ML 184
Tocris Bioscience, part of Bio-Techne | Catalog # 6668
Selective GPR55 agonist; also promotes NSC proliferation and differentiation
Key Product Details
Description
Selective GPR55 agonist; also promotes NSC proliferation and differentiation
Alternative Names
CID 20440433
Product Description
ML 184 is a selective GPR55 agonist (EC50 = 250 nM). Exhibits >100-fold selectivity for GPR55 over GPR35, CB1 and CB2. Increases proliferation of neural stem cells and promotes neuronal differentiation in vitro.Product Specifications
Molecular Weight
470.63
Formula
C25H34N4O3S
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
3-[[4-(2,3-Dimethylphenyl)-1-piperazinyl]carbonyl]-N,N-dimethyl-4-(1-pyrrolidinyl)benzenesulfonamide
CAS Number
794572-10-4
PubChem ID
2440433
InChI Key
VRSJAHQGJHDACS-UHFFFAOYSA-N
SMILES
CN(S(=O)(C1=CC(C(N2CCN(C3=C(C(C)=CC=C3)C)CC2)=O)=C(N4CCCC4)C=C1)=O)C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 9.41 | 20 |
Preparing Stock Solutions
for ML 184
The following data is based on the product molecular weight 470.63
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.2 mM | 10.62 mL | 53.12 mL | 106.24 mL |
| 1 mM | 2.12 mL | 10.62 mL | 21.25 mL |
| 2 mM | 1.06 mL | 5.31 mL | 10.62 mL |
| 10 mM | 0.21 mL | 1.06 mL | 2.12 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Kotsikorou Identification of the GPR55 agonist binding site using a novel set of high-potency GPR55 selective ligands. Biochemistry 2011 PMID: 21534610
- Hill Activation of GPR55 increases neural stem cell proliferation and promotes early adult hippocampal neurogenesis. Br.J.Pharmacol. 2018 PMID: 29888782
Product Specific Notices for ML 184
For research use only
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