
Cathepsin D Products
Cathepsin D is a lysosomal aspartic protease of the pepsin family. Human Cathepsin D is synthesized as a precursor protein, consisting of a signal peptide (residues 1 - 18), a propeptide (residues 19 - 64), and a mature chain (residues 65 - 412). The mature chain can be processed further to the light (residues 65 - 161) and heavy (residues 169 - 412) chains. It is expressed in most cells and over expressed in breast cancer cells. Cathepsin D is a major enzyme in protein degradation in lysosomes, and also involved in the presentation of antigenic peptides. Mice deficient in Cathepsin D have been shown to develop a progressive atrophy of the intestinal mucosa, a massive destruction of lymphoid organs, and a profound neuronal ceroid lipofucinosis, indicating that Cathepsin D is essential for proteolysis of proteins regulating cell growth and tissue homeostasis. Cathepsin D secreted from human prostate carcinoma cells are responsible for the generation of angiostatin, a potent endogenous inhibitor of angiogenesis.
18 results for "Cathepsin D" in Products
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Cathepsin D Products
Cathepsin D is a lysosomal aspartic protease of the pepsin family. Human Cathepsin D is synthesized as a precursor protein, consisting of a signal peptide (residues 1 - 18), a propeptide (residues 19 - 64), and a mature chain (residues 65 - 412). The mature chain can be processed further to the light (residues 65 - 161) and heavy (residues 169 - 412) chains. It is expressed in most cells and over expressed in breast cancer cells. Cathepsin D is a major enzyme in protein degradation in lysosomes, and also involved in the presentation of antigenic peptides. Mice deficient in Cathepsin D have been shown to develop a progressive atrophy of the intestinal mucosa, a massive destruction of lymphoid organs, and a profound neuronal ceroid lipofucinosis, indicating that Cathepsin D is essential for proteolysis of proteins regulating cell growth and tissue homeostasis. Cathepsin D secreted from human prostate carcinoma cells are responsible for the generation of angiostatin, a potent endogenous inhibitor of angiogenesis.
18 results for "Cathepsin D" in Products
Selective and high affinity cathepsin D inhibitor
Purity : | ≥95% (HPLC) |
Contains 4 membranes-each spotted in duplicate with 84 different cancer-related antibodies
Contains 4 membranes-each spotted in duplicate with 58 different obesity-related antibodies
Contains 4 membranes - each spotted in duplicate with 35 different protease antibodies
Contains 4 membranes-2 spotted in duplicate with antibodies against 35 different proteases and 2 spotted in duplicate with antibodies against 32 different protease inhibitors
Source : | NS0 |
Accession # : | P07339.1 |
Applications : | Enzyme Activity |
Contains 4 membranes - 2 spotted in duplicate with 62 different non-hematopoietic antibodies and 2 spotted in duplicate with 57 common antibodies
Clonality : | Polyclonal |
Host : | Goat IgG |
Applications : | Immunohistochemistry, Immunoprecipitation, Simple Western, Western Blot |
Clonality : | Polyclonal |
Host : | Goat IgG |
Applications : | Immunocytochemistry/Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blot |
Assay Range : | 62.5 - 4,000 pg/mL |
Applications : | ELISA |
Clonality : | Monoclonal |
Host : | Rat IgG2a Clone #204712 |
Applications : | Western Blot |
Clonality : | Monoclonal |
Host : | Mouse IgG1 Clone #185111 |
Applications : | Immunohistochemistry, Simple Western, Western Blot |
Clonality : | Polyclonal |
Host : | Goat IgG |
Applications : | Immunohistochemistry, Western Blot |
Clonality : | Polyclonal |
Host : | Goat IgG |
Applications : | Immunohistochemistry, Western Blot |
Clonality : | Monoclonal |
Host : | Mouse IgG2b Clone #984824 |
Applications : | Immunocytochemistry/Immunofluorescence |
Source : | NS0 |
Accession # : | Q3UCD9 |
Applications : | Enzyme Activity |
Clonality : | Monoclonal |
Host : | Mouse IgG2b Clone #984829 |
Applications : | ELISA |
Clonality : | Monoclonal |
Host : | Mouse IgG2b Clone #185109 |
Applications : | ELISA |