INDY

Name: INDY
Brand: Tocris Bioscience
SKU: 4997

Tocris Bioscience, part of Bio-Techne | Catalog # 4997

Citations (9)

COA / SDS

DYRK1A/B inhibitor

Key Product Details

Description:	DYRK1A/B inhibitor
Chemical Name:	(1Z)-1-(3-Ethyl-5-hydroxy-2(3H)-benzothiazolylidene)-2-propanone
Purity:	≥98% (HPLC)
Molecular Weight:	235.3

View Full Technical Details for INDY

Technical Data
Citations

Biological Activity for INDY

INDY is a DYRK1A/B inhibitor (IC₅₀ values are 0.23 and 0.24 μM, for DYRK1B and DYRKA respectively). Binds at the ATP-binding cleft of the enzyme. Reverses aberrant tau-phosphorylation and rescues repressed calcineurin/NFAT signaling. Impairs the self-renewal capacity of subventricular zone neural stem cells. Also available as a prodrug, proINDY (Cat. No. 4998).

Compound Libraries for INDY

INDY is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Stem Cell Library. Find out more about compound libraries available from Tocris.

Technical Data for INDY

M. Wt	235.3
Formula	C₁₂H₁₃NO₂S
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1169755-45-6
PubChem ID	69538603
InChi Key	GCSZJMUFYOAHFY-UHFFFAOYSA-N
Smiles	O=C(C)/C=C1SC2=CC=C(O)C=C2N\1CC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for INDY

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	23.53	100

Preparing Stock Solutions for INDY

The following data is based on the product molecular weight 235.3.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.25 mL	21.25 mL	42.50 mL
5 mM	0.85 mL	4.25 mL	8.50 mL
10 mM	0.42 mL	2.12 mL	4.25 mL
50 mM	0.08 mL	0.42 mL	0.85 mL

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References for INDY

References are publications that support the biological activity of the product.

Ogawa Development of a novel selective inhibitor of the Down syndrome-related kinase Dyrk1A. Nat.Commun. 2010 PMID: 20981014
Pozo Inhibition of DYRK1A destabilizes EGFR and reduces EGFR-dependent glioblastoma growth. J.Clin.Invest. 2013 PMID: 23635774