Neuroinflammation in Rat Primary Microglial Cultures.
Neural Plast.
2015:130639
PMID: 26090232 -
Zhang et al.
(2015)
Anoctamin Calcium-Activated Chloride Channels May Modulate Inhibitory Transmission in the Cerebellar Cortex.
PLoS One.
10:e0142160
PMID: 26558388 -
Yang et al.
(2015)
Cannabinoid receptor CB2 is involved in tetrahydrocannabinol-induced anti-inflammation against lipopolysaccharide in MG-63 cells.
Sci Rep.
2015:362126
PMID: 25653478 -
Liu et al.
(2015)
Involvement of GluR2 up-regulation in neuroprotection by electroacupuncture pretreatment via cannabinoid CB1 receptor in mice.
Nutr Diabetes.
5:9490
PMID: 25830356 -
Vähätalo et al.
(2015)
Role of the endocannabinoid system in obesity induced by neuropeptide Y overexpression in noradrenergic neurons.
Mol Cell Neurosci.
5:e151
PMID: 25915740 -
Zhou et al.
(2015)
Regional effects of endocannabinoid, BDNF and FGF receptor signalling on neuroblast motility and guidance along the rostral migratory stream.
Nat Commun.
64:32
PMID: 25481343 -
Dincheva et al.
(2015)
FAAH genetic variation enhances fronto-amygdala function in mouse and human.
Nat Commun.
6:6395
PMID: 25731744 -
Lenkey et al.
(2015)
Tonic endocannabinoid-mediated modulation of GABA release is independent of the CB1 content of axon terminals.
Sci Rep.
6:6557
PMID: 25891347 -
Smith et al.
(2015)
The Effects of the Endocannabinoids Anandamide and 2-Arachidonoylglycerol on Human Osteoblast Proliferation and Differentiation.
Proc Natl Acad Sci U S A.
10:e0136546
PMID: 26414859 -
Bowles et al.
(2015)
A peripheral endocannabinoid mechanism contributes to glucocorticoid-mediated metabolic syndrome.
Mol Pharmacol.
112:285
PMID: 25535367 -
Stanley et al.
(2015)
Cannabidiol causes endothelium-dependent vasorelaxation of human mesenteric arteries via CB1 activation.
Front Cell Neurosci.
107:568
PMID: 26092099 -
Martin et al.
(2015)
Endocannabinoids Mediate Muscarinic Acetylcholine Receptor-Dependent Long-Term Depression in the Adult Medial Prefrontal Cortex.
Br J Pharmacol.
9:457
PMID: 26648844 -
Krishnan and Chatterjee
(2015)
Differential immune mechanism to HIV-1 Tat variants and its regulation by AEA [corrected].
PLoS One.
5:9887
PMID: 25943894 -
Parvathy and Masocha
(2015)
Coadministration of indomet. and MinCyc attenuates established PacT.-induced neuropathic thermal hyperalgesia: Involvement of cannabinoid CB1 receptors.
J Neurosci.
5:10541
PMID: 26085115 -
Wang et al.
(2015)
Activation of cannabinoid receptor 1 inhibits increased bladder activity induced by nerve growth factor.
Neurosci Lett.
589:19
PMID: 25575795 -
Arrabal et al.
(2015)
Pharmacological Blockade of Cannabinoid CB1 Receptors in Diet-Induced Obesity Regulates Mitochondrial Dihydrolipoamide Dehydrogenase in Muscle.
PLoS One.
10:e0145244
PMID: 26671069 -
Bashashati et al.
(2015)
Inhibiting endocannabinoid biosynthesis: a novel approach to the treatment of constipation.
Br J Pharmacol.
172:3099
PMID: 25684407 -
Ma et al.
(2015)
Mitochondrial CB1 receptor is involved in ACEA-induced protective effects on neurons and mitochondrial functions.
Sci Rep.
5:12440
PMID: 26215450 -
Stornaiuolo et al.
(2015)
Endogenous vs Exogenous Allosteric Modulators in GPCRs: A dispute for shuttling CB1 among different membrane microenvironments.
Sci Rep.
5:15453
PMID: 26482099 -
Szabó et al.
(2014)
Presynaptic calcium channel inhibition underlies CB1 cannabinoid receptor-mediated suppression of GABA release.
Mediators Inflamm.
34:7958
PMID: 24899717 -
Alpár et al.
(2014)
Endocannabinoids modulate cortical development by configuring Slit2/Robo1 signalling.
J Neurosci.
5:4421
PMID: 25030704 -
Tortoriello et al.
(2014)
Miswiring the brain: △9-tetrahydrocannabinol disrupts cortical development by inducing an SCG10/stathmin-2 degradation pathway.
Proc Natl Acad Sci U S A.
33:668
PMID: 24469251 -
Hassanzadeh and Rostami
(2014)
CB1 cannabinoid receptors are involved in neuroleptic-induced enhancement of brain neurotensin.
J Neurosci.
17:181
PMID: 24847420 -
Costa et al.
(2014)
2-arachidonoylglycerol effects in cytotrophoblasts: metabolic enzymes expression and apoptosis in BeWo cells.
Reproduction.
147:301
PMID: 24324206 -
Cass et al.
(2014)
CB1 cannabinoid receptor stimulation during adolescence impairs the maturation of GABA function in the adult rat prefrontal cortex.
Mol Psychiatry.
19:536
PMID: 24589887 -
Xu et al.
(2014)
Hippocampal metaplasticity is required for the formation of temporal associative memories.
J Neurosci.
34:16762
PMID: 25505329 -
Kury et al.
(2014)
Effects of the endogenous cannabinoid anandamide on voltage-dependent sodium and calcium channels in rat ventricular myocytes.
Br J Pharmacol.
171:3485
PMID: 24758718 -
Sreevalsan and Safe
(2013)
The cannabinoid WIN 55,212-2 decreases specificity protein transcription factors and the oncogenic cap protein eIF4E in colon cancer cells.
Mol Cancer Ther.
12:2483
PMID: 24030632 -
Malenczyk et al.
(2013)
CB1 cannabinoid receptors couple to focal adhesion kinase to control Ins release.
J Biol Chem.
288:32685
PMID: 24089517 -
Abush and Akirav
(2013)
Cannabinoids ameliorate impairments induced by chronic stress to synaptic plasticity and short-term memory.
Neuropsychopharmacology.
38:1521
PMID: 23426383 -
Cao et al.
(2013)
Cannabinoid HU210 protects isolated rat stomach against impairment caused by serum of rats with experimental acute pancreatitis.
PLoS One.
7:e52921
PMID: 23285225 -
Wargent et al.
(2013)
The cannabinoid δ(9)-tetrahydrocannabivarin (THCV) ameliorates Ins sensitivity in two mouse models of obesity.
Nutr Diabetes.
3:e68
PMID: 23712280 -
Chanda et al.
(2013)
Hepatic cannabinoid receptor type 1 mediates alcohol-induced regulation of bile acid enzyme genes expression via CREBH.
PLoS One.
8:e68845
PMID: 23894352 -
Benz et al.
(2013)
Expression and functional relevance of cannabinoid receptor 1 in Hodgkin lymphoma.
PLoS One.
8:e81675
PMID: 24349109 -
Keimpema et al.
(2013)
Diacylglycerol lipase α manipulation reveals developmental roles for intercellular endocannabinoid signaling.
Nat Commun.
3:2093
PMID: 23806960 -
Baca et al.
(2013)
Gene-environment interactions affect long-term depression (LTD) through changes in DA receptor affinity in Snap25 deficient mice.
Brain Res.
1532:85
PMID: 23939223 -
Hayase
(2013)
Working memory- and anxiety-related behavioral effects of repeated nicotine as a stressor: the role of cannabinoid receptors.
BMC Neurosci.
14:20
PMID: 23394117 -
Li et al.
(2013)
Inhibition of fatty acid amide hydrolase activates Nrf2 signalling and induces heme oxygenase 1 transcription in breast cancer cells.
Br J Pharmacol.
170:489
PMID: 23347118 -
Duncan et al.
(2013)
Cannabinoid 1 receptors are critical for the innate immune response to TLR4 stimulation.
Am J Physiol Regul Integr Comp Physiol.
305:R224
PMID: 23739343 -
Rossi et al.
(2013)
The cannabinoid receptor type 2 as mediator of mesenchymal stromal cell immunosuppressive properties.
PLoS One.
8:e80022
PMID: 24312195 -
Ganon-Elazar and Akirav
(2012)
Cannabinoids prevent the development of behavioral and endocrine alterations in a rat model of intense stress.
Neuropsychopharmacology.
37:456
PMID: 21918506 -
Guida et al.
(2012)
Salvinorin A reduces mechanical allodynia and spinal neuronal hyperexcitability induced by peripheral formalin injection.
Mol Pain.
8:60
PMID: 22913292 -
Tozzi et al.
(2012)
A2A adenosine receptor antagonism enhances synaptic and motor effects of cocaine via CB1 cannabinoid receptor activation.
PLoS One.
7:e38312
PMID: 22715379 -
Caiati et al.
(2012)
Developmental regulation of CB1-mediated spike-time dependent depression at immature mossy fiber-CA3 synapses.
Sci Rep.
2:285
PMID: 22368777 -
Stern et al.
(2012)
On disruption of fear memory by reconsolidation blockade: evidence from cannabidiol treatment.
Neuropsychopharmacology.
37:2132
PMID: 22549120 -
Tumati et al.
(2012)
Repeated mor. treatment-mediated hyperalgesia, allodynia and spinal glial activation are blocked by co-administration of a selective cannabinoid receptor type-2 agonist.
