L-AP5
Tocris Bioscience, part of Bio-Techne | Catalog # 0107
Potent and selective NMDA antagonist; less active form of DL-AP5
Key Product Details
Description
Potent and selective NMDA antagonist; less active form of DL-AP5
Product Description
L-AP5 is an NMDA antagonist and an agonist at quisqualate-sensitized AP6 site, where it is more potent than the isomer D-AP5. L-AP5 is more potent than D-AP5 at depressing synaptic responses at amino acid-induced and synaptic excitation of cat spinal neurons.D-isomer, DL mixture and sodium salt also available.
Product Specifications
Molecular Weight
197.13
Formula
C5H12NO5P
Storage
Store at RT
Purity
≥98% (HPLC)
Chemical Name
L-(+)-2-Amino-5-phosphonopentanoic acid
CAS Number
79055-67-7
PubChem ID
1617110
InChI Key
VOROEQBFPPIACJ-BYPYZUCNSA-N
SMILES
[H][C@@](CCCP(O)(O)=O)(N)C(O)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 100 |
Preparing Stock Solutions
for L-AP5
The following data is based on the product molecular weight 197.13
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 5.07 mL | 25.36 mL | 50.73 mL |
| 5 mM | 1.01 mL | 5.07 mL | 10.15 mL |
| 10 mM | 0.51 mL | 2.54 mL | 5.07 mL |
| 50 mM | 0.10 mL | 0.51 mL | 1.01 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Evans The effect of a series of ω-phosphonic-α-carboxylic amino acids on electrically evoked and amino acid induced responses in isolated spinal cord preparations. Br.J.Pharmacol. 1982 PMID: 7042024
- Schulte Utilization of the resolved L-isomer fo 2-amino-6-phosphonohexanoic acid (L-AP6) as a selective agonist for a quisqualate-sensitized site in hippocampal CA1 pyramidal neurons. Brain Res. 1994 PMID: 7953634
- Davies and Watkins Actions of D and L forms of 2-amino-5-phosphonovalerate and 2-amino-4-phosphonobutyrate in the cat spinal cord. Brain Res. 1982 PMID: 6145492
Product Specific Notices for L-AP5
For research use only
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