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TIM-3 Products

TIM-3 (T cell immunoglobulin and mucin domain-3), also known as HAVCR2 is an immunosuppressive protein that enhances tolerance and inhibits anti-tumor immunity. It is upregulated on several populations of activated myeloid cells (macrophage, monocyte, dendritic cell, microglia, mast cell) and T cells (Th1, CD8+, NK, Treg). TIM-3 ligation by Galectin-9 attenuates CD8+ and Th1 cell responses and promotes the activity of Treg and myeloid derived suppressor cells. Dendritic cell-expressed TIM-3 dampens inflammation by enabling the phagocytosis of apoptotic cells and the cross-presentation of apoptotic cell antigens. TIM-3 also binds the alarmin HMGB1, thereby preventing the activation of TLRs in response to released tumor cell DNA.

70 results for "TIM-3" in Products

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TIM-3 Products

TIM-3 (T cell immunoglobulin and mucin domain-3), also known as HAVCR2 is an immunosuppressive protein that enhances tolerance and inhibits anti-tumor immunity. It is upregulated on several populations of activated myeloid cells (macrophage, monocyte, dendritic cell, microglia, mast cell) and T cells (Th1, CD8+, NK, Treg). TIM-3 ligation by Galectin-9 attenuates CD8+ and Th1 cell responses and promotes the activity of Treg and myeloid derived suppressor cells. Dendritic cell-expressed TIM-3 dampens inflammation by enabling the phagocytosis of apoptotic cells and the cross-presentation of apoptotic cell antigens. TIM-3 also binds the alarmin HMGB1, thereby preventing the activation of TLRs in response to released tumor cell DNA.

70 results for "TIM-3" in Products

Contains 4 membranes - each spotted in duplicate with 105 different cytokine antibodies

Clone 344823 was used by HLDA to establish CD designation

WB, Flow, IHC, CyTOF-ready, Dual ISH-IHC, KO

Simple Plex Human TIM-3 assay kit for use on Ella instrument. Contains cartridge, sample diluent SD13, and wash buffer.

WB, Flow, IHC, CyTOF-ready

Recombinant Monoclonal Antibody.

Clone 344823 was used by HLDA to establish CD designation

Flow, CyTOF-reported

Clone 344823 was used by HLDA to establish CD designation

WB, Flow, IHC, CyTOF-ready

Clone 344823 was used by HLDA to establish CD designation

AgAct

Clone 344823 was used by HLDA to establish CD designation

Flow, CyTOF-ready

Recombinant Monoclonal Antibody.

BA
BA

Clone 344823 was used by HLDA to establish CD designation

WB, Flow
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