J Neuroimmunol.
244:23
PMID: 22285397 -
Laricchiuta et al.
(2012)
CB1 receptor autoradiographic characterization of the individual differences in approach and avoidance motivation.
PLoS One.
7:e42111
PMID: 22848724 -
Brents et al.
(2012)
Monohydroxylated metabolites of the K2 synthetic cannabinoid JWH-073 retain intermediate to high cannabinoid 1 receptor (CB1R) affinity and exhibit neutral antagonist to partial agonist activity.
Biochem Pharmacol.
83:952
PMID: 22266354 -
Liu et al.
(2012)
Betulinic acid targets YY1 and ErbB2 through cannabinoid receptor-dependent disruption of microRNA-27a:ZBTB10 in breast cancer.
Mol Cancer Ther.
11:1421
PMID: 22553354 -
Casarotto et al.
(2012)
Opposing roles for cannabinoid receptor type-1 (CB1) and transient receptor potential vanilloid type-1 channel (TRPV1) on the modulation of panic-like responses in rats.
Pain.
37:478
PMID: 21937980 -
Niu et al.
(2012)
Effects of gonadal hormones on the peripheral cannabinoid receptor 1 (CB1R) system under a myositis condition in rats.
J Pharmacol Exp Ther.
153:2283
PMID: 22940464 -
Chanda et al.
(2012)
Activation of cannabinoid receptor type 1 (Cb1r) disrupts hepatic Ins receptor signaling via cyclic AMP-response element-binding protein H (Crebh)-mediated induction of Lipin1 gene.
Br J Pharmacol.
287:38041
PMID: 22989885 -
Gonzalez-Islas et al.
(2012)
Tonic and transient endocannabinoid regulation of AMPAergic miniature postsynaptic currents and homeostatic plasticity in embryonic motor networks.
Sci Rep.
32:13597
PMID: 23015449 -
Giordano et al.
(2012)
TRPV1-dependent and -independent alterations in the limbic cortex of neuropathic mice: impact on glial caspases and pain perception.
Cereb Cortex.
22:2495
PMID: 22139792 -
Laricchiuta et al.
(2012)
Differences in spontaneously avoiding or approaching mice reflect differences in CB1-mediated signaling of dorsal striatal transmission.
PLoS One.
7:e33260
PMID: 22413007 -
Merighi et al.
(2012)
Cannabinoid CB(2) receptors modulate ERK-1/2 kinase signalling and NO release in microglial cells stimulated with bacterial lipopolysaccharide.
Br J Pharmacol.
165:1773
PMID: 21951063 -
Peterfi et al.
(2012)
Endocannabinoid-mediated long-term depression of afferent excitatory synapses in hippocampal pyramidal cells and GABAergic interneurons.
J Neurosci.
32:14448
PMID: 23055515 -
Sideris et al.
(2012)
A Role for the Cannabinoid 1 Receptor in Neuronal Differentiation of Adult Spinal Cord Progenitors in vitro is Revealed through Pharmacological Inhibition and Genetic Deletion.
Front Neurosci.
6:4
PMID: 22291615 -
Tauber et al.
(2012)
Regulation of MMP-9 by a WIN-binding site in the monocyte-macrophage system independent from cannabinoid receptors.
PLoS One.
7:e48272
PMID: 23139770 -
Hamtiaux et al.
(2012)
The association of N-palmitoylethanolamine with the FAAH inhibitor URB597 impairs melanoma growth through a supra-additive action.
BMC Cancer.
12:92
PMID: 22429826 -
Aydin et al.
(2012)
Nicotine-induced anxiety-like behavior in a rat model of the novelty-seeking phenotype is associated with long-lasting neuropeptidergic and neuroplastic adaptations in the amygdala: effects of the cannabinoid receptor 1 antagonist AM251.
Neuropharmacology.
63:1335
PMID: 22959963 -
Baur et al.
(2012)
The cannabinoid CB1 receptor antagonists rim. (SR141716) and AM251 directly potentiate GABA(A) receptors.
Br J Pharmacol.
165:2479
PMID: 21470203 -
Merighi et al.
(2012)
Cannabinoid CB(2) receptor attenuates morphine-induced inflammatory responses in activated microglial cells.
Br J Pharmacol.
166:2371
PMID: 22428664 -
Méndez-D?az et al.
(2012)
The endocannabinoid system modulates the valence of the emotion associated to food ingestion.
Addict Biol.
17:725
PMID: 21182571 -
Li and Burrell
(2011)
Associative, bidirectional changes in neural signaling utilizing NMDA receptor- and endocannabinoid-dependent mechanisms.
Learn Mem.
18:545
PMID: 21844187 -
Brents et al.
(2011)
Phase I hydroxylated metabolites of the K2 synthetic cannabinoid JWH-018 retain in vitro and in vivo cannabinoid 1 receptor affinity and activity.
