Key Product Details
Description: | Potent and selective NMDA antagonist |
Alternative Names: | DL-APV |
Chemical Name: | DL-2-Amino-5-phosphonopentanoic acid |
Purity: | ≥98% (HPLC) |
Molecular Weight: | 197.13 |
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Citations for DL-AP5 (89)
Citations are publications that use Bio-Techne products. Selected citations for DL-AP5 include:
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Hu et al.
(2019)
Endocannabinoid Signaling Mediates Local Dendritic Coordination between Excitatory and Inhibitory Synapses.
Cell Rep.
27:666
PMID: 30995465 -
Paul et al.
(2019)
Differential Regulation of Syngap1 Translation by FMRP Modulates eEF2 Mediated Response on NMDAR Activity.
Front Mol Neurosci.
12:97
PMID: 31143100 -
Romanos et al.
(2019)
Differences in glutamate uptake between cortical regions impact neuronal NMDA receptor activation.
Commun Biol.
2:127
PMID: 30963115 -
Yu et al.
(2019)
Prenatal selective serotonin reuptake inhibitor (SSRI) exposure induces working memory and social recognition deficits by disrupting inhibitory synaptic networks in male mice.
Mol Brain.
12:29
PMID: 30935412 -
Li et al.
(2019)
TMEM16B regulates anxiety-related behavior and GABAergic neuronal signaling in the central lateral amygdala.
Elife.
8
PMID: 31482844 -
Donovan et al.
(2019)
Lmx1b is required at multiple stages to build expansive serotonergic axon architectures.
Elife.
8
PMID: 31355748 -
Flossmann et al.
(2019)
Somatostatin Interneurons Promote Neuronal Synchrony in the Neonatal Hippocampus.
Cell Rep.
26:3173
PMID: 30893591 -
Kiritoshi and Neugebauer
(2018)
Pathway-specific alterations of cortico-amygdala transmission in an arthritis pain model.
ACS Chem Neurosci.
9:2252
PMID: 29630339 -
Ferlauto et al.
(2018)
Design and validation of a foldable and photovoltaic wide-field epiretinal prosthesis.
Nat Commun.
9:992
PMID: 29520006 -
Purkey et al.
(2018)
AKAP150 Palmitoylation Regulates Synaptic Incorporation of Ca2+-Permeable AMPA Receptors to Control LTP.
Cell Rep.
25:974
PMID: 30355502 -
Jalalvand et al.
(2018)
Cerebrospinal Fluid-Contacting Neurons Sense pH Changes and Motion in the Hypothalamus.
J Neurosci.
38:7713
PMID: 30037834 -
Copeland et al.
(2017)
Astrocytes modulate thalamic sensory processing via mGlu2 receptor activation.
Neuropharmacology.
121:100
PMID: 28416443 -
Pose-Utrilla et al.
(2017)
Excitotoxic inactivation of constitutive oxidative stress detoxification pathway in neurons can be rescued by PKD1.
Nat Commun.
8:2275
PMID: 29273751 -
Paul et al.
(2017)
Transcriptional Architecture of Synaptic Communication Delineates GABAergic Neuron Identity.
Cell.
171:522
PMID: 28942923 -
Morton et al.
(2016)
Electrophysiological Assessment of Serotonin and GABA Neuron Function in the Dorsal Raphe during the Third Trimester Equivalent Developmental Period in Mice(1,2,3).
Eneuro.
2
PMID: 26730407 -
Zhang et al.
(2016)
Loss of MeCP2 in cholinergic neurons causes part of RTT-like phenotypes via α7 receptor in hippocampus.
Cell Res.
26:728
PMID: 27103432 -
Kirwan et al.
(2015)
Development and function of human cerebral cortex neural networks from pluripotent stem cells in vitro.
Development.
142:3178
PMID: 26395144 -
Mellough et al.
(2015)
IGF-1 Signaling Plays an Important Role in the Formation of Three-Dimensional Laminated Neural Retina and Other Ocular Structures From Human Embryonic Stem Cells.
Stem Cells.
33:2416
PMID: 25827910 -
Gamir-Morralla et al.
(2015)
Development of a neuroprotective peptide that preserves survival pathways by preventing Kidins220/ARMS calpain processing induced by excitotoxicity.
Cell Death Dis.
6:e1939
PMID: 26492372 -
Vance et al.
(2015)
PAR1-activated astrocytes in the nucleus of the solitary tract stimulate adjacent neurons via NMDA receptors.
J Neurosci.
35:776
PMID: 25589770 -
Ferreira et al.
(2015)
GluN2B-Containing NMDA Receptors Regulate AMPA Receptor Traffic through Anchoring of the Synaptic Proteasome.
