2-Palmitoylglycerol

Name: 2-Palmitoylglycerol
Brand: Tocris Bioscience
SKU: 2206

Tocris Bioscience, part of Bio-Techne | Catalog # 2206

COA / SDS

Endogenous lipid; enhances activity of 2-arachidonylglycerol (Cat. No. 1298)

Discontinued Product

2206 has been discontinued. View all Additional Cannabinoid-related Compounds products.

Key Product Details

Description:	Endogenous lipid; enhances activity of 2-arachidonylglycerol (Cat. No. 1298)
Alternative Names:	2-Palm-Gl, 2-PG
Chemical Name:	2-Hydroxy-1-(hydroxymethyl)ethyl hexadecanoic acid ester
Molecular Weight:	330.51

View Full Technical Details for 2-Palmitoylglycerol

Technical Data
Citations

Biological Activity for 2-Palmitoylglycerol

2-Palmitoylglycerol is a endogenous fatty acid glycerol ester that enhances activity of 2-arachidonylglycerol (Cat. No. 1298). Does not bind to CB₁ or CB₂ cannabinoid receptors, but potentiates the apparent binding of 2-AG and increases its ability to inhibit adenylyl cyclase. Enhances in vivo cannabinoid effects of 2-AG following combined administration with 2-linoleoylglycerol.

Technical Data for 2-Palmitoylglycerol

M. Wt	330.51
Formula	C₁₉H₃₈O₄
Storage	Store at -20°C
CAS Number	23470-00-0
PubChem ID	123409
InChi Key	BBNYCLAREVXOSG-UHFFFAOYSA-N
Smiles	OCC(CO)OC(CCCCCCCCCCCCCCC)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for 2-Palmitoylglycerol

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	ethanol	33.05	100
	DMSO	33.05	100

Preparing Stock Solutions for 2-Palmitoylglycerol

The following data is based on the product molecular weight 330.51.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.03 mL	15.13 mL	30.26 mL
5 mM	0.61 mL	3.03 mL	6.05 mL
10 mM	0.30 mL	1.51 mL	3.03 mL
50 mM	0.06 mL	0.30 mL	0.61 mL

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Reconstitution Calculator

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References for 2-Palmitoylglycerol

References are publications that support the biological activity of the product.

Gallily 2-Arachidonylglycerol, an endogenous cannabinoid, inhibits tumor necrosis factor-α production in murine macrophages, and in mice. Eur.J.Pharmacol. 2000 PMID: 11011050
Walker Endocannabinoids and related fatty acid derivatives in pain modulation. Chem.Phys.Lipids 2002 PMID: 12505698
Ben-Shabat An entourage effect: inactive endogenous fatty acid glycerol esters enhance 2-arachidonyl-glycerol cannabinoid activity. Eur.J.Pharmacol. 1998 PMID: 9721036