PLoS One.
6:e21917
PMID: 21755008 -
Crespillo et al.
(2011)
Expression of the cannabinoid system in muscle: effects of a high-fat diet and CB1 receptor blockade.
Biochem J.
433:175
PMID: 20955176 -
Pan et al.
(2011)
Alterations of endocannabinoid signaling, synaptic plasticity, learning, and memory in monoacylglycerol lipase knock-out mice.
J Cell Biol.
31:13420
PMID: 21940435 -
Hassanzadeh and Hassanzadeh
(2011)
The Role of the Endocannabinoids in Suppression of the Hypothalamic-pituitary-adrenal Axis Activity by dox.
J Leukoc Biol.
14:414
PMID: 23493814 -
Negrete et al.
(2011)
The antinociceptive effects of JWH-015 in chronic inflammatory pain are produced by nitric oxide-cGMP-PKG-KATP pathway activation mediated by opioids.
PLoS One.
6:e26688
PMID: 22031841 -
Guidali et al.
(2011)
Cannabinoid CB1 receptor antagonism prevents neurochemical and behavioural deficits induced by chronic phencyclidine.
Int J Neuropsychopharmacol.
14:17
PMID: 20196921 -
Segev and Akirav
(2011)
Differential effects of cannabinoid receptor agonist on social discrimination and contextual fear in amygdala and hippocampus.
Learn Mem.
18:254
PMID: 21447623 -
Samineni et al.
(2011)
Post-ictal analgesia in genetically epilepsy-prone rats is induced by audiogenic seizures and involves cannabinoid receptors in the periaqueductal gray.
Brain Res.
1389:177
PMID: 21439272 -
Thompson and Perkel
(2011)
Endocannabinoids mediate synaptic plasticity at glutamatergic synapses on spiny neurons within a basal ganglia nucleus necessary for song learning.
J Neurophysiol.
105:1159
PMID: 21177997 -
Sousa et al.
(2011)
Regulation of hippocampal cannabinoid CB1 receptor actions by adenosine A1 receptors and chronic caffeine administration: implications for the effects of δ9-tetrahydrocannabinol on spatial memory.
Neuropsychopharmacology.
36:472
PMID: 20927050 -
Ruby et al.
(2011)
Acute overactive endocannabinoid signaling induces glucose intolerance, hepatic steatosis, and novel cannabinoid receptor 1 responsive genes.
PLoS One.
6:e26415
PMID: 22073164 -
Novellis et al.
(2011)
The blockade of the transient receptor potential vanilloid type 1 and fatty acid amide hydrolase decreases symptoms and central sequelae in the medial prefrontal cortex of neuropathic rats.
Mol Pain.
7:7
PMID: 21241462 -
Hamtiaux et al.
(2011)
Increasing antiproliferative properties of endocannabinoids in N1E-115 neuroblastoma cells through inhibition of their metabolism.
PLoS One.
6:e26823
PMID: 22046372 -
Yuan and Burrell
(2010)
Endocannabinoid-dependent LTD in a nociceptive synapse requires activation of a presynaptic TRPV-like receptor.
J Neurophysiol.
104:2766
PMID: 20884761 -
Jiang et al.
(2010)
The maturation of GABAergic transmission in visual cortex requires endocannabinoid-mediated LTD of inhibitory inputs during a critical period.
Neuron.
66:248
PMID: 20435001 -
Buznikov et al.
(2010)
A putative 'pre-nervous' endocannabinoid system in early echinoderm development.
Dev Neurosci.
32:1
PMID: 19907129 -
Mair et al.
(2010)
Interaction between anandamide and sphingosine-1-phosphate in mediating vasorelaxation in rat coronary artery.
Br J Pharmacol.
161:176
PMID: 20718749 -
Atkinson et al.
(2010)
Regulation of the hypothalamic-pituitary-adrenal axis circadian rhythm by endocannabinoids is sexually diergic.
Endocrinology.
151:3720
PMID: 20534730 -
Schlosburg et al.
(2010)
Chronic monoacylglycerol lipase blockade causes functional antagonism of the endocannabinoid system.
Nat Neurosci.
13:1113
PMID: 20729846 -
Henstridge et al.
(2010)
GPR55 ligands promote receptor coupling to multiple signalling pathways.
Br J Pharmacol.
160:604
PMID: 20136841 -
Curto-Reyes et al.
(2010)
Spinal and peripheral analgesic effects of the CB2 cannabinoid receptor agonist AM1241 in two models of bone cancer-induced pain.
Br J Pharmacol.
160:561
PMID: 20233215 -
Acuna-Goycolea et al.
(2010)
Cannabinoids excite circadian clock neurons.
J Neurosci.
30:10061
PMID: 20668190 -
Farkas et al.
