TC-S 7004
Tocris Bioscience, part of Bio-Techne | Catalog # 5088
Potent and selective DYRK1A/B inhibitor
Key Product Details
Description
Potent and selective DYRK1A/B inhibitor
Alternative Names
R05454948
Product Description
TC-S 7004 is a potent and selective DYRK1A/B inhibitor (IC50 values are 22 and 68 nM respectively). Selective for DYRK1A/B over a panel of other kinases. Reduces accumulation of quiescent Panc1 pancreatic cancer cells in G0 under serum free conditions. Also induces DNA damage and apoptosis in quiescent Panc1 cells.Product Specifications
Molecular Weight
498.32
Formula
C23H17Cl2N5O4
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
N-[2-Chloro-5-[[[(3-chlorophenyl)methyl]amino]carbonyl]phenyl]-7,8-dihydro-2-methoxy-7-oxopyrido[2,3-d]pyrimidine-6-carboxamide
CAS Number
1386979-55-0
PubChem ID
57523919
InChI Key
CQKBSRPVZZLCJE-UHFFFAOYSA-N
SMILES
O=C(NC3=CC(C(NCC4=CC(Cl)=CC=C4)=O)=CC=C3Cl)C2=CC1=CN=C(OC)N=C1NC2=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 4.98 | 10 |
Preparing Stock Solutions
for TC-S 7004
The following data is based on the product molecular weight 498.32
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 20.07 mL | 100.34 mL | 200.67 mL |
| 0.5 mM | 4.01 mL | 20.07 mL | 40.13 mL |
| 1 mM | 2.01 mL | 10.03 mL | 20.07 mL |
| 5 mM | 0.40 mL | 2.01 mL | 4.01 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Anderson Pyrido[2,3-d]pyrimidines: discovery and preliminary SAR of a novel series of DYRK1B and DYRK1A inhibitors. Bioorg.Med.Chem.Lett. 2013 PMID: 24239188
- Ewton Inactivation of mirk/dyrk1b kinase targets quiescent pancreatic cancer cells. Mol.Cancer Ther. 2011 PMID: 21878655
Product Specific Notices for TC-S 7004
For research use only
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