2-Arachidonylglycerol
Catalog # 1298 | Tocris Bioscience a Bio-Techne Brand
Endogenous and non-selective CB agonist; potent GPR55 agonist
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Key Product Details
Description: | Endogenous and non-selective CB agonist; potent GPR55 agonist |
Alternative Names: | 2-AG, Arachidonoylglycerol |
Chemical Name: | (5Z,8Z,11Z,14Z)-5,8,11,14-Eicosatetraenoic acid, 2-hydroxy-1-(hydroxymethyl)ethyl ester |
Molecular Weight: | 378.55 |
Citations for 2-Arachidonylglycerol (22)
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Citations are publications that use Bio-Techne products. Selected citations for 2-Arachidonylglycerol include:
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Ellermann et al.
(2020)
Endocannabinoids inhibit the induction of virulence in enteric pathogens.
Cell.
2020;
PMID: 33031742 -
Hu et al.
(2019)
Endocannabinoid Signaling Mediates Local Dendritic Coordination between Excitatory and Inhibitory Synapses.
Cell Rep.
27:666
PMID: 30995465 -
Nogueras-Ortiz
(2017)
Retromer stops beta-arrestin 1 mediated signaling from internalized cannabinoid 2 receptors.
Mol Biol Cell.
28(24):3554
PMID: 28954865 -
Wu and Tasker
(2017)
Nongenomic Glucocorticoid Suppression of a Postsynaptic Potassium Current via Emergent Autocrine Endocannabinoid Signaling in Hypothalamic Neuroendocrine Cells following Chronic Dehydration.
Eneuro.
4
PMID: 28966975 -
Petrosino et al.
(2016)
The anti-inflammatory mediator palmitoylethanolamide enhances the levels of 2-arachidonoyl-glycerol and potentiates its actions at TRPV1 cation channels.
Br J Pharmacol.
173:1154
PMID: 25598150 -
Mounsey et al.
(2015)
Increasing levels of the endocannabinoid 2-AG is neuroprotective in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease.
Pharmacol Res.
273:36
PMID: 26244281 -
Lin et al.
(2014)
Diacylglycerol lipase regulates lifespan and oxidative stress response by inversely modulating TOR signaling in Drosophila and C. elegans.
Aging Cell.
13:755
PMID: 24889782 -
Flores-Otero et al.
(2014)
Ligand-specific endocytic dwell times control functional selectivity of the cannabinoid receptor 1.
Nat Commun.
5:4589
PMID: 25081814 -
Higgins et al.
(2013)
Differential modulation of nociceptive versus non-nociceptive synapses by endocannabinoids.
Mol Pain.
9:26
PMID: 23725095 -
Valdeolivas et al.
(2013)
The inhibition of 2-arachidonoyl-glycerol (2-AG) biosynthesis, rather than enhancing striatal damage, protects striatal neurons from malonate-induced death: a potential role of cyclooxygenase-2-dependent metabolism of 2-AG.
Br J Pharmacol.
4:e862
PMID: 24136226 -
Chanda et al.
(2012)
Activation of cannabinoid receptor type 1 (Cb1r) disrupts hepatic Ins receptor signaling via cyclic AMP-response element-binding protein H (Crebh)-mediated induction of Lipin1 gene.
J Cell Biol.
287:38041
PMID: 22989885 -
Khasabova et al.
(2011)
Increasing 2-arachidonoyl glycerol signaling in the periphery attenuates mechanical hyperalgesia in a model of bone cancer pain.
J Biol Chem.
64:60
PMID: 21440630 -
Guindon et al.
(2011)
Peripheral antinociceptive effects of inhibitors of monoacylglycerol lipase in a rat model of inflammatory pain.
Br J Pharmacol.
163:1464
PMID: 21198549 -
Yuan and Burrell
(2010)
Endocannabinoid-dependent LTD in a nociceptive synapse requires activation of a presynaptic TRPV-like receptor.
J Neurophysiol.
104:2766
PMID: 20884761 -
Wang et al.
(2009)
Pretreatment with electroacupuncture induces rapid tolerance to focal cerebral ischemia through regulation of endocannabinoid system.
Stroke.
40:2157
PMID: 19372445 -
Carney et al.
(2009)
Cannabinoid regulation of nitric oxide synthase I (nNOS) in neuronal cells.
J Neuroimmune Pharmacol.
4:338
PMID: 19365734 -
Won et al.
(2009)
Molecular reconstruction of mGluR5a-mediated endocannabinoid signaling cascade in single rat sympathetic neurons.
J Neurosci.
29:13603
PMID: 19864572 -
Ho and Randall
(2007)
Endothelium-dependent metabolism by endocannabinoid hydrolases and cyclooxygenases limits vasorelaxation to anandamide and 2-arachidonoylglycerol.
Exp Neurol.
150:641
PMID: 17245358 -
Nieri et al.
(2006)
Modulation of P-glycoprotein activity by cannabinoid molecules in HK-2 renal cells.
Br J Pharmacol.
148:682
PMID: 16715117 -
Okada et al.
(2005)
Biophysical properties of voltage-gated Na+ channels in frog parathyroid cells and their modulation by cannabinoids.
J Exp Biol.
208:4747
PMID: 16326956 -
Ronesi et al.
(2004)
Disruption of endocannabinoid release and striatal long-term depression by postsynaptic blockade of endocannabinoid membrane transport.
J Neurosci.
24:1673
PMID: 14973237 -
Williams et al.
(2003)
The FGF receptor uses the endocannabinoid signaling system to couple to an axonal growth response.
Proc Natl Acad Sci U S A.
160:481
PMID: 12578907
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Customer Reviews for 2-Arachidonylglycerol (1)
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Species: OtherAssay Type: In VivoUsed in a bacterial signaling assay to screen for potential sensors of 2-arachidonylglycerol. Very easy to work with, non-toxic to E. coli even at concentrations up to 1 mg/mL. Planning to reorder for some follow-up experiments. Only downside is having to store at -80C.
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