(2010)
Retrograde endocannabinoid signaling reduces GABAergic synaptic transmission to gonadotropin-releasing hormone neurons.
J Biol Chem.
151:5818
PMID: 20926585 -
Jones et al.
(2010)
Cannabidiol displays antiepileptiform and antiseizure properties in vitro and in vivo.
Cereb Cortex.
332:569
PMID: 19906779 -
Ho et al.
(2010)
Endocannabinoid modulation of hyperaemia evoked by physiologically relevant stimuli in the rat primary somatosensory cortex.
Neuropsychopharmacology.
160:736
PMID: 20590576 -
Hao et al.
(2010)
The cannabinoid WIN55,212-2 protects against oxidized LDL-induced inflammatory response in murine macrophages.
Iran J Basic Med Sci.
51:2181
PMID: 20305287 -
Bhaskaran and Smith
(2010)
Effects of TRPV1 activation on synaptic excitation in the dentate gyrus of a mouse model of temporal lobe epilepsy.
Endocrinology.
223:529
PMID: 20144892 -
Wamsteeker et al.
(2010)
Repeated stress impairs endocannabinoid signaling in the paraventricular nucleus of the hypothalamus.
J Neurosci.
30:11188
PMID: 20720126 -
Huang et al.
(2010)
A refractory period for rejuvenating GABAergic synaptic transmission and ocular dominance plasticity with dark exposure.
J Neurosci.
30:16636
PMID: 21148002 -
Losonczy et al.
(2010)
Network mechanisms of theta related neuronal activity in hippocampal CA1 pyramidal neurons.
Nat Neurosci.
13:967
PMID: 20639875 -
Touriño et al.
(2010)
THC Prevents MDMA Neurotoxicity in Mice.
PLoS One.
5:e9143
PMID: 20174577 -
Hoffman et al.
(2010)
Control of cannabinoid CB1 receptor function on glutamate axon terminals by endogenous adenosine acting at A1 receptors.
J Neurosci.
30:545
PMID: 20071517 -
Godlewski et al.
(2010)
Inhibitor of fatty acid amide hydrolase normalizes cardiovascular function in hypertension without adverse metabolic effects.
Chem Biol.
17:1256
PMID: 21095576 -
Zhang et al.
(2010)
Cannabinoid CB1 receptor facilitation of substance P release in the rat spinal cord, measured as neurokinin 1 receptor internalization.
Eur J Neurosci.
31:225
PMID: 20074214 -
Garzón et al.
(2009)
Gz mediates the long-lasting desensitization of brain CB1 receptors and is essential for cross-tolerance with mor.
Mol Pain.
5:11
PMID: 19284549 -
Mendiguren and Pineda
(2009)
Effect of the CB(1) receptor antagonists rim. and AM251 on the firing rate of dorsal raphe nucleus neurons in rat brain slices.
Br J Pharmacol.
158:1579
PMID: 19845674 -
Tjen-A-Looi et al.
(2009)
Processing cardiovascular information in the vlPAG during electroacupuncture in rats: roles of endocannabinoids and GABA.
J Appl Physiol (1985).
106:1793
PMID: 19325030 -
Fraga et al.
(2009)
Endogenous cannabinoids induce fever through the activation of CB1 receptors.
Neuropsychopharmacology.
157:1494
PMID: 19681872 -
Meuth et al.
(2009)
The neuroprotective impact of the leak potassium channel TASK1 on stroke development in mice.
Exp Neurol.
33:42675
PMID: 18930826 -
Wallace et al.
(2009)
PKCε regulates behavioral sensitivity, binding and tolerance to the CB1 receptor agonist WIN55,212-2.
Iran J Basic Med Sci.
34:1733
PMID: 19158669 -
Ho and Gardiner
(2009)
Acute hypertension reveals depressor and vasodilator effects of cannabinoids in conscious rats.
Br J Pharmacol.
156:94
PMID: 19133994 -
Pan et al.
(2009)
Blockade of 2-arachidonoylglycerol hydrolysis by selective monoacylglycerol lipase inhibitor 4-nitrophenyl 4-(dibenzo[d][1,3]dioxol-5-yl(hydroxy)methyl)piperidine-1-carboxylate (JZL184) Enhances retrograde endocannabinoid signaling.
J Pharmacol Exp Ther.
331:591
PMID: 19666749 -
Pacheco et al.
(2009)
Central antinociception induced by mu-opioid receptor agonist morphine, but not delta- or kappa-, is mediated by cannabinoid CB1 receptor.
Br J Pharmacol.
158:225
PMID: 19594755 -
Shen et al.
(2008)
Dichotomous DArgic control of striatal synaptic plasticity.
Science.
321:848
PMID: 18687967 -
Gibson et al.
(2008)
TRPV1 channels mediate long-term depression at synapses on hippocampal interneurons.
Neuron.
57:746
PMID: 18341994 -
Melis et al.
