AZ Dyrk1B 33
Tocris Bioscience, part of Bio-Techne | Catalog # 5632
Potent and selective Dyrk1B kinase inhibitor
Key Product Details
Description
Potent and selective Dyrk1B kinase inhibitor
Product Description
AZ Dyrk1B 33 is a potent and selective ATP-competitive Dyrk1B kinase inhibitor (IC50 = 7 nM); displays distinct cellular effects when compared to DYRK1B knockdown through siRNA. Demonstrates cellular in vitro activity (IC50 = 194 nM). Exhibits better selectivity than AZ 191 (Cat. No 5232); displays no off-target effects against a panel of 124 kinases tested (no kinase was inhibited above 50% at 1 μM).Product Specifications
Molecular Weight
300.36
Formula
C19H16N4
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
3-(2-Methyl-4-pyrimidinyl)-1-(phenylmethyl)-1H-pyrrolo[2,3-c]pyridine
CAS Number
1679330-37-0
PubChem ID
118735338
InChI Key
CZCUSHJQJWKYTD-UHFFFAOYSA-N
SMILES
CC1=NC=CC(C2=CN(CC3=CC=CC=C3)C4=CN=CC=C42)=N1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| 1eq. HCl | 30.04 | 100 | |
| DMSO | 30.04 | 100 |
Preparing Stock Solutions
for AZ Dyrk1B 33
The following data is based on the product molecular weight 300.36
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.33 mL | 16.65 mL | 33.29 mL |
| 5 mM | 0.67 mL | 3.33 mL | 6.66 mL |
| 10 mM | 0.33 mL | 1.66 mL | 3.33 mL |
| 50 mM | 0.07 mL | 0.33 mL | 0.67 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Kettle Discovery and optimization of a novel series of Dyrk1B kinase inhibitors to explore a MEK resistance hypothesis. J.Med.Chem. 2015 PMID: 25738750
Product Specific Notices for AZ Dyrk1B 33
For research use only
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