Key Product Details
Description: | Potent and selective NMDA receptor antagonist; more active form of DL-AP5 |
Alternative Names: | 2-APV, D-APV, D-2-amino-5-phosphonovalerate |
Chemical Name: | D-(-)-2-Amino-5-phosphonopentanoic acid |
Purity: | ≥99% (HPLC) |
Molecular Weight: | 197.13 |
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Citations for D-AP5 (372)
Citations are publications that use Bio-Techne products. Selected citations for D-AP5 include:
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Sabater et al.
(2021)
Voltage-gated potassium channels ensure action potential shape fidelity in distal axons.
J Neurosci.
41:5372
PMID: 34001627 -
Kramer et al.
(2020)
Axonal mechanisms mediating γ-aminobutyric acid receptor type A (GABA-A) inhibition of striatal dopamine release.
ELife.
9
PMID: 32870779 -
Evans et al.
(2020)
Functional Dissection of Basal Ganglia Inhibitory Inputs onto Substantia Nigra Dopaminergic Neurons.
Cell Rep.
32
PMID: 32937133 -
Dorst et al.
(2020)
Polysynaptic inhibition between striatal cholinergic interneurons shapes their network activity patterns in a dopamine-dependent manner.
Nat Comms.
11:5113
PMID: 33037215 -
He et al.
(2020)
Nucleus Accumbens Tac1-Expressing Neurons Mediate Stress-Induced Anhedonia-like Behavior in Mice.
Cell Rep.
33
PMID: 33147466 -
Battefeld et al.
(2019)
High-Frequency Microdomain Ca2+ Transients and Waves during Early Myelin Internode Remodeling.
Cell Rep.
26:182
PMID: 30605675 -
Spoljaric et al.
(2019)
KCC2-Mediated Cl- Extrusion Modulates Spontaneous Hippocampal Network Events in Perinatal Rats and Mice.
Cell Rep.
26:1073
PMID: 30699338 -
Nguyen et al.
(2019)
Simultaneous voltage and calcium imaging and optogenetic stimulation with high sensitivity and a wide field of view.
Biomed Opt Express.
10:789
PMID: 30800515 -
Woo et al.
(2019)
Pharmacological Dissection of Intrinsic Optical Signal Reveals a Functional Coupling between Synaptic Activity and Astrocytic Volume Transient.
Exp Neurobiol.
28:30
PMID: 30853822 -
Bülow et al.
(2019)
Homeostatic Intrinsic Plasticity Is Functionally Altered in Fmr1 KO Cortical Neurons.
Cell Rep.
26:1378
PMID: 30726724 -
Zhang et al.
(2019)
Role of intraganglionic transmission in the trigeminovascular pathway.
Mol Pain.
15:1744806919836570
PMID: 30784351 -
Nam et al.
(2019)
Activation of Astrocytic μ-Opioid Receptor Causes Conditioned Place Preference.
Cell Rep.
28:1154
PMID: 31365861 -
Octeau et al.
(2019)
Transient, Consequential Increases in Extracellular Potassium Ions Accompany Channelrhodopsin2 Excitation.
Cell Rep.
27:2249
PMID: 31116972 -
Pagani et al.
(2019)
How Gastrin-Releasing Peptide Opens the Spinal Gate for Itch.
Neuron.
2019;
PMID: 31103358 -
Meijer et al.
(2019)
A Single-Cell Model for Synaptic Transmission and Plasticity in Human iPSC-Derived Neurons.
Cell Rep.
27:2199
PMID: 31091456 -
Nasrallah et al.
(2019)
Routing Hippocampal Information Flow through Parvalbumin Interneuron Plasticity in Area CA2.
Cell Rep.
27:86
PMID: 30943417 -
Falcucci et al.
(2019)
Novel positive allosteric modulators of glutamate transport have neuroprotective properties in an in vitro excitotoxic model.
ACS Chem Neurosci.
10:3437
PMID: 31257852 -
Duman et al.
(2019)
The adhesion-GPCR BAI1 shapes dendritic arbors via Bcr-mediated RhoA activation causing late growth arrest.
Elife.