(2008)
Endogenous fatty acid ethanolamides suppress nicotine-induced activation of mesolimbic DA neurons through nuclear receptors.
J Neurosci.
28:13985
PMID: 19091987 -
Potenzieri et al.
(2008)
The cannabinoid receptor agonist, WIN 55, 212-2, attenuates tumor-evoked hyperalgesia through peripheral mechanisms.
Brain Res.
1215:69
PMID: 18486111 -
Börner et al.
(2008)
Analysis of promoter regions regulating basal and interleukin-4-inducible expression of the human CB1 receptor gene in T lymphocytes.
Eur J Pharmacol.
73:1013
PMID: 18156315 -
Georgieva et al.
(2008)
Unique agonist-bound cannabinoid CB1 receptor conformations indicate agonist specificity in signaling.
Br J Pharmacol.
581:19
PMID: 18162180 -
Giannini et al.
(2008)
Activation of cannabinoid receptors prevents antigen-induced asthma-like reaction in guinea pigs.
Br J Pharmacol.
12:2381
PMID: 18266975 -
Desroches et al.
(2008)
Modulation of the anti-nociceptive effects of 2-arachidonoyl glycerol by peripherally administered FAAH and MGL inhibitors in a neuropathic pain model.
Eur J Neurosci.
155:913
PMID: 18695638 -
Naguib et al.
(2008)
MDA7: a novel selective agonist for CB2 receptors that prevents allodynia in rat neuropathic pain models.
Br J Pharmacol.
155:1104
PMID: 18846037 -
Xia et al.
(2008)
Electroacupuncture of 2?hz has a rewarding effect: evidence from a conditioned place preference study in rats.
Evid Based Complement Alternat Med.
2011:730514
PMID: 18955347 -
Ruby et al.
(2008)
Overactive endocannabinoid signaling impairs apolipoprotein E-mediated clearance of triglyceride-rich lipoproteins.
Proc Natl Acad Sci U S A.
105:14561
PMID: 18794527 -
Wilson et al.
(2008)
Repeated cannabinoid injections into the rat periaqueductal gray enhance subsequent mor. antinociception.
Neuropharmacology.
55:1219
PMID: 18723035 -
Durakoglugil and Orer
(2008)
Cannabinoid receptor activation in the nucleus tractus solitaries produces baroreflex-like responses in the rat.
Int J Biomed Sci.
4:229
PMID: 23675095 -
Toscano et al.
(2008)
Altered GABAergic neurotransmission is associated with increased kainate-induced seizure in prostaglandin-endoperoxide synthase-2 deficient mice.
Brain Res Bull.
75:598
PMID: 18355636 -
Huang et al.
(2008)
Roles of endocannabinoids in heterosynaptic long-term depression of excitatory synaptic transmission in visual cortex of young mice.
J Neurosci.
28:7074
PMID: 18614676 -
Pacheco et al.
(2008)
The mu-opioid receptor agonist morphine, but not agonists at delta- or kappa-opioid receptors, induces peripheral antinociception mediated by cannabinoid receptors.
Br J Pharmacol.
154:1143
PMID: 18469844 -
Kim et al.
(2008)
Interactions between CB(1) receptors and TRPV1 channels mediated by 12-HPETE are cytotoxic to mesencephalic DArgic neurons.
Br J Pharmacol.
155:253
PMID: 18552868 -
Crozier et al.
(2007)
Deprivation-induced synaptic depression by distinct mechanisms in different layers of mouse visual cortex.
Proc Natl Acad Sci U S A.
104:1383
PMID: 17227847 -
Huang et al.
(2007)
Cannabinoids excite hypothalamic melanin-concentrating hormone but inhibit hypocretin/orexin neurons: implications for cannabinoid actions on food intake and cognitive arousal.
J Neurosci.
27:4870
PMID: 17475795 -
Czesnik et al.
(2007)
Cannabinoid action in the olfactory epithelium.
Proc Natl Acad Sci U S A.
104:2967
PMID: 17301239 -
Kelm et al.
(2007)
Calcium release from presynaptic internal stores is required for ethanol to increase spontaneous γ-aminobutyric acid release onto cerebellum Purkinje neurons.
PLoS One.
323:356
PMID: 17652632 -
Saitoh et al.
(2007)
The differential contractile responses to capsaicin and anandamide in muscle strips isolated from the rat urinary bladder.
J Neurosci.
570:182
PMID: 17586490 -
Ghasemi et al.
(2007)
Role of the nitric oxide pathway and the endocannabinoid system in neurogenic relaxation of corpus cavernosum from biliary cirrhotic rats.
EMBO J.
151:591
PMID: 17486141 -
Bátkai et al.
(2007)
Endocannabinoids acting at CB1 receptors mediate the cardiac contractile dysfunction in vivo in cirrhotic rats.
Br J Pharmacol.
293:H1689
PMID: 17557913 -
Rajesh et al.
