Oleylethanolamide
Tocris Bioscience, part of Bio-Techne | Catalog # 1484
Lipid mediator, anorexic actions; also GPR55 and PPARα agonist
Key Product Details
Description
Lipid mediator, anorexic actions; also GPR55 and PPARα agonist
Product Description
Oleylethanolamide is a lipid mediator and analog of anandamide (Cat. No. 1339) that is involved in peripheral regulation of feeding. Selective GPR55 agonist (EC50 values are 0.44, >30 and >30 μM at GPR55, CB1 and CB2 respectively) and PPARα agonist (EC50 = 120 nM). Induces satiety through activation of PPARα and is also a ceramidase inhibitor. Also endogenous agonist at the GPR119 receptor.Product Specifications
Molecular Weight
325.53
Formula
C20H39NO2
Storage
Store at +4°C
Purity
≥99% (HPLC)
Chemical Name
(9Z)-N-(2-Hydroxyethyl)-9-octadecenamide
CAS Number
111-58-0
PubChem ID
5283454
InChI Key
BOWVQLFMWHZBEF-KTKRTIGZSA-N
SMILES
CCCCCCCC\C=C/CCCCCCCC(=O)NCCO
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
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Background References
References are publications that support the biological activity of the product.
- Ryberg The orphan receptor GPR55 is a novel cannabinoid receptor. Br.J.Pharmacol. 2007 PMID: 17876302
- Fu Oleylethanolamide regulates feeding and body weight through activation of the nuclear receptor PPAR-α. Nature 2003 PMID: 12955147
- Coroneos Differential regulation of sphingomyelinase and ceramidase activities by growth factors and cytokines. J.Biol.Chem. 1995 PMID: 7559485
- de Fonseca An anorexic lipid mediator regulated by feeding. Nature 2001 PMID: 11700558
- Calignano Antinociceptive activity of the endogenous fatty acid amide, palmitylethanolamide. Eur.J.Pharmacol. 2001 PMID: 11426841
Product Specific Notices for Oleylethanolamide
For research use only
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