8
PMID: 31461398 -
Chiu et al.
(2019)
NMDAR-Activated PP1 Dephosphorylates GluN2B to Modulate NMDAR Synaptic Content.
Cell Rep.
28:332
PMID: 31291571 -
Wagner et al.
(2019)
Myosin VI Drives Clathrin-Mediated AMPA Receptor Endocytosis to Facilitate Cerebellar Long-Term Depression.
Cell Rep.
28:11
PMID: 31269433 -
Ji et al.
(2019)
Kibra Modulates Learning and Memory via Binding to Dendrin.
Cell Rep.
26:2064
PMID: 30784589 -
Chou et al.
(2018)
(2R,6R)-hydroxynorKA rescues chronic stress-induced depression-like behavior through its actions in the midbrain periaqueductal gray.
Neuropharmacology.
139:1
PMID: 29953886 -
González-Rueda et al.
(2018)
Activity-Dependent Downscaling of Subthreshold Synaptic Inputs during Slow-Wave-Sleep-like Activity In Vivo.
Neuron.
97:1244
PMID: 29503184 -
Chuhma et al.
(2018)
DA neuron glutamate cotransmission evokes a delayed excitation in lateral dorsal striatal cholinergic interneurons.
Elife.
7
PMID: 30295607 -
Yasuda et al.
(2018)
Drebrin Isoforms Critically Regulate NMDAR- and mGluR-Dependent LTD Induction.
Front Cell Neurosci.
12:330
PMID: 30349460 -
Smith et al.
(2018)
Calcium Channel CaV2.3 Subunits Regulate Hepatic Glucose Production by Modulating Leptin-Induced Excitation of Arcuate Pro-opiomelanocortin Neurons.
Cell Rep.
25:278
PMID: 30304668 -
Dong et al.
(2018)
CAST/ELKS Proteins Control Voltage-Gated Ca2+ Channel Density and Synaptic Release Probability at a Mammalian Central Synapse.
Cell Rep.
24:284
PMID: 29996090 -
Fan et al.
(2018)
All-optical synaptic electrophysiology probes mechanism of ketamine-induced disinhibition.
Nat Methods.
15:823
PMID: 30275587 -
Cai and Ford
(2018)
DA Cells Differentially Regulate Striatal Cholinergic Transmission across Regions through Corelease of DA and Glutamate.
Cell Rep.
25:3148
PMID: 30540946 -
Leroy et al.
(2018)
A circuit from hippocampal CA2 to lateral septum disinhibits social aggression.
Nature.
564:213
PMID: 30518859 -
Glasgow et al.
(2018)
Activity-Dependent Netrin-1 Secretion Drives Synaptic Insertion of GluA1-Containing AMPA Receptors in the Hippocampus.
Cell Rep.
25:168
PMID: 30282026 -
Beas et al.
(2018)
The locus coeruleus drives disinhibition in the midline thalamus via a dopaminergic mechanism.
Nat Neurosci.
21:963
PMID: 29915192 -
Adamsky et al.
(2018)
Astrocytic Activation Generates De Novo Neuronal Potentiation and Memory Enhancement.
Cell.
174:59
PMID: 29804835 -
Filipello et al.
(2018)
The Microglial Innate Immune Receptor TREM2 Is Required for Synapse Elimination and Normal Brain Connectivity.
Immunity.
48:979
PMID: 29752066 -
Assous
(2017)
Differential processing of thalamic information via distinct striatal interneuron circuits.
Nat Commun.
8:15860
PMID: 28604688 -
Guo
(2017)
DA D4 receptor activation restores CA1 LTP in hippocampal slices from aged mice.
Aging Cell.
16(6):1323
PMID: 28975698 -
Kashima and Grueter
(2017)
Toll-like receptor 4 deficiency alters nucleus accumbens synaptic physiology and drug reward behavior.
Proc Natl Acad Sci U S A..
114(3):8865
PMID: 28760987 -
Leyrer-Jackson
(2017)
Subtype-specific effects of DArgic D2 receptor activation on synaptic trains in layer V pyramidal neurons in the mouse prefrontal cortex.
Physiol Rep.
