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Cathepsin D: Antibodies

Cathepsin D is a lysosomal aspartic protease of the pepsin family. Human Cathepsin D is synthesized as a precursor protein, consisting of a signal peptide (residues 1 - 18), a propeptide (residues 19 - 64), and a mature chain (residues 65 - 412). The mature chain can be processed further to the light (residues 65 - 161) and heavy (residues 169 - 412) chains. It is expressed in most cells and over expressed in breast cancer cells. Cathepsin D is a major enzyme in protein degradation in lysosomes, and also involved in the presentation of antigenic peptides. Mice deficient in Cathepsin D have been shown to develop a progressive atrophy of the intestinal mucosa, a massive destruction of lymphoid organs, and a profound neuronal ceroid lipofucinosis, indicating that Cathepsin D is essential for proteolysis of proteins regulating cell growth and tissue homeostasis. Cathepsin D secreted from human prostate carcinoma cells are responsible for the generation of angiostatin, a potent endogenous inhibitor of angiogenesis.

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68 results for "Cathepsin D Primary Antibodies" in Products

Cathepsin D: Antibodies

Cathepsin D is a lysosomal aspartic protease of the pepsin family. Human Cathepsin D is synthesized as a precursor protein, consisting of a signal peptide (residues 1 - 18), a propeptide (residues 19 - 64), and a mature chain (residues 65 - 412). The mature chain can be processed further to the light (residues 65 - 161) and heavy (residues 169 - 412) chains. It is expressed in most cells and over expressed in breast cancer cells. Cathepsin D is a major enzyme in protein degradation in lysosomes, and also involved in the presentation of antigenic peptides. Mice deficient in Cathepsin D have been shown to develop a progressive atrophy of the intestinal mucosa, a massive destruction of lymphoid organs, and a profound neuronal ceroid lipofucinosis, indicating that Cathepsin D is essential for proteolysis of proteins regulating cell growth and tissue homeostasis. Cathepsin D secreted from human prostate carcinoma cells are responsible for the generation of angiostatin, a potent endogenous inhibitor of angiogenesis.

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68 results for "Cathepsin D Primary Antibodies" in Products

ELISA, IHC, IP, WB
CyTOF-ready, ELISA, IHC, WB
IHC, WB

Recombinant Monoclonal Antibody

ELISA, IP, WB

Recombinant Monoclonal Antibody

WB, IHC, IP, ICC
WB, Simple Western, IHC, IP
WB, Simple Western, IHC
WB, IHC
WB, IHC
Catalog #: MAB10143
ELISA
Catalog #: MAB10142
ELISA
ELISA, IP, WB

Recombinant Monoclonal Antibody

IHC, WB

Recombinant Monoclonal Antibody

ELISA, IP, WB

Recombinant Monoclonal Antibody

ELISA, IP, WB

Recombinant Monoclonal Antibody

ELISA, IP, WB

Recombinant Monoclonal Antibody

IHC, WB

Recombinant Monoclonal Antibody

ELISA, IP, WB

Recombinant Monoclonal Antibody

IHC, WB

Recombinant Monoclonal Antibody

ELISA, IP, WB

Recombinant Monoclonal Antibody

ELISA, IP, WB

Recombinant Monoclonal Antibody

IHC, WB

Recombinant Monoclonal Antibody

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