J Neurosci.
35:8462
PMID: 26041915 -
Wong et al.
(2015)
Rosiglitazone Suppresses In Vitro Seizures in Hippocampal Slice by Inhibiting Presynaptic Glutamate Release in a Model of Temporal Lobe Epilepsy.
PLoS One.
10:e0144806
PMID: 26659605 -
Araki et al.
(2015)
Rapid dispersion of SynGAP from synaptic spines triggers AMPA receptor insertion and spine enlargement during LTP.
Neuron.
85:173
PMID: 25569349 -
Liu et al.
(2015)
Muscarinic receptors modulate dendrodendritic inhibitory synapses to sculpt glomerular output.
J Neurosci.
35:5680
PMID: 25855181 -
Sarro et al.
(2015)
Cortical Synaptic Inhibition Declines during Auditory Learning.
J Neurosci.
35:6318
PMID: 25904785 -
Bajo et al.
(2015)
IL-1 interacts with ethanol effects on GABAergic transmission in the mouse central amygdala.
Front Pharmacol.
6:49
PMID: 25852553 -
Hipólito et al.
(2015)
In vivo activation of the SK channel in the spinal cord reduces the NMDA receptor antagonist dose needed to produce antinociception in an inflammatory pain model.
Pain.
156:849
PMID: 25734988 -
Halff et al.
(2014)
A novel mechanism for nicotinic potentiation of glutamatergic synapses.
J Neurosci.
34:2051
PMID: 24501347 -
Tamura et al.
(2014)
Both neurons and astrocytes exhibited tetrodotoxin-resistant metabotropic glutamate receptor-dependent spontaneous slow Ca2+ oscillations in striatum.
PLoS One.
9:e85351
PMID: 24454845 -
Wilcox et al.
(2014)
Repeated binge-like ethanol drinking alters ethanol drinking patterns and depresses striatal GABAergic transmission.
Neuropsychopharmacology.
39:579
PMID: 23995582 -
Röther et al.
(2014)
Dynamic properties of the alkaline vesicle population at hippocampal synapses.
PLoS One.
9:e102723
PMID: 25079223 -
Diaz et al.
(2014)
Moderate Alcohol Exposure during the Rat Equivalent to the Third Trimester of Human Pregnancy Alters Regulation of GABAA Receptor-Mediated Synaptic Transmission by DA in the Basolateral Amygdala.
Front Pediatr.
2:46
PMID: 24904907 -
Lee et al.
(2014)
Synapse elimination and learning rules co-regulated by MHC class I H2-Db.
Nature.
509:195
PMID: 24695230 -
Purohit et al.
(2014)
The Ca2+ sensor protein swiprosin-1/EFhd2 is present in neurites and involved in kinesin-mediated transport in neurons.
PLoS One.
9:e103976
PMID: 25133820 -
Rovó et al.
(2014)
Phasic, nonsynaptic GABA-A receptor-mediated inhibition entrains thalamocortical oscillations.
J Neurosci.
34:7137
PMID: 24849349 -
Granger and Nicoll
(2014)
LTD expression is independent of glutamate receptor subtype.
Front Synaptic Neurosci.
6:15
PMID: 25071549 -
Kallupi et al.
(2014)
Nociceptin/orphanin FQ decreases glutamate transmission and blocks ethanol-induced effects in the central amygdala of naive and ethanol-dependent rats.
Neuropsychopharmacology.
39:1081
PMID: 24169802 -
Tyagarajan et al.
(2013)
Extracellular signal-regulated kinase and glycogen synthase kinase 3β regulate gephyrin postsynaptic aggregation and GABAergic synaptic function in a calpain-dependent mechanism.
J Biol Chem.
288:9634
PMID: 23408424 -
Thayer et al.
(2013)
Increased neuronal activity fragments the Golgi complex.
Proc Natl Acad Sci U S A.
110:1482
PMID: 23297202 -
Rehak et al.
(2013)
Low voltage activation of KCa1.1 current by Cav3-KCa1.1 complexes.
PLoS One.
8:e61844
PMID: 23626738 -
Berlinguer-Palmini et al.
(2013)
GPR35 activation reduces Ca2+ transients and contributes to the kynurenic acid-dependent reduction of synaptic activity at CA3-CA1 synapses.
PLoS One.
8:e82180
PMID: 24312407 -
Gkogkas et al.
(2013)
Autism-related deficits via dysregulated eIF4E-dependent translational control.
Nature.
493:371
PMID: 23172145 -
Vivar et al.
(2012)
Mixed electrical-chemical transmission between hippocampal mossy fibers and pyramidal cells.
Eur J Neurosci.