5(22):e13499
PMID: 29150590 -
Zhu et al.
(2017)
Impairments of spatial memory in an Alzheimer's disease model via degeneration of hippocampal cholinergic synapses.
Nat Commun.
8:1676
PMID: 29162816 -
Medrihan et al.
(2017)
Initiation of Behavioral Response to Antidepressants by Cholecystokinin Neurons of the Dentate Gyrus.
Neuron.
95:564
PMID: 28735749 -
Sun et al.
(2017)
Proximodistal Heterogeneity of Hippocampal CA3 Pyramidal Neuron Intrinsic Properties, Connectivity, and Reactivation during Memory Recall.
Neuron.
95:656
PMID: 28772124 -
Leroy et al.
(2017)
Input-Timing-Dependent Plasticity in the Hippocampal CA2 Region and Its Potential Role in Social Memory.
Neuron.
95:1089
PMID: 28823730 -
Pirbhoy et al.
(2017)
Synaptically driven phosphorylation of ribosomal protein S6 is differentially regulated at active synapses versus dendrites and cell bodies by MAPK and PI3K/mTOR signaling pathways.
Learn Mem.
24:341
PMID: 28716954 -
Liu et al.
(2017)
IGF1-Dependent Synaptic Plasticity of Mitral Cells in Olfactory Memory during Social Learning.
Neuron.
95:106
PMID: 28683263 -
Kim and Cho
(2017)
Encoding of Discriminative Fear Memory by Input-Specific LTP in the Amygdala.
Neuron.
95:1129
PMID: 28823727 -
Li et al.
(2017)
A Critical Role of Presynaptic Cadherin/Catenin/p140Cap Complexes in Stabilizing Spines and Functional Synapses in the Neocortex.
Neuron.
94:1155
PMID: 28641114 -
Park et al.
(2016)
Calcium-Permeable AMPA Receptors Mediate the Induction of the Protein Kinase A-Dependent Component of Long-Term Potentiation in the Hippocampus.
J Neurosci.
36:622
PMID: 26758849 -
Dennis et al.
(2016)
Activation of Muscarinic M1 Acetylcholine Receptors Induces Long-Term Potentiation in the Hippocampus.
Cereb Cortex.
26:414
PMID: 26472558 -
Patel et al.
(2016)
Context-Dependent Modulation of GABAAR-Mediated Tonic Currents.
J Neurosci.
36:607
PMID: 26758848 -
Herman et al.
(2016)
A cholinergic basal forebrain feeding circuit modulates appetite suppression
Nature.
538:253
PMID: 27698417 -
Selten et al.
(2016)
Increased GABAB receptor signaling in a rat model for schizophrenia
Scientific Reports.
6:34240
PMID: 27687783 -
Imlach et al.
(2016)
Glycinergic dysfunction in a subpopulation of dorsal horn interneurons in a rat model of neuropathic pain
Scientific Reports.
6:37104
PMID: 27841371 -
Cui et al.
(2016)
Endocannabinoid dynamics gate spike-timing dependent depression and potentiation.
Elife.
5:e13185
PMID: 26920222 -
Ferando et al.
(2016)
Diminished KCC2 confounds synapse specificity of LTP during senescence.
Nat Neurosci.
19:1197
PMID: 27500406 -
Pan et al.
(2016)
Neuronal firing patterns outweigh circuitry oscillations in parkinsonian motor control.
J Clin Invest.
126:4516
PMID: 27797341 -
Ishibashi et al.
(2016)
Hypocretin/Orexin Peptides Alter Spike Encoding by Serotonergic Dorsal Raphe Neurons through Two Distinct Mechanisms That Increase the Late Afterhyperpolarization.
J Neurosci.
36:10097
PMID: 27683906 -
Pirbhoy et al.
(2016)
Synaptic activation of ribosomal protein S6 phosphorylation occurs locally in activated dendritic domains.
Learn Mem.
23:255
PMID: 27194793 -
Zhang et al.
(2016)
Signaling mechanism for modulation by ATP of glycine receptors on rat retinal ganglion cells.
Sci Rep.
