Skip to main content

Fibroblast Growth Factor Superfamily

FGF Superfamily Ligands - Products by Molecule

FGF acidic/FGF-1 FGF basic/FGF-2 FGF-3 FGF-4 FGF-5 FGF-6
KGF/FGF-7 FGF-8 FGF-9 FGF-10 FGF-11 FGF-12
FGF-13 FGF-15 FGF-16 FGF-17 FGF-18 FGF-19
FGF-20 FGF-21 FGF-22 FGF-23 SUN 11602 (bFGF mimetic)  

FGF Superfamily Receptors - Products by Molecule

FGFR1 FGFR1 alpha FGFR1 beta FGFR2 FGFR2 alpha FGFR2 beta
FGFR3 FGFR4 FGFR1-4 FGFR5/FGFRL1 FGF Receptor Inhibitors Golgi Glycoprotein 1/GLG1

FGF Superfamily Regulators - Products by Molecule

alpha 2-Macroglobulin alpha 2-Macroglobulin-like 1/A2ML1 CNPY2 FGF-BP FGFBP2
FGFBP3 FRS2 Klotho Klotho beta LRIT3
Pentraxin3/TSG-14 Shisa-4 SPRY1 SPRY2 SPRY3

FGF Intracellular Signaling - Products by Molecule

Akt Akt1 Akt2 Akt3 Akt Inhibitors Calcineurin
Calcineurin A Calcineurin B Calmodulin CBL DEPTOR ERK1
ERK1/2 ERK2 ERK Inhibitors c-Fos FosB/G0S3 FoxO1/FKHR
FoxO3/FKHR FRA-1 FRS2 GBL GAB2 GRB2
GSK-3 alpha/beta GSK-3 beta GSK-3 Inhibitors IL-17 RD/SEF IP3 Receptor Agonists IP3 Receptor Inhibitors
Jak1 Jak2 JAK Inhibitors JNK JNK1 JNK1/JNK2
JNK2 JNK3 JNK Inhibitors c-Jun JunB JunD
MEK1 MEK1/2 MEK2 MEK Inhibitors MKP-1 MKP-3
NFATC1 NFATC2 NFATC3 NFAT Inhibitors p38 alpha p38 beta/MAPK11
p38 gamma p38 delta p38 Inhibitors p70 S6 Kinase p70 S6 Kinase Inhibitor PDK-1
PDK-1 Inhibitors PI 3-kinase p55 gamma PI 3-kinase p85 alpha PI 3-kinase p85 beta PI 3-kinase p110 beta PI 3-kinase p110 gamma
PI 3-kinase p110 delta PI 3-kinase Inhibitors PKC alpha PKC beta 1 PKC beta 2 PKC gamma
PKC epsilon PKC delta PKC iota/lambda PKC iota/lambda/zeta PKC theta PKC zeta
PLC-gamma 1 PLC-gamma 2 PRAS40 Rac1 Raf-1 Raf Kinase Inhibitors
Ras Ras GTPase Inhibitors Rheb Rho GTPase Inhibitors RPS6 RPTOR
SHB SHC1 SHP-2 SOS2 Src Src Family Kinase Inhibitors
STAT1 STAT3 STAT5a STAT5a/b STAT5b STAT Activators
STAT Inhibitors TOR mTOR Inhibitors TSC1 TSC2 Tyk2

R&D Systems Recombinant Human FGF basic/FGF-2 (146 aa) Displays Higher Activity than a Leading Competitor’s Recombinant Human FGF-2 (146 aa) Protein

Comparison of the bioactivity of R&D Systems Recombinant Human FGF basic/FGF-2 and a leading competitor’s FGF basic protein

R&D Systems Recombinant Human FGF basic/FGF-2 Displays Higher Activity than a Leading Competitor’s Recombinant Human FGF-2 Protein. The NR6R-3T3 mouse fibroblast cell line was treated with increasing concentrations of R&D Systems Recombinant Human FGF basic/FGF-2 (Catalog # 233-FB; orange line) or recombinant human FGF-2 from another company (blue line) and cell proliferation was assessed. The bioactivity of the R&D Systems FGF-2 protein was approximately 3-fold greater than the leading competitor’s FGF-2 protein.  

Immunostaining of FGF-9 in Human Placenta Using R&D Systems Goat Anti-Human FGF-9 Antigen Affinity-Purified Polyclonal Antibody

Detection of FGF-9 in human placenta using anti-human FGF-9 polyclonal antibody and counterstaining with hematoxylin

Detection of FGF-9 in Human Placenta. FGF-9 was detected in immersion-fixed, paraffin-embedded sections of human placenta using a Goat Anti-Human FGF-9 Antigen Affinity-purified Polyclonal Antibody (R&D Systems, Catalog # AF-273-NA). Tissue was stained with an Anti-Goat HRP-AEC Cell & Tissue Staining Kit and counterstained with hematoxylin (blue).

