CID 16020046
Tocris Bioscience, part of Bio-Techne | Catalog # 4959
Selective GPR55 antagonist
Product Description
CID 16020046 is a selective GPR55 antagonist. Inhibits LPI-induced Ca2+ signaling (IC50 = 0.21 μM in HEK-GPR55 cells), ERK1/2 phosphorylation and GPR55-mediated transcription factor activation. Displays weak inhibition of acetylcholinesterase, μ-opioid receptor, KCNH2 and hERG. Decreases LPI-induced GPR55 internalization. Reduces experimental intestinal inflammation in mice.Product Specifications
Molecular Weight
425.44
Formula
C25H19N3O4
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
4-[4,6-Dihydro-4-(3-hydroxyphenyl)-3-(4-methylphenyl)-6-oxopyrrolo[3,4-c]pyrazol-5(1H)-yl]benzoic acid
CAS Number
834903-43-4
PubChem ID
16020046
InChI Key
VGUQVYZXABOXCX-UHFFFAOYSA-N
SMILES
O=C1N(C5=CC=C(C(O)=O)C=C5)C(C4=CC=CC(O)=C4)C2=C1NN=C2C3=CC=C(C)C=C3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 42.54 | 100 |
Preparing Stock Solutions
for CID 16020046
The following data is based on the product molecular weight 425.44
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.35 mL | 11.75 mL | 23.51 mL |
| 5 mM | 0.47 mL | 2.35 mL | 4.70 mL |
| 10 mM | 0.24 mL | 1.18 mL | 2.35 mL |
| 50 mM | 0.05 mL | 0.24 mL | 0.47 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Stančić The GPR55 antagonist CID16020046 protects against intestinal inflammation. Neurogastroenterol.Motil 2015 PMID: 26227635
- Kargl A selective antagonist reveals a potential role of G protein-coupled receptor 55 in platelet and endothelial cell function. J.Pharmacol.Exp.Ther. 2013 PMID: 23639801
Product Specific Notices for CID 16020046
For research use only
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