6:28938
PMID: 27357477 -
Pigott and Garthwaite
(2016)
Nitric Oxide Is Required for L-Type Ca(2+) Channel-Dependent Long-Term Potentiation in the Hippocampus.
Front Synaptic Neurosci.
8:17
PMID: 27445786 -
Dilger et al.
(2015)
Absence of plateau potentials in dLGN cells leads to a breakdown in retinogeniculate refinement.
J Neurosci.
35:3652
PMID: 25716863 -
Brzosko et al.
(2015)
Retroactive modulation of spike timing-dependent plasticity by DA.
Elife.
4
PMID: 26516682 -
Li et al.
(2015)
The Posterodorsal Medial Amygdala Regulates the Timing of Puberty Onset in Female Rats.
Endocrinology.
156:3725
PMID: 26252061 -
Baltz and Voigt
(2015)
Interaction of electrically evoked activity with intrinsic dynamics of cultured cortical networks with and without functional fast GABAergic synaptic transmission.
Front Cell Neurosci.
9:272
PMID: 26236196 -
Noh et al.
(2015)
ATRX tolerates activity-dependent histone H3 methyl/phos switching to maintain repetitive element silencing in neurons.
Proc Natl Acad Sci U S A.
112:6820
PMID: 25538301 -
Hou et al.
(2015)
MicroRNA miR124 is required for the expression of homeostatic synaptic plasticity.
Nat Commun.
6:10045
PMID: 26620774 -
Liu et al.
(2015)
Morphological and physiological evidence of a synaptic connection between the lateral parabrachial nucleus and neurons in the A7 catecholamine cell group in rats.
J Biomed Sci.
22:79
PMID: 26385355 -
Xue et al.
(2015)
Structural elements that underlie Doc2β function during asynchronous synaptic transmission.
Proc Natl Acad Sci U S A.
112:E4316
PMID: 26195798 -
Gerhold et al.
(2015)
Pronociceptive and Antinociceptive Effects of Bupren. in the Spinal Cord Dorsal Horn Cover a Dose Range of Four Orders of Magnitude.
J Neurosci.
35:9580
PMID: 26134641 -
Dorris et al.
(2015)
Intrinsic excitability varies by sex in prepubertal striatal medium spiny neurons.
J Neurophysiol.
113:720
PMID: 25376786 -
Sexton and Gelder
(2015)
G-Protein Coupled Receptor Kinase 2 Minimally Regulates Melanopsin Activity in Intrinsically Photosensitive Retinal Ganglion Cells.
PLoS One.
10:e0128690
PMID: 26069965 -
Medrihan et al.
(2015)
Asynchronous GABA Release Is a Key Determinant of Tonic Inhibition and Controls Neuronal Excitability: A Study in the Synapsin II-/- Mouse.
Cereb Cortex.
25:3356
PMID: 24962993 -
Savotchenko et al.
(2015)
Neuraminidase inhibition primes short-term depression and suppresses long-term potentiation of synaptic transmission in the rat hippocampus.
Neural Plast.
2015:908190
PMID: 25802763 -
Sobieski et al.
(2015)
Loss of Local Astrocyte Support Disrupts Action Potential Propagation and Glutamate Release Synchrony from Unmyelinated Hippocampal Axon Terminals In Vitro.
J Neurosci.
35:11105
PMID: 26245971 -
Telese et al.
(2015)
LRP8-Reelin-Regulated Neuronal Enhancer Signature Underlying Learning and Memory Formation.
Neuron.
86:696
PMID: 25892301 -
Pasca et al.
(2015)
Functional cortical neurons and astrocytes from human pluripotent stem cells in 3D culture.
Nat Methods.
12:671
PMID: 26005811 -
Tseng et al.
(2015)
Giant ankyrin-G stabilizes somatodendritic GABAergic synapses through opposing endocytosis of GABAA receptors.
Proc Natl Acad Sci U S A.
112:1214
PMID: 25552561 -
Arama et al.
(2015)
GABAA receptor activity shapes the formation of inhibitory synapses between developing medium spiny neurons.
Front Cell Neurosci.
9:290
PMID: 26300728 -
Eckel et al.