Cell Proliferation Induced by R&D Systems Recombinant Human KGF/FGF-7 and Neutralization by a Goat Anti-Human KGF/FGF-7 Antigen Affinity-Purified Polyclonal Antibody

KGF/FGF-7-induced cell proliferation of rhesus monkey epithelial cells and neutralization by a KGF/FGF-7 polyclonal antibody

KGF/FGF-7-induced Cell Proliferation is Neutralized Using a Goat Anti-Human KGF/FGF-7 Polyclonal Antibody. The 4MBr-5 rhesus monkey epithelial cell line was treated with increasing concentrations of Recombinant Human KGF/FGF-7 (R&D Systems, Catalog # 251-KG) and cell proliferation was assessed (orange line). The ED50 for this effect is 6-60 ng/mL. Proliferation stimulated by 125 ng/mL Recombinant Human KGF/FGF-7 was neutralized by treating the cells with increasing concentrations of a Goat Anti-Human KGF/FGF-7 Antigen Affinity-purified Polyclonal Antibody (R&D Systems, Catalog # AF-251-NA; blue line). The ND50 for this effect is typically 6-12 ug/mL.

Immunostaining of FGF-15 in Day E15 Mouse Embryo Using R&D Systems Sheep Anti-Mouse FGF-15 Antigen Affinity-Purified Polyclonal Antibody

Detection of FGF-15 in E15 mouse embryo using an anti-mouse FGF-15 polyclonal antibody and counterstaining with hematoxylin

Detection of FGF-15 in Mouse Embryo. FGF-15 was detected in immersion-fixed, frozen sections of day E15 mouse embryo using a Sheep Anti-Mouse FGF-15 Antigen Affinity-purified Polyclonal Antibody (R&D Systems, Catalog # AF6755). Tissue was stained using the Anti-Sheep HRP-DAB Cell & Tissue Staining Kit (R&D Systems, Catalog # CTS019; brown) and counterstained with hematoxylin (blue). Specific staining was localized to the processes of dorsal root ganglia neurons.

Cell Proliferation Induced by R&D Systems Recombinant Human FGF-21 and Neutralization by a Goat Anti-Human FGF-21 Monoclonal Antibody

FGF-21-induced cell proliferation of mouse pro-B cells transfected with FGF-RIIIc and neutralization by a FGF-21 antibody

FGF-21-induced Cell Proliferation is Neutralized Using a Goat Anti-Human FGF-21 Monoclonal Antibody. In the presence of Recombinant Mouse Klotho beta (R&D Systems, Catalog # 2619-KB), the BaF3 mouse pro-B cell line transfected with human FGF-RIIIc was treated with increasing concentrations of Recombinant Human FGF-21 (R&D Systems, Catalog # 2539-FG) and cell proliferation was assessed (orange line). The ED50 for this effect is 0.06-0.4 ug/mL. Under these conditions, proliferation stimulated by 500 ng/mL Recombinant Human FGF-21 was neutralized by treating the cells with increasing concentrations of a Goat Anti-Human FGF-21 Monoclonal Antibody (R&D Systems, Catalog # MAB25373; blue line). The ND50 for this effect is typically 0.5-3 ug/mL.

Featured Products for FGF Superfamily Research

image of a ProDot protein, a recombinant protein packaged into an easy-to-use ball, in a vial

ProDots™ Proteins for FGF-basic, FGF-3, FGF-7, FGF-10

Ensure optimal protein recovery and reduce media preparation time with our single-use vials of lyophilized ProDots Proteins. ProDots Proteins are R&D Systems™ proteins packaged into easy-to-use balls that can be rolled into your cell culture media. ProDots Proteins will simplify your media preparation by eliminating aliquoting and freeze/thaw cycles and will ensure 100% protein recovery.

Sandwich ELISA assay principle showing an antigen bound between specific capture and detection antibodies

Immunoassays for Detecting FGFs

From our complete ready-to-use Quantikine™ ELISA Kits to our more flexible DuoSet™ ELISA Development Systems, we offer a large selection of immunoassays for measuring different FGFs. Whatever target you’re interested in, you can count on our immunoassays to deliver accurate, reproducible data for every experimental sample that you test.

Proteome Profiler Teaser Solo

Proteome Profiler™ Human Phospho-Kinase Antibody Array

The Proteome Profiler Human Phospho-Kinase Antibody Array offers a simple and inexpensive method to simultaneously detect the phosphorylation of 37 different kinases in a single sample using chemiluminescence and standard Western blotting equipment. Utilize this multiplex membrane-based assay to explore the signaling pathways activated by different FGFs.

Featured FGF Superfamily-Related Resources

A thumbnail graphic of the periodic table of human developmental factors wall poster

Periodic Table of Human Developmental Factors Wall Poster

Learn about the different families of growth factors and morphogens that regulate human development with our Periodic Table of Human Developmental Factors wall poster. The poster includes information on the structures,  native molecular weights, and receptors for each protein and will serve as a great reference tool to keep in your lab or office space.

 

FGFs signal through FGF receptors and regulate processes essential for embryonic development and adult tissue homeostasis

Growth Factor Signaling Pathways

Growth factors activate intracellular signaling pathways that regulate a diverse range of biological processes, including development, cell proliferation, differentiation, motility, angiogenesis, and adult tissue homeostasis. Explore the signaling pathways that are activated by different growth factor families and the biological effects that they mediate using our interactive signaling pathways.

Stem Cells Research Teaser Solo

Products for Stem Cell Research

Minimize variability in your stem cell experiments and ensure high performance by using our stem cell culture reagents. From isolation and culture to verification, reprogramming, differentiation, and characterization, we have the products that you need for your stem cell work.