10 results for "DYRK Inhibitors" in Products
DYRK Inhibitors Products
Dual-specificity tyrosine phosphorylation-regulated kinases (DYRKs) are a family of serine/threonine kinases, consisting of DYRK1A, DYRK1B, DYRK2, DYRK3 and DYRK4. The DYRK family is closely related to the CMGC group of kinases (which contains CDKs, MAPKs, GSK and CLKs).
DYRKs are self-activated through auto phosphorylation of tyr-321 within the activation loop of their catalytic domain. Once activated, DYRKs phosphorylate serine and threonine residues on target proteins, which have been ...
Potent and selective DYRK inhibitor; orally bioavailable.
| Chemical Name: | (5Z)-2-[(2,6-Dichlorophenyl)amino]-5-(6-quinoxalinylmethylene)-4(5H)-thiazolone |
| Purity: | ≥95% (HPLC) |
Potent CK2A2 and CK2A1 inhibitor; also inhibits DYRK2
| Chemical Name: | N-[5-[[3-Cyano-7-(cyclopropylamino)pyrazolo[1,5-a]pyrimidin-5-yl]amino]-2-methylphenyl]propanamide |
| Purity: | ≥98% (HPLC) |
Potent DYRK1B inhibitor
| Chemical Name: | N-[2-Methoxy-4-(4-methyl-1-piperazinyl)phenyl]-4-(1-methyl-1H-pyrrolo[2,3-c]pyridin-3-yl)-2-pyrimidinamine |
| Purity: | ≥98% (HPLC) |
Potent and selective DYRK1A/B inhibitor
| Alternate Names: | R05454948 |
| Chemical Name: | N-[2-Chloro-5-[[[(3-chlorophenyl)methyl]amino]carbonyl]phenyl]-7,8-dihydro-2-methoxy-7-oxopyrido[2,3-d]pyrimidine-6-carboxamide |
| Purity: | ≥98% (HPLC) |
Potent and selective Dyrk1B kinase inhibitor
| Chemical Name: | 3-(2-Methyl-4-pyrimidinyl)-1-(phenylmethyl)-1H-pyrrolo[2,3-c]pyridine |
| Purity: | ≥98% (HPLC) |
Potent and selective DYRK1A inhibitor
| Chemical Name: | 7-Methoxy-1-methyl-9H-pyrido[3,4-b]indole |
| Purity: | ≥98% (HPLC) |
DYRK1A/B inhibitor
| Chemical Name: | (1Z)-1-(3-Ethyl-5-hydroxy-2(3H)-benzothiazolylidene)-2-propanone |
| Purity: | ≥98% (HPLC) |
Inhibitor of Clk and DYRK kinases
| Chemical Name: | 5-(1,3-Benzodioxol-5-yl)-N-[(3,5-dichlorophenyl)methyl]-4-pyrimidinamine hydrochloride |
| Purity: | ≥98% (HPLC) |
Potent and selective pan-CLK inhibitor; also inhibits DYRK1A/B
| Chemical Name: | 4-[1,1-Dimethyl-2-(4-methyl-1-piperazinyl)-2-oxoethyl]-N-[6-(4-pyridinyl)imidazo[1,2-a]pyridin-2-yl]benzamide |
| Purity: | ≥98% (HPLC) |
Potent LMTK3 inhibitor
| Chemical Name: | 6-(Pyridin-4-yl)-3-(3-(trifluoromethoxy)phenyl)imidazo[1,2-b]pyridazine |
| Purity: | ≥98% (HPLC) |