35:76
PMID: 22151275 -
Shih et al.
(2012)
Spinal cord NMDA receptor-mediated activation of mammalian target of rapamycin is required for the development and maintenance of bone cancer-induced pain hypersensitivities in rats.
J Pain.
13:338
PMID: 22341316 -
Seese et al.
(2012)
LTP induction translocates cortactin at distant synapses in wild-type but not Fmr1 knock-out mice.
J Neurosci.
32:7403
PMID: 22623686 -
McKeown et al.
(2012)
Disruption of Eaat2b, a glutamate transporter, results in abnormal motor behaviors in developing zebrafish.
Dev Biol.
362:162
PMID: 22094018 -
Chacón et al.
(2012)
Focal adhesion kinase regulates actin nucleation and neuronal filopodia formation during axonal growth.
Development.
139:3200
PMID: 22872087 -
Mulholland et al.
(2012)
Chronic ethanol up-regulates the synaptic expression of the nuclear translational regulatory protein AIDA-1 in primary hippocampal neurons.
Alcohol.
46:569
PMID: 22703994 -
Lau and Murthy
(2012)
Activity-dependent regulation of inhibition via GAD67.
J Neurosci.
32:8521
PMID: 22723692 -
Patyal et al.
(2012)
Local hypocretin-1 modulates terminal DA concentration in the nucleus accumbens shell.
Front Behav Neurosci.
6:82
PMID: 23226119 -
Peterfi et al.
(2012)
Endocannabinoid-mediated long-term depression of afferent excitatory synapses in hippocampal pyramidal cells and GABAergic interneurons.
J Neurosci.
32:14448
PMID: 23055515 -
Lee et al.
(2012)
Actin-dependent rapid recruitment of reluctant synaptic vesicles into a fast-releasing vesicle pool.
Proc Natl Acad Sci U S A.
109:E765
PMID: 22393020 -
Klug et al.
(2012)
Genetic inhibition of CaMKII in dorsal striatal medium spiny neurons reduces functional excitatory synapses and enhances intrinsic excitability.
PLoS One.
7:e45323
PMID: 23028932 -
Reali et al.
(2011)
GABAergic signalling in a neurogenic niche of the turtle spinal cord.
J Physiol.
589:5633
PMID: 21911613 -
Yang et al.
(2011)
SynGAP moves out of the core of the postsynaptic density upon depolarization.
Neuroscience.
192:132
PMID: 21736925 -
Tang et al.
(2011)
Neto1 is an auxiliary subunit of native synaptic kainate receptors.
J Neurosci.
31:10009
PMID: 21734292 -
Zhong et al.
(2011)
Neurogranin phosphorylation fine-tunes long-term potentiation.
Eur J Neurosci.
33:244
PMID: 21198977 -
Wang et al.
(2011)
Functional NMDA receptors at axonal growth cones of young hippocampal neurons.
J Neurosci.
31:9289
PMID: 21697378 -
Zhao et al.
(2011)
Homeostatic synaptic plasticity through changes in presynaptic calcium influx.
J Neurosci.
31:7492
PMID: 21593333 -
Sun et al.
(2011)
Specificity and actions of an arylaspartate inhibitor of glutamate transport at the Schaffer collateral-CA1 pyramidal cell synapse.
PLoS One.
6:e23765
PMID: 21887314 -
Stein and Chetkovich
(2010)
Regulation of stargazin synaptic trafficking by C-terminal PDZ ligand phosphorylation in bidirectional synaptic plasticity.
J Neurochem.
113:42
PMID: 19968761 -
Torborg et al.
(2010)
Control of CA3 output by feedforward inhibition despite developmental changes in the excitation-inhibition balance.
J Neurosci.
30:15628
PMID: 21084618 -
Zheng et al.
(2010)
SAP102 is a highly mobile MAGUK in spines.
J Neurosci.
30:4757
PMID: 20357126 -
Noh et al.
(2010)
Glutamate co-release at GABA/glycinergic synapses is crucial for the refinement of an inhibitory map.
Nat Neurosci.
13:232
PMID: 20081852 -
Rio et al.
(2010)
M3 muscarinic acetylcholine receptor expression confers differential cholinergic modulation to neurochemically distinct hippocampal basket cell subtypes.
J Neurosci.
30:6011
PMID: 20427660 -
Han et al.
(2010)
Reduction in synaptic GABA release contributes to target-selective elevation of PVN neuronal activity in rats with myocardial infarction.
Am J Physiol Regul Integr Comp Physiol.
299:R129
PMID: 20164200 -
Zang et al.
(2009)
A mouse model of the human Fragile X syndrome I304N mutation.
PLoS Genet.