(2007)
Cannabinoid-2 receptor agonist HU-308 protects against hepatic ischemia/reperfusion injury by attenuating oxidative stress, inflammatory response, and apoptosis.
Cardiovasc Res.
82:1382
PMID: 17652447 -
Fortin and Levine
(2007)
Differential effects of endocannabinoids on glutamatergic and GABAergic inputs to layer 5 pyramidal neurons.
J Biol Chem.
17:163
PMID: 16467564 -
Cachope et al.
(2007)
Potentiation of electrical and chemical synaptic transmission mediated by endocannabinoids.
Neuron.
56:1034
PMID: 18093525 -
Makara et al.
(2007)
Involvement of nitric oxide in depolarization-induced suppression of inhibition in hippocampal pyramidal cells during activation of cholinergic receptors.
J Neurosci.
27:10211
PMID: 17881527 -
Hoffman et al.
(2007)
Opposing actions of chronic Delta9-tetrahydrocannabinol and cannabinoid antagonists on hippocampal long-term potentiation.
Learn Mem.
14:63
PMID: 17202425 -
Deshpande et al.
(2007)
Development of pharmacoresistance to benzodiazepines but not cannabinoids in the hippocampal neuronal culture model of status epilepticus.
Exp Neurol.
204:705
PMID: 17289026 -
Hama
(2007)
Antinociceptive effect of cannabinoid agonist WIN 55,212-2 in rats with a spinal cord injury.
Exp Neurol.
204:454
PMID: 17045264 -
Wang et al.
(2006)
DArgic control of corticostriatal long-term synaptic depression in medium spiny neurons is mediated by cholinergic interneurons.
Neuron.
50:443
PMID: 16675398 -
Bender et al.
(2006)
Two coincidence detectors for spike timing-dependent plasticity in somatosensory cortex.
J Neurosci.
26:4166
PMID: 16624937 -
Cenni et al.
(2006)
Differential effect of cannabinoid agonists and endocannabinoids on histamine release from distinct regions of the rat brain.
Eur J Neurosci.
24:1633
PMID: 17004927 -
Moezi et al.
(2006)
Anandamide mediates hyperdynamic circulation in cirrhotic rats via CB(1) and VR(1) receptors.
J Neurosci.
149:898
PMID: 17043671 -
Derbenev et al.
(2006)
Vanilloid-mediated heterosynaptic facilitation of inhibitory synaptic input to neurons of the rat dorsal motor nucleus of the vagus.
PLoS One.
26:9666
PMID: 16988037 -
Kurihara et al.
(2006)
Effects of peripheral cannabinoid receptor ligands on motility and polarization in neutrophil-like HL60 cells and human neutrophils.
Br J Pharmacol.
281:12908
PMID: 16513651 -
Jayamanne et al.
(2006)
Actions of the FAAH inhibitor URB597 in neuropathic and inflammatory chronic pain models.
J Neurosci.
147:281
PMID: 16331291 -
Lin et al.
(2006)
Effects of intra-amygdala infusion of CB1 receptor agonists on the reconsolidation of fear-potentiated startle.
Learn Mem.
13:316
PMID: 16705137 -
Nieri et al.
(2006)
Modulation of P-glycoprotein activity by cannabinoid molecules in HK-2 renal cells.
Br J Pharmacol.
148:682
PMID: 16715117 -
Laviolette
(2006)
Cannabinoids Potentiate Emotional Learning Plasticity in Neurons of the Medial Prefrontal Cortex through Basolateral Amygdala Inputs.
J Neurosci.
26:6458
PMID: 16775133 -
Safo and Regehr
(2005)
Endocannabinoids control the induction of cerebellar LTD.
Neuron.
48:647
PMID: 16301180 -
Berghuis et al.
(2005)
Endocannabinoids regulate interneuron migration and morphogenesis by transactivating the TrkB receptor.
Neurobiol Dis.
102:19115
PMID: 16357196 -
Gaskari et al.
(2005)
Role of endocannabinoids in the pathogenesis of cirrhotic cardiomyopathy in bile duct-ligated rats.
Sci Rep.
146:315
PMID: 16025138 -
Hoffman et al.
(2005)
Species and strain differences in the expression of a novel glutamate-modulating cannabinoid receptor in the rodent hippocampus.
Am J Physiol Heart Circ Physiol.
22:2387
PMID: 16262678 -
Pacher et al.
(2005)
Hemodynamic profile, responsiveness to anandamide, and baroreflex sensitivity of mice lacking fatty acid amide hydrolase.
J Lipid Res.
289:H533
PMID: 15821037 -
de Oliveira Alvares et al.
(2005)
Amnestic effect of intrahippocampal AM251, a CB1-selective blocker, in the inhibitory avoidance, but not in the open field habituation task, in rats.
Neurobiol Learn Mem.
