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TIM-3 Products
TIM-3 (T cell immunoglobulin and mucin domain-3), also known as HAVCR2 is an immunosuppressive protein that enhances tolerance and inhibits anti-tumor immunity. It is upregulated on several populations of activated myeloid cells (macrophage, monocyte, dendritic cell, microglia, mast cell) and T cells (Th1, CD8+, NK, Treg). TIM-3 ligation by Galectin-9 attenuates CD8+ and Th1 cell responses and promotes the activity of Treg and myeloid derived suppressor cells. Dendritic cell-expressed TIM-3 dampens inflammation by enabling the phagocytosis of apoptotic cells and the cross-presentation of apoptotic cell antigens. TIM-3 also binds the alarmin HMGB1, thereby preventing the activation of TLRs in response to released tumor cell DNA.
70 results for "TIM-3" in Products
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TIM-3 Products
TIM-3 (T cell immunoglobulin and mucin domain-3), also known as HAVCR2 is an immunosuppressive protein that enhances tolerance and inhibits anti-tumor immunity. It is upregulated on several populations of activated myeloid cells (macrophage, monocyte, dendritic cell, microglia, mast cell) and T cells (Th1, CD8+, NK, Treg). TIM-3 ligation by Galectin-9 attenuates CD8+ and Th1 cell responses and promotes the activity of Treg and myeloid derived suppressor cells. Dendritic cell-expressed TIM-3 dampens inflammation by enabling the phagocytosis of apoptotic cells and the cross-presentation of apoptotic cell antigens. TIM-3 also binds the alarmin HMGB1, thereby preventing the activation of TLRs in response to released tumor cell DNA.
70 results for "TIM-3" in Products
Catalog #:
FAB2365R
Flow
Clone 344823 was used by HLDA to establish CD designation
| Clonality : | Monoclonal |
| Host : | Rat IgG2a Clone #344823 |
| Applications : | Flow Cytometry |
Catalog #:
SPCK-PANEL
Design and order Simple Plex cartridges tailor made to meet your needs with customizable Simple Plex Assay panels for the Ella platform.
Catalog #:
FCSTM24
Luminex High Performance Assays go through rigorous development, validation, and quality control testing to ensure you are getting the best performance out of your multiplex assay. Panels are customizable so you can order a selection of the analytes or the entire panel.
Contains 4 membranes - each spotted in duplicate with 105 different cytokine antibodies
WB, Flow, IHC, CyTOF-ready
Recombinant Monoclonal Antibody.
| Clonality : | Monoclonal |
| Host : | Rabbit IgG Clone #2321C |
| Applications : | CyTOF-ready, Flow Cytometry, Immunohistochemistry, Western Blot |
ELISA
| Sensitivity : | 8.75 pg/mL |
| Assay Range : | 31.3 - 2,000 pg/mL (Cell Culture Supernates, Cell Lysates, Serum, EDTA Plasma, Heparin Plasma, Urine) |
| Applications : | ELISA |
ELISA
| Assay Range : | 62.5 - 4,000 pg/mL |
| Applications : | ELISA |
Flow
Clone 344823 was used by HLDA to establish CD designation
| Clonality : | Monoclonal |
| Host : | Rat IgG2a Clone #344823 |
| Applications : | Flow Cytometry |
Catalog #:
AVI10241
BA
Biotinylated
| Source : | CHO |
| Accession # : | AAH63431.1 |
| Applications : | Bioactivity |
WB, Flow, IHC, CyTOF-ready, Dual ISH-IHC, KO
| Clonality : | Polyclonal |
| Host : | Goat IgG |
| Applications : | CyTOF-ready, Dual RNAscope ISH-IHC, Flow Cytometry, Immunohistochemistry, Knockout Validated, Western Blot |
Bind
| Source : | NS0 |
| Accession # : | Q8TDQ0 |
| Applications : | Binding Activity |
Catalog #:
10241-TI
BA
| Source : | CHO |
| Accession # : | AAL65157.1 |
| Applications : | Bioactivity |
Catalog #:
SPCKB-PS-001049
Simple Plex Human TIM-3 assay kit for use on Ella instrument. Contains cartridge, sample diluent SD13, and wash buffer.
Catalog #:
MAB2365R
Flow, CyTOF-ready
Recombinant Monoclonal Antibody.
| Clonality : | Monoclonal |
| Host : | Rat IgG2a Clone #344823R |
| Applications : | CyTOF-ready, Flow Cytometry |
Flow
Clone 344823 was used by HLDA to establish CD designation
| Clonality : | Monoclonal |
| Host : | Rat IgG2a Clone #344823 |
| Applications : | Flow Cytometry |
Flow
| Clonality : | Monoclonal |
| Host : | Rat IgG2a Clone #215008 |
| Applications : | Flow Cytometry |
Catalog #:
10719-TM
BA
| Source : | CHO |
| Accession # : | NP_001241644.1 |
| Applications : | Bioactivity |
Catalog #:
FAB23652G
Flow
Recombinant Monoclonal Antibody.
| Clonality : | Monoclonal |
| Host : | Rabbit IgG Clone #2321C |
| Applications : | Flow Cytometry |
Catalog #:
FAB23652N
Flow
Recombinant Monoclonal Antibody.
| Clonality : | Monoclonal |
| Host : | Rabbit IgG Clone #2321C |
| Applications : | Flow Cytometry |
Catalog #:
FAB23652S
Flow
Recombinant Monoclonal Antibody.
| Clonality : | Monoclonal |
| Host : | Rabbit IgG Clone #2321C |
| Applications : | Flow Cytometry |
Catalog #:
FAB23652T
Flow
Recombinant Monoclonal Antibody.
| Clonality : | Monoclonal |
| Host : | Rabbit IgG Clone #2321C |
| Applications : | Flow Cytometry |
Catalog #:
MAB15291
WB
| Clonality : | Monoclonal |
| Host : | Rat IgG2a Clone #215015 |
| Applications : | Western Blot |
Catalog #:
BAF2365
WB, Flow
| Clonality : | Polyclonal |
| Host : | Goat IgG |
| Applications : | Flow Cytometry, Western Blot |
WB, Flow, IHC, CyTOF-ready
| Clonality : | Polyclonal |
| Host : | Goat IgG |
| Applications : | CyTOF-ready, Flow Cytometry, Immunohistochemistry, Western Blot |