5:e1000758
PMID: 20011099 -
Sipilä et al.
(2009)
Compensatory enhancement of intrinsic spiking upon NKCC1 disruption in neonatal hippocampus.
J Neurosci.
29:6982
PMID: 19474325 -
Costa et al.
(2008)
Electrophysiology and pharmacology of striatal neuronal dysfunction induced by mitochondrial complex I inhibition.
J Neurosci.
28:8040
PMID: 18685029 -
Baltan et al.
(2008)
White matter vulnerability to ischemic injury increases with age because of enhanced excitotoxicity.
J Neurosci.
28:1479
PMID: 18256269 -
Kash et al.
(2008)
DA enhances fast excitatory synaptic transmission in the extended amygdala by a CRF-R1-dependent process.
J Neurosci.
28:13856
PMID: 19091975 -
Manning et al.
(2008)
NMDA receptor blockade with Mem. attenuates white matter injury in a rat model of periventricular leukomalacia.
J Neurosci.
28:6670
PMID: 18579741 -
Maher and Westbrook
(2008)
Co-transmission of DA and GABA in periglomerular cells.
J Neurophysiol.
99:1559
PMID: 18216231 -
Brill and Huguenard
(2008)
Sequential changes in AMPA receptor targeting in the developing neocortical excitatory circuit.
J Neurosci.
28:13918
PMID: 19091980 -
Power and Sah
(2008)
Competition between calcium-activated K+ channels determines cholinergic action on firing properties of basolateral amygdala projection neurons.
J Neurosci.
28:3209
PMID: 18354024 -
Woo et al.
(2007)
Neuregulin-1 enhances depolarization-induced GABA release.
Neuron.
54:599
PMID: 17521572 -
Young and Sun
(2007)
Long-term modifications in the strength of excitatory associative inputs in the piriform cortex.
Chem Senses.
32:783
PMID: 17634388 -
Nosyreva and Huber
(2006)
Metabotropic receptor-dependent long-term depression persists in the absence of protein synthesis in the mouse model of fragile X syndrome.
J Neurophysiol.
95:3291
PMID: 16452252 -
Ince-Dunn et al.
(2006)
Regulation of thalamocortical patterning and synaptic maturation by NeuroD2.
Neuron.
49:683
PMID: 16504944 -
Kopp et al.
(2006)
Insufficient sleep reversibly alters bidirectional synaptic plasticity and NMDA receptor function.
J Neurosci.
26:12456
PMID: 17135407 -
Gómez-Lira et al.
(2005)
Programmed and induced phenotype of the hippocampal granule cells.
J Neurosci.
25:6939
PMID: 16049169 -
Bender et al.
(2005)
Synchronized network activity in developing rat hippocampus involves regional hyperpolarization-activated cyclic nucleotide-gated (HCN) channel function.
Eur J Neurosci.
22:2669
PMID: 16307610 -
Lenz and Avruch
(2005)
Glutamatergic regulation of the p70S6 kinase in primary mouse neurons.
J Biol Chem.
280:38121
PMID: 16183639 -
Kinney
(2005)
GAT-3 transporters regulate inhibition in the neocortex.
J Neurophysiol.
94:4533
PMID: 16135550 -
Melyan et al.
(2004)
Metabotropic regulation of intrinsic excitability by synaptic activation of kainate receptors.
J Neurosci.
24:4530
PMID: 15140923 -
Ronesi et al.
(2004)
Disruption of endocannabinoid release and striatal long-term depression by postsynaptic blockade of endocannabinoid membrane transport.
J Neurosci.
24:1673
PMID: 14973237 -
Selcher et al.
(2003)
A role for ERK MAP kinase in physiologic temporal integration in hippocampal area CA1.
Learn Mem.
10:26
PMID: 12551961 -
Yamaguchi et al.
(2002)
A GDP/GTP exchange protein for the Rab3 small G protein family up-regulates a postdocking step of synaptic exocytosis in central synapses.
Proc Natl Acad Sci U S A.
99:14536
PMID: 12388783 -
Bureau et al.
(2000)
Kainate receptor-mediated synaptic currents in cerebellar Golgi cells are not shaped by diffusion of glutamate.
Proc Natl Acad Sci U S A.
97:6838
PMID: 10841579
There are no citations that match your criteria.
Customer Reviews for DL-AP5 (2)
Customer Images
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Species: MouseAssay Type: Ex VivoBlocks NMDA currents as expected
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Species: RatAssay Type: In VitroCell Line/Tissue: amygdala neurons50uM used to antagonize NMDA receptors to isolate AMPA current.5 minutes perfusion at ~1.5ml/min was sufficient for the full effect.
There are no reviews that match your criteria.