INDY
Tocris Bioscience, part of Bio-Techne | Catalog # 4997
DYRK1A/B inhibitor
Product Description
INDY is a DYRK1A/B inhibitor (IC50 values are 0.23 and 0.24 μM, for DYRK1B and DYRKA respectively). Binds at the ATP-binding cleft of the enzyme. Reverses aberrant tau-phosphorylation and rescues repressed calcineurin/NFAT signaling. Impairs the self-renewal capacity of subventricular zone neural stem cells. Also available as a prodrug, proINDY (Cat. No. 4998).Product Specifications
Molecular Weight
235.30
Formula
C12H13NO2S
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
(1Z)-1-(3-Ethyl-5-hydroxy-2(3H)-benzothiazolylidene)-2-propanone
CAS Number
1169755-45-6
PubChem ID
69538603
InChI Key
GCSZJMUFYOAHFY-UHFFFAOYSA-N
SMILES
O=C(C)/C=C1SC2=CC=C(O)C=C2N\1CC
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 23.53 | 100 |
Preparing Stock Solutions
for INDY
The following data is based on the product molecular weight 235.30
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.25 mL | 21.25 mL | 42.50 mL |
| 5 mM | 0.85 mL | 4.25 mL | 8.50 mL |
| 10 mM | 0.42 mL | 2.12 mL | 4.25 mL |
| 50 mM | 0.08 mL | 0.42 mL | 0.85 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Ogawa Development of a novel selective inhibitor of the Down syndrome-related kinase Dyrk1A. Nat.Commun. 2010 PMID: 20981014
- Pozo Inhibition of DYRK1A destabilizes EGFR and reduces EGFR-dependent glioblastoma growth. J.Clin.Invest. 2013 PMID: 23635774
Product Specific Notices for INDY
For research use only
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