C28

Product Description

C28 is a potent lemur tyrosine kinase 3 (LMTK3) inhibitor (IC₅₀ = 67 nM). Disrupts interaction of LMTK3 and HSP90 leading to degradation of LMTK3. Also inhibits CLK, DYRK1α, IRAK4 and HIPK2 (IC₅₀ values are 5 nM, 6 nM, 41 nM and 48 nM respectively). C28 inhibits growth and increases apoptosis in breast cancer cell lines (IC₅₀ = 6.5-14.77 μM) and reduces growth of tumors in xenograft and transgenic mouse models of breast cancer. Also reduces levels of ERα.

Licensing Information

Sold with kind permission of the Giamas lab, University of Sussex

Solubility

Preparing Stock Solutions for C28

The following data is based on the product molecular weight 356.31

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	5.61 mL	28.07 mL	56.13 mL
2.5 mM	1.12 mL	5.61 mL	11.23 mL
5 mM	0.56 mL	2.81 mL	5.61 mL
25 mM	0.11 mL	0.56 mL	1.12 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Ditsiou The structure-function relationship of oncogenic LMTK3. Sci.Adv. 2020 PMID: 33188023