AZ 191
Tocris Bioscience, part of Bio-Techne | Catalog # 5232
Potent DYRK1B inhibitor
Product Description
AZ 191 is a potent DYRK1B inhibitor (IC50 values are 17, 88 and 1890 nM for DYRK1B, DYRK1A and DYRK2 respectively). Inhibits DYRK1B-induced Gi phase cell cycle arrest in Panc-1 cells in vitro.External Portal Information
Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of AZ 191 is reviewed on the chemical probes website.Product Specifications
Molecular Weight
429.52
Formula
C24H27N7O
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
N-[2-Methoxy-4-(4-methyl-1-piperazinyl)phenyl]-4-(1-methyl-1H-pyrrolo[2,3-c]pyridin-3-yl)-2-pyrimidinamine
CAS Number
1594092-37-1
PubChem ID
72716071
InChI Key
ZYVXTMKTGDARKR-UHFFFAOYSA-N
SMILES
CN2C=C(C3=CC=NC(NC4=C(OC)C=C(N5CCN(C)CC5)C=C4)=N3)C1=CC=NC=C12
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 42.95 | 100 | |
| Ethanol | 8.59 | 20 |
Preparing Stock Solutions
for AZ 191
The following data is based on the product molecular weight 429.52
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.33 mL | 11.64 mL | 23.28 mL |
| 5 mM | 0.47 mL | 2.33 mL | 4.66 mL |
| 10 mM | 0.23 mL | 1.16 mL | 2.33 mL |
| 50 mM | 0.05 mL | 0.23 mL | 0.47 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Ashford A novel DYRK1B inhibitor AZ191 demonstrates that DYRK1B acts independently of GSK3 beta to phosphorylate cyclin D1 at Thr(286), not Thr(288). Biochem.J. 2014 PMID: 24134204
Product Specific Notices for AZ 191
For research use only
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