DL-AP5 Sodium salt

Name: DL-AP5 Sodium salt
Brand: Tocris Bioscience
SKU: 3693
Rating: 5 (2 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 3693

(2)

Citations (85)

COA / SDS

Potent and selective NMDA antagonist; sodium salt of DL-AP5

Key Product Details

Description:	Potent and selective NMDA antagonist; sodium salt of DL-AP5
Chemical Name:	DL-2-Amino-5-phosphonopentanoic acid sodium salt
Purity:	≥98% (HPLC)
Molecular Weight:	219.11

View Full Technical Details for DL-AP5 Sodium salt

Technical Data
Citations / Reviews (2)

Biological Activity for DL-AP5 Sodium salt

DL-AP5 Sodium salt is the sodium salt of DL-AP5 (Cat. No. 0105) and a racemic mixture of the D- and L-isomers of AP5, a selective NMDA receptor antagonist that competes with glutamate binding and is commonly used to inhibit NMDA-dependent synaptic plasticity. D-AP5 (Cat. No. 0106) is the more active isomer and displays approximately 52-fold higher potency than the L-isomer, L-AP5 (Cat. No. 0107). In vitro D-AP5 reduces NMDA-induced depolarization of cortical neurons, with no effect on the response to L-Quisqualic acid (Cat. No. 0188) or Kainic acid (Cat. No. 0222). Following spinal injection of D-AP5, NMDA-response is rapidly reduced, with no effect seen on spontaneously active neurons.

DL mixture, D-isomer and L-isomer also available.

Technical Data for DL-AP5 Sodium salt

M. Wt	219.11
Formula	C₅H₁₁NNaO₅P
Storage	Desiccate at RT
Purity	≥98% (HPLC)
CAS Number	1303993-72-7
PubChem ID	52974251
InChi Key	KWRCYAPNGUCHOE-UHFFFAOYSA-M
Smiles	[Na+].NC(CCCP(O)([O-])=O)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for DL-AP5 Sodium salt

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	21.91	100

Preparing Stock Solutions for DL-AP5 Sodium salt

The following data is based on the product molecular weight 219.11.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.56 mL	22.82 mL	45.64 mL
5 mM	0.91 mL	4.56 mL	9.13 mL
10 mM	0.46 mL	2.28 mL	4.56 mL
50 mM	0.09 mL	0.46 mL	0.91 mL

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Reconstitution Calculator

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References for DL-AP5 Sodium salt

References are publications that support the biological activity of the product.

Davies and Watkins Actions of D and L forms of 2-amino-5-phosphonovalerate and 2-amino-4-phosphonobutyrate in the cat spinal cord. Brain Res. 1982 PMID: 6145492
Evans The effect of a series of ω-phosphonic-α-carboxylic amino acids on electrically evoked and amino acid induced responses in isolated spinal cord preparations. Br.J.Pharmacol. 1982 PMID: 7042024