83:119
PMID: 15721795 -
Kettunen et al.
(2005)
Neuromodulation via conditional release of endocannabinoids in the spinal locomotor network.
Neuron.
45:95
PMID: 15629705 -
Haj-Dahmane
(2005)
The wake-promoting peptide orexin-B inhibits glutamatergic transmission to dorsal raphe nucleus serotonin neurons through retrograde endocannabinoid signaling.
J Neurosci.
25:896
PMID: 15673670 -
Akerman et al.
(2004)
Anandamide acts as a vasodilator of dural blood vessels in vivo by activating TRPV1 receptors.
Br J Pharmacol.
142:1354
PMID: 15277315 -
Melyan et al.
(2004)
Metabotropic regulation of intrinsic excitability by synaptic activation of kainate receptors.
J Neurosci.
24:4530
PMID: 15140923 -
Mathison et al.
(2004)
Effects of cannabinoid receptor-2 activation on accelerated gastrointestinal transit in lipopolysaccharide-treated rats.
Br J Pharmacol.
142:1247
PMID: 15249429 -
Price et al.
(2004)
Cannabinoid receptor-independent actions of the aminoalkylindole WIN 55,212-2 on trigeminal sensory neurons.
Br J Pharmacol.
142:257
PMID: 15155534 -
Chevaleyre and Castillo
(2004)
Endocannabinoid-mediated metaplasticity in the hippocampus.
Neuron.
43:871
PMID: 15363397 -
Galarreta et al.
(2004)
Electrical coupling among irregular-spiking GABAergic interneurons expressing cannabinoid receptors.
J Pharmacol Exp Ther.
24:9770
PMID: 15525762 -
Harkany et al.
(2004)
Endocannabinoid-independent retrograde signaling at inhibitory synapses in layer 2/3 of neocortex: involvement of vesicular glutamate transporter 3.
Circulation.
24:4978
PMID: 15163690 -
Bátkai et al.
(2004)
Endocannabinoids acting at cannabinoid-1 receptors regulate cardiovascular function in hypertension.
Eur J Pharmacol.
110:1996
PMID: 15451779 -
Scorticati et al.
(2004)
The inhibitory effect of anandamide on luteinizing hormone-releasing hormone secretion is reversed by estrogen.
Mol Pharmacol.
101:11891
PMID: 15280536 -
Jin et al.
(2004)
Defective adult neurogenesis in CB1 cannabinoid receptor knockout mice.
Am J Physiol Heart Circ Physiol.
66:204
PMID: 15266010 -
Vannacci et al.
(2004)
The endocannabinoid 2-arachidonylglycerol decreases the immunological activation of Guinea pig mast cells: involvement of nitric oxide and eicosanoids.
J Pharmacol Exp Ther.
311:256
PMID: 15187170 -
Baker
(2004)
The cannabinomimetic arachidonyl-2-chloroethylamide (ACEA) acts on capsaicin-sensitive TRPV1 receptors but not cannabinoid receptors in rat joints.
Br J Pharmacol.
142:1361
PMID: 15277316 -
Savinainen et al.
(2003)
An optimized approach to study endocannabinoid signaling: evidence against constitutive activity of rat brain adenosine A1 and cannabinoid CB1 receptors.
Br J Pharmacol.
140:1451
PMID: 14623770 -
Williams et al.
(2003)
The FGF receptor uses the endocannabinoid signaling system to couple to an axonal growth response.
J Cell Mol Med.
160:481
PMID: 12578907 -
Ford et al.
(2002)
Evidence of a novel site mediating anandamide-induced negative inotropic and coronary vasodilatator responses in rat isolated hearts.
Br J Pharmacol.
135:1191
PMID: 11877326 -
Savinainen et al.
(2001)
Despite substantial degradation, 2-arachidonoylglycerol is a potent full efficacy agonist mediating CB(1) receptor-dependent G-protein activation in rat cerebellar membranes.
Br J Pharmacol.
134:664
PMID: 11588122 -
Stanford et al.
(2001)
Identification of two distinct vasodilator pathways activated by ATP in the mesenteric bed of the rat.
Br J Pharmacol.
133:825
PMID: 11454655 -
Jiang et al.
Expression and function of cannabinoid receptors CB1 and CB2 and their cognate cannabinoid ligands in murine embryonic stem cells.
PLoS One.
2:e641
PMID: 17653268 -
Lafourcade et al.
Molecular components and functions of the endocannabinoid system in mouse prefrontal cortex.
PLoS One.
2:e709
PMID: 17684555 -
Kola et al.
The orexigenic effect of ghrelin is mediated through central activation of the endogenous cannabinoid system.
Br J Pharmacol.
3:e1797
PMID: 18335063 -
Sinnayah et al.
Feeding induced by cannabinoids is mediated independently of the melanocortin system.
Proc Natl Acad Sci U S A.
3:e2202
PMID: 18493584
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