(2015)
Activation of calcineurin underlies altered trafficking of α2 subunit containing GABAA receptors during prolonged epileptiform activity.
Neuropharmacology.
88:82
PMID: 25245802 -
Campbell et al.
(2015)
GABAergic disinhibition and impaired KCC2 cotransporter activity underlie tumor-associated epilepsy.
Glia.
63:23
PMID: 25066727 -
Ciani et al.
(2015)
Wnt signalling tunes neurotransmitter release by directly targeting Synaptotagmin-1.
Nat Commun.
6:8302
PMID: 26400647 -
Park et al.
(2015)
Channel-mediated astrocytic glutamate modulates hippocampal synaptic plasticity by activating postsynaptic NMDA receptors.
Mol Brain.
8:7
PMID: 25645137 -
Vossel et al.
(2015)
Tau reduction prevents Aβ-induced axonal transport deficits by blocking activation of GSK3β.
J Cell Biol.
209:419
PMID: 25963821 -
Morini et al.
(2015)
Subventricular zone neural progenitors reverse TNF-α effects in cortical neurons.
Stem Cell Res Ther.
6:166
PMID: 26345473 -
Haselmann et al.
(2015)
Interactions of Human Autoantibodies with Hippocampal GABAergic Synaptic Transmission - Analyzing Antibody-Induced Effects ex vivo.
Front Neurol.
6:136
PMID: 26124746 -
Birnbaum et al.
(2015)
Calcium flux-independent NMDA receptor activity is required for Aβ oligomer-induced synaptic loss.
Cell Death Dis.
6:e1791
PMID: 26086964 -
Taylor-Burds et al.
(2015)
Chloride Accumulators NKCC1 and AE2 in Mouse GnRH Neurons: Implications for GABAA Mediated Excitation.
PLoS One.
10:e0131076
PMID: 26110920 -
Rosa et al.
(2015)
Neuron-glia signaling in developing retina mediated by neurotransmitter spillover.
Elife.
4
PMID: 26274565 -
Campbell et al.
(2015)
Functional changes in glutamate transporters and astrocyte biophysical properties in a rodent model of focal cortical dysplasia.
Front Cell Neurosci.
8:425
PMID: 25565960 -
Sharma et al.
(2015)
Histone deacetylase 3 inhibition re-establishes synaptic tagging and capture in aging through the activation of nuclear factor κ B.
Sci Rep.
5:16616
PMID: 26577291 -
Curcio et al.
(2015)
Brain ischemia downregulates the neuroprotective GDNF-Ret signaling by a calpain-dependent mechanism in cultured hippocampal neurons.
Cell Death Dis.
6:e1645
PMID: 25675305 -
Stephen et al.
(2015)
Miro1 Regulates Activity-Driven Positioning of Mitochondria within Astrocytic Processes Apposed to Synapses to Regulate Intracellular Calcium Signaling.
J Neurosci.
35:15996
PMID: 26631479 -
Lee et al.
(2015)
Involvement of cAMP-guanine nucleotide exchange factor II in hippocampal long-term depression and behavioral flexibility.
Mol Brain.
8:38
PMID: 26104314 -
Yan et al.
(2015)
PacT. induces acute pain via directly activating toll like receptor 4.
Mol Pain.
11:10
PMID: 25868824 -
Polito et al.
(2015)
Selective Effects of PDE10A Inhibitors on Striatopallidal Neurons Require Phosphatase Inhibition by DARPP-32(1,2,3).
Eneuro.
2
PMID: 26465004 -
Puranam et al.
(2015)
Disruption of Fgf13 causes synaptic excitatory-inhibitory imbalance and genetic epilepsy and febrile seizures plus.
J Neurosci.
35:8866
PMID: 26063919 -
Baquero et al.
(2015)
Developmental changes in synaptic distribution in arcuate nucleus neurons.
J Neurosci.
35:8558
PMID: 26041922 -
John et al.
(2015)
Functional α7 nicotinic receptors are expressed on immature granule cells of the postnatal dentate gyrus.
Brain Res.
1601:15
PMID: 25553616 -
Garthwaite et al.
(2015)
Nitric oxide targets oligodendrocytes and promotes their morphological differentiation.
Glia.
63:383
PMID: 25327839 -
Reifler et al.
(2015)
The rat retina has five types of ganglion-cell photoreceptors.
Exp Eye Res.
130:17
PMID: 25450063 -
Zhu et al.
(2015)
Different patterns of electrical activity lead to long-term potentiation by activating different intracellular pathways.
J Neurosci.
35:621
PMID: 25589756 -
Gao et al.
(2015)
Dendritic morphology, synaptic transmission, and activity of mature granule cells born following PilC-induced status epilepticus in the rat.
Front Cell Neurosci.
9:384
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Zhong et al.
(2015)
BDNF interacts with endocannabinoids to regulate cocaine-induced synaptic plasticity in mouse midbrain DA neurons.
J Neurosci.
35:4469
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Cramer et al.
(2015)
Abnormal excitability and episodic low-frequency oscillations in the cerebral cortex of the tottering mouse.
J Neurosci.
35:5664
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Cooke et al.
(2015)
Visual recognition memory, manifested as long-term habituation, requires synaptic plasticity in V1.
Nat Neurosci.
18:262
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Duménieu et al.
(2015)
Afterhyperpolarization (AHP) regulates the frequency and timing of action potentials in the mitral cells of the olfactory bulb: role of olfactory experience.
Physiol Rep.
3
PMID: 26019289 -
Wang et al.
(2015)
Apamin Boosting of Synaptic Potentials in CaV2.3 R-Type Ca2+ Channel Null Mice.
PLoS One.
10:e0139332
PMID: 26418566 -
Lamanna et al.
(2015)
A pre-docking source for the power-law behavior of spontaneous quantal release: application to the analysis of LTP.
Front Cell Neurosci.
9:44
PMID: 25741239 -
Pardi et al.
(2015)
Differential inhibition onto developing and mature granule cells generates high-frequency filters with variable gain.
Elife.
4:e08764
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Ghosh et al.
(2015)
NE Modulates Pyramidal Cell Synaptic Properties in the Anterior Piriform Cortex of Mice: Age-Dependent Effects of β-adrenoceptors.
Front Cell Neurosci.
9:450
PMID: 26635530 -
Kardamakis et al.
(2015)
Tectal microcircuit generating visual selection commands on gaze-controlling neurons.
Proc Natl Acad Sci U S A.
112:E1956
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Mapelli et al.
(2015)
The effect of Dflu. on neuronal communication at a central synapse.
PLoS One.
10:e0123534
PMID: 25849222 -
Hososhima et al.
(2015)
Kinetic evaluation of photosensitivity in bi-stable variants of chimeric channelrhodopsins.
PLoS One.
10:e0119558
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Tang et al.
(2015)
Modulation of AMPA receptor mediated current by nicotinic acetylcholine receptor in layer I neurons of rat prefrontal cortex.
Sci Rep.
5:14099
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Costa et al.
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Novel agonists for serotonin 5-HT7 receptors reverse metabotropic glutamate receptor-mediated long-term depression in the hippocampus of wild-type and Fmr1 KO mice, a model of Fragile X Syndrome.
Front Behav Neurosci.
9:65
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Malvaez et al.
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Basolateral amygdala rapid glutamate release encodes an outcome-specific representation vital for reward-predictive cues to selectively invigorate reward-seeking actions.
Sci Rep.
5:12511
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Toda and Huganir
(2015)
Regulation of AMPA receptor phosphorylation by the neuropeptide PACAP38.
Proc Natl Acad Sci U S A.
112:6712
PMID: 25964356 -
Williams and Hablitz
(2015)
Differential modulation of repetitive firing and synchronous network activity in neocortical interneurons by inhibition of A-type K(+) channels and Ih.
Front Cell Neurosci.
9:89
PMID: 25852481 -
Morrie and Feller
(2015)
An Asymmetric Increase in Inhibitory Synapse Number Underlies the Development of a Direction Selective Circuit in the Retina.
J Neurosci.
35:9281
PMID: 26109653 -
Sengupta and Thirumalai
(2015)
AMPA receptor mediated synaptic excitation drives state-dependent bursting in Purkinje neurons of zebrafish larvae.
Elife.
4
PMID: 26416140 -
Galván et al.
(2015)
Synapse-specific compartmentalization of signaling cascades for LTP induction in CA3 interneurons.
Neuroscience.
290:332
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Crook et al.
(2014)
A synaptic signature for ON- and OFF-center parasol ganglion cells of the primate retina.
Vis Neurosci.
31:57
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Dale et al.
(2014)
Vort. disinhibits pyramidal cell function and enhances synaptic plasticity in the rat hippocampus.
J Psychopharmacol.
28:891
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Mohn et al.
(2014)
Adenomatous polyposis coli protein deletion leads to cognitive and autism-like disabilities.
Mol Psychiatry.
19:1133
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Wang et al.
(2014)
Accumulation of GABAergic neurons, causing a focal ambient GABA gradient, and downregulation of KCC2 are induced during microgyrus formation in a mouse model of polymicrogyria.
Cereb Cortex.
24:1088
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Gaffaney et al.
(2014)
Mutations that disrupt Ca2+-binding activity endow Doc2β with novel functional properties during synaptic transmission.
Mol Biol Cell.
25:481
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Lee et al.
(2014)
Long-term depression-inducing stimuli promote cleavage of the synaptic adhesion molecule NGL-3 through NMDA receptors, matrix metalloproteinases and presenilin/γ-secretase.
Philos Trans R Soc Lond B Biol Sci.
369:20130158
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Ivanov et al.
(2014)
Glycolysis and oxidative phosphorylation in neurons and astrocytes during network activity in hippocampal slices.
J Cereb Blood Flow Metab.
34:397
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Bemben et al.
(2014)
CaMKII phosphorylation of neuroligin-1 regulates excitatory synapses.
Nat Neurosci.
17:56
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Hodges et al.
(2014)
α-Actinin-2 mediates spine morphology and assembly of the post-synaptic density in hippocampal neurons.
PLoS One.
9:e101770
PMID: 25007055 -
Armbrust et al.
(2014)
Mutant β-III spectrin causes mGluR1α mislocalization and functional deficits in a mouse model of spinocerebellar ataxia type 5.
J Neurosci.
34:9891
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Albrecht et al.
(2014)
Inhibitory projections from the ventral nucleus of the trapezoid body to the medial nucleus of the trapezoid body in the mouse.
Front Neural Circuits.
8:83
PMID: 25120436 -
Qi et al.
(2014)
Longitudinal testing of hippocampal plasticity reveals the onset and maintenance of endogenous human Aβ-induced synaptic dysfunction in individual freely behaving pre-plaque transgenic rats: rapid reversal by anti-Aβ agents.
Acta Neuropathol Commun.
2:175
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Mirante et al.
(2014)
Distinct molecular components for thalamic- and cortical-dependent plasticity in the lateral amygdala.
Front Mol Neurosci.
7:62
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Woo et al.
(2014)
Isoliquiritigenin, a chalcone compound, enhances spontaneous inhibitory postsynaptic response.
Exp Neurobiol.
23:163
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Chuhma et al.
(2014)
DA neurons control striatal cholinergic neurons via regionally heterogeneous DA and glutamate signaling.
Neuron.
81:901
PMID: 24559678 -
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Customer Reviews for D-AP5 (6)
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Species: MouseAssay Type: In VitroCell Line/Tissue: Mixed neuron-gliaD-AP5 (100 μM)Incubate for 24h
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Species: RatAssay Type: In VitroCell Line/Tissue: Sprague-Dawley rats primary neuronal10 μM for 2 h
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Species: MouseAssay Type: In Vivo10uM D-AP5
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Species: MouseAssay Type: In VivoWe delivered this drug intracranially in combination with DNQX to block glutamatergic transmission in the mouse VTA. Product was highly soluble and worked well and as described, producing a robust decrease in place preference behavior.
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Species: MouseCell Line/Tissue: LungGood reproducibility
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Species: RatAssay Type: In Vivoin in-vivo studies
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