GSK 626616
Tocris Bioscience, part of Bio-Techne | Catalog # 6638
Potent and selective DYRK inhibitor; orally bioavailable.
Key Product Details
Description
Potent and selective DYRK inhibitor; orally bioavailable.
Product Description
GSK 626616 is a potent and selective DYRK inhibitor (IC50 = 0.7 nM for DYRK3, similar potency for DYRK1 and 2). Exhibits ~20-fold selectivity over casein kinase 2 and negligible activity against a panel of 451 kinases screened. Enhances number of CFU-E stimulated by Epo from human marrow. Increases hemoglobin levels in anemic mice. Orally bioavailable.Product Specifications
Molecular Weight
401.27
Formula
C18H10Cl2N4OS
Storage
Store at +4°C
Purity
≥95% (HPLC)
Chemical Name
(5Z)-2-[(2,6-Dichlorophenyl)amino]-5-(6-quinoxalinylmethylene)-4(5H)-thiazolone
CAS Number
1025821-33-3
PubChem ID
135416229
InChI Key
RJPNRXFBYZVRIB-DHDCSXOGSA-N
SMILES
O=C(N=C(NC1=C(Cl)C=CC=C1Cl)S/2)C2=C\C3=CC=C(N=CC=N4)C4=C3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 40.13 | 100 |
Preparing Stock Solutions
for GSK 626616
The following data is based on the product molecular weight 401.27
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.49 mL | 12.46 mL | 24.92 mL |
| 5 mM | 0.50 mL | 2.49 mL | 4.98 mL |
| 10 mM | 0.25 mL | 1.25 mL | 2.49 mL |
| 50 mM | 0.05 mL | 0.25 mL | 0.50 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Wippich Dual specificity kinase DYRK3 couples stress granule condensation/dissolution to mTORC1 signaling. Cell 2013 PMID: 23415227
- Rai Kinase-controlled phase transition of membraneless organelles in mitosis. Nature 2018 PMID: 29973724
- Erickson-Miller GSK626616: A DYRK3 inhibitor as a potential new therapy for the treatment of anemia. Blood
Product Specific Notices for GSK 626616
For research use only
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