DL-AP5

Tocris Bioscience, part of Bio-Techne | Catalog # 0105

(3)

Citations (358)

COA / SDS

Potent and selective NMDA antagonist

Key Product Details

Description:	Potent and selective NMDA antagonist
Alternative Names:	DL-APV
Chemical Name:	DL-2-Amino-5-phosphonopentanoic acid
Purity:	≥98% (HPLC)
Molecular Weight:	197.13

View Full Technical Details for DL-AP5

Technical Data
Citations / Reviews (3)

Biological Activity for DL-AP5

DL-AP5 is a racemic mixture of the D- and L-isomers of AP5, a selective NMDA receptor antagonist that competes with glutamate binding and is commonly used to inhibit NMDA-dependent synaptic plasticity. D-AP5 (Cat. No. 0106) is the more active isomer and displays approximately 52-fold higher potency than the L-isomer, L-AP5 (Cat. No. 0107). In vitro D-AP5 reduces NMDA-induced depolarization of cortical neurons, with no effect on the response to L-Quisqualic acid (Cat. No. 0188) or Kainic acid (Cat. No. 0222). Following spinal injection of D-AP5, NMDA-response is rapidly reduced, with no effect seen on spontaneously active neurons.

D-isomer, L-isomer and sodium salt also available.

Technical Data for DL-AP5

M. Wt	197.13
Formula	C₅H₁₂NO₅P
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	76326-31-3
PubChem ID	1216
InChi Key	VOROEQBFPPIACJ-UHFFFAOYSA-N
Smiles	NC(C(O)=O)CCCP(O)(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for DL-AP5

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	1.97	10
	1eq. NaOH	19.71	100

Preparing Stock Solutions for DL-AP5

The following data is based on the product molecular weight 197.13.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	5.07 mL	25.36 mL	50.73 mL
5 mM	1.01 mL	5.07 mL	10.15 mL
10 mM	0.51 mL	2.54 mL	5.07 mL
50 mM	0.10 mL	0.51 mL	1.01 mL

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Reconstitution Calculator

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References for DL-AP5

References are publications that support the biological activity of the product.

Evans The effect of a series of ω-phosphonic-α-carboxylic amino acids on electrically evoked and amino acid induced responses in isolated spinal cord preparations. Br.J.Pharmacol. 1982 PMID: 7042024
Davies and Watkins Actions of D and L forms of 2-amino-5-phosphonovalerate and 2-amino-4-phosphonobutyrate in the cat spinal cord. Brain Res. 1982 PMID: 6145492