
TIM-3 Products
TIM-3 (T cell immunoglobulin and mucin domain-3), also known as HAVCR2 is an immunosuppressive protein that enhances tolerance and inhibits anti-tumor immunity. It is upregulated on several populations of activated myeloid cells (macrophage, monocyte, dendritic cell, microglia, mast cell) and T cells (Th1, CD8+, NK, Treg). TIM-3 ligation by Galectin-9 attenuates CD8+ and Th1 cell responses and promotes the activity of Treg and myeloid derived suppressor cells. Dendritic cell-expressed TIM-3 dampens inflammation by enabling the phagocytosis of apoptotic cells and the cross-presentation of apoptotic cell antigens. TIM-3 also binds the alarmin HMGB1, thereby preventing the activation of TLRs in response to released tumor cell DNA.
70 results for "TIM-3" in Products
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TIM-3 Products
TIM-3 (T cell immunoglobulin and mucin domain-3), also known as HAVCR2 is an immunosuppressive protein that enhances tolerance and inhibits anti-tumor immunity. It is upregulated on several populations of activated myeloid cells (macrophage, monocyte, dendritic cell, microglia, mast cell) and T cells (Th1, CD8+, NK, Treg). TIM-3 ligation by Galectin-9 attenuates CD8+ and Th1 cell responses and promotes the activity of Treg and myeloid derived suppressor cells. Dendritic cell-expressed TIM-3 dampens inflammation by enabling the phagocytosis of apoptotic cells and the cross-presentation of apoptotic cell antigens. TIM-3 also binds the alarmin HMGB1, thereby preventing the activation of TLRs in response to released tumor cell DNA.
70 results for "TIM-3" in Products
Clone 344823 was used by HLDA to establish CD designation
Clonality : | Monoclonal |
Host : | Rat IgG2a Clone #344823 |
Applications : | Flow Cytometry |
Design and order Simple Plex cartridges tailor made to meet your needs with customizable Simple Plex Assay panels for the Ella platform.
Luminex High Performance Assays go through rigorous development, validation, and quality control testing to ensure you are getting the best performance out of your multiplex assay. Panels are customizable so you can order a selection of the analytes or the entire panel.
Contains 4 membranes - each spotted in duplicate with 105 different cytokine antibodies
Recombinant Monoclonal Antibody.
Clonality : | Monoclonal |
Host : | Rabbit IgG Clone #2321C |
Applications : | CyTOF-ready, Flow Cytometry, Immunohistochemistry, Western Blot |
Sensitivity : | 8.75 pg/mL |
Assay Range : | 31.3 - 2,000 pg/mL (Cell Culture Supernates, Cell Lysates, Serum, EDTA Plasma, Heparin Plasma, Urine) |
Applications : | ELISA |
Assay Range : | 62.5 - 4,000 pg/mL |
Applications : | ELISA |
Clone 344823 was used by HLDA to establish CD designation
Clonality : | Monoclonal |
Host : | Rat IgG2a Clone #344823 |
Applications : | Flow Cytometry |
Biotinylated
Source : | CHO |
Accession # : | AAH63431.1 |
Applications : | Bioactivity |
Clonality : | Polyclonal |
Host : | Goat IgG |
Applications : | CyTOF-ready, Dual RNAscope ISH-IHC, Flow Cytometry, Immunohistochemistry, Knockout Validated, Western Blot |
Source : | NS0 |
Accession # : | Q8TDQ0 |
Applications : | Binding Activity |
Source : | CHO |
Accession # : | AAL65157.1 |
Applications : | Bioactivity |
Simple Plex Human TIM-3 assay kit for use on Ella instrument. Contains cartridge, sample diluent SD13, and wash buffer.
Recombinant Monoclonal Antibody.
Clonality : | Monoclonal |
Host : | Rat IgG2a Clone #344823R |
Applications : | CyTOF-ready, Flow Cytometry |
Clone 344823 was used by HLDA to establish CD designation
Clonality : | Monoclonal |
Host : | Rat IgG2a Clone #344823 |
Applications : | Flow Cytometry |
Clonality : | Monoclonal |
Host : | Rat IgG2a Clone #215008 |
Applications : | Flow Cytometry |
Source : | CHO |
Accession # : | NP_001241644.1 |
Applications : | Bioactivity |
Recombinant Monoclonal Antibody.
Clonality : | Monoclonal |
Host : | Rabbit IgG Clone #2321C |
Applications : | Flow Cytometry |
Recombinant Monoclonal Antibody.
Clonality : | Monoclonal |
Host : | Rabbit IgG Clone #2321C |
Applications : | Flow Cytometry |
Recombinant Monoclonal Antibody.
Clonality : | Monoclonal |
Host : | Rabbit IgG Clone #2321C |
Applications : | Flow Cytometry |
Recombinant Monoclonal Antibody.
Clonality : | Monoclonal |
Host : | Rabbit IgG Clone #2321C |
Applications : | Flow Cytometry |
Clonality : | Monoclonal |
Host : | Rat IgG2a Clone #215015 |
Applications : | Western Blot |
Clonality : | Polyclonal |
Host : | Goat IgG |
Applications : | Flow Cytometry, Western Blot |
Clonality : | Polyclonal |
Host : | Goat IgG |
Applications : | CyTOF-ready, Flow Cytometry, Immunohistochemistry, Western Blot |