O-1602
Tocris Bioscience, part of Bio-Techne | Catalog # 2797
Potent GPR55 agonist
Product Description
O-1602 is an analog of cannabidiol that is a potent agonist at the GPR55 cannabinoid receptor (EC50 values are 13, > 30000 and > 30000 nM for GPR55, CB1 and CB2 receptors respectively). Induces activation of RhoA, cdc42 and rac1. Increases proliferation of neural stem cells NSCs in vitro and in vivo. Also promotes neurogenesis in vivo.Product Specifications
Molecular Weight
258.36
Formula
C17H22O2
Storage
Store at -20°C
Purity
≥97% (HPLC)
Chemical Name
5-Methyl-4-[(1R,6R)-3-methyl-6-(1-methylethenyl)-2-cyclohexen-1-yl]-1,3-benzenediol
CAS Number
317321-41-8
PubChem ID
45073499
InChI Key
KDZOUSULXZNDJH-LSDHHAIUSA-N
SMILES
C=[C@](C)[C@@H]1CCC(C)=C[C@H]1[C@]2=C(O)C=C(O)C=C2C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solubility | Soluble in methyl acetate (supplied pre-dissolved -10mg/ml) |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Johns The novel endocannabinoid receptor GPR55 is activated by atypical cannabinoids but does not mediate their vasodilator effects. Br.J.Pharmacol. 2007 PMID: 17704827
- Hill Activation of GPR55 increases neural stem cell proliferation and promotes early adult hippocampal neurogenesis. Br.J.Pharmacol. 2018 PMID: 29888782
- Ryberg The orphan receptor GPR55 is a novel cannabinoid receptor. Br.J.Pharmacol. 2007 PMID: 17876302
Product Specific Notices for O-1602
For research use only
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