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TIM-3 Products
TIM-3 (T cell immunoglobulin and mucin domain-3), also known as HAVCR2 is an immunosuppressive protein that enhances tolerance and inhibits anti-tumor immunity. It is upregulated on several populations of activated myeloid cells (macrophage, monocyte, dendritic cell, microglia, mast cell) and T cells (Th1, CD8+, NK, Treg). TIM-3 ligation by Galectin-9 attenuates CD8+ and Th1 cell responses and promotes the activity of Treg and myeloid derived suppressor cells. Dendritic cell-expressed TIM-3 dampens inflammation by enabling the phagocytosis of apoptotic cells and the cross-presentation of apoptotic cell antigens. TIM-3 also binds the alarmin HMGB1, thereby preventing the activation of TLRs in response to released tumor cell DNA.
70 results for "TIM-3" in Products
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TIM-3 Products
TIM-3 (T cell immunoglobulin and mucin domain-3), also known as HAVCR2 is an immunosuppressive protein that enhances tolerance and inhibits anti-tumor immunity. It is upregulated on several populations of activated myeloid cells (macrophage, monocyte, dendritic cell, microglia, mast cell) and T cells (Th1, CD8+, NK, Treg). TIM-3 ligation by Galectin-9 attenuates CD8+ and Th1 cell responses and promotes the activity of Treg and myeloid derived suppressor cells. Dendritic cell-expressed TIM-3 dampens inflammation by enabling the phagocytosis of apoptotic cells and the cross-presentation of apoptotic cell antigens. TIM-3 also binds the alarmin HMGB1, thereby preventing the activation of TLRs in response to released tumor cell DNA.
70 results for "TIM-3" in Products
Contains 4 membranes - each spotted in duplicate with 105 different cytokine antibodies
Clone 344823 was used by HLDA to establish CD designation
| Clonality : | Monoclonal |
| Host : | Rat IgG2a Clone #344823 |
| Applications : | Flow Cytometry |
Design and order Simple Plex cartridges tailor made to meet your needs with customizable Simple Plex Assay panels for the Ella platform.
Luminex High Performance Assays go through rigorous development, validation, and quality control testing to ensure you are getting the best performance out of your multiplex assay. Panels are customizable so you can order a selection of the analytes or the entire panel.
| Sensitivity : | 8.75 pg/mL |
| Assay Range : | 31.3 - 2,000 pg/mL (Cell Culture Supernates, Cell Lysates, Serum, EDTA Plasma, Heparin Plasma, Urine) |
| Applications : | ELISA |
| Clonality : | Polyclonal |
| Host : | Goat IgG |
| Applications : | CyTOF-ready, Dual RNAscope ISH-IHC, Flow Cytometry, Immunohistochemistry, Knockout Validated, Western Blot |
Simple Plex Human TIM-3 assay kit for use on Ella instrument. Contains cartridge, sample diluent SD13, and wash buffer.
Create your custom Simple Plex cartridge for up to 8 targets. Choose from more than 250 targets across multiple species.
| Source : | NS0 |
| Accession # : | Q8TDQ0 |
| Applications : | Binding Activity |
Recombinant Monoclonal Antibody.
| Clonality : | Monoclonal |
| Host : | Rabbit IgG Clone #2321C |
| Applications : | CyTOF-ready, Flow Cytometry, Immunohistochemistry, Western Blot |
Clone 344823 was used by HLDA to establish CD designation
| Clonality : | Monoclonal |
| Host : | Rat IgG2a Clone #344823 |
| Applications : | Flow Cytometry |
Clone 344823 was used by HLDA to establish CD designation
| Clonality : | Monoclonal |
| Host : | Rat IgG2a Clone #344823 |
| Applications : | CyTOF-ready, Flow Cytometry |
| Clonality : | Polyclonal |
| Host : | Goat IgG |
| Applications : | CyTOF-ready, Flow Cytometry, Immunohistochemistry, Western Blot |
| Clonality : | Monoclonal |
| Host : | Rat IgG2a Clone #215008 |
| Applications : | Flow Cytometry |
Clone 344823 was used by HLDA to establish CD designation
| Clonality : | Monoclonal |
| Host : | Rat IgG2a Clone #344823 |
| Applications : | Flow Cytometry |
| Clonality : | Monoclonal |
| Host : | Rat IgG1 Clone #344801 |
| Applications : | Functional Assay |
Clone 344823 was used by HLDA to establish CD designation
| Clonality : | Monoclonal |
| Host : | Rat IgG2a Clone #344823 |
| Applications : | Flow Cytometry |
Recombinant Monoclonal Antibody.
| Clonality : | Monoclonal |
| Host : | Rat IgG2a Clone #344823R |
| Applications : | CyTOF-ready, Flow Cytometry |
| Clonality : | Monoclonal |
| Host : | Rat IgG2a Clone #215008 |
| Applications : | Flow Cytometry |
| Clonality : | Monoclonal |
| Host : | Rat IgG2a Clone #215008 |
| Applications : | Flow Cytometry |
| Assay Range : | 62.5 - 4,000 pg/mL |
| Applications : | ELISA |
| Source : | CHO |
| Accession # : | NP_001241644.1 |
| Applications : | Bioactivity |
| Source : | CHO |
| Accession # : | AAL65157.1 |
| Applications : | Bioactivity |
Clone 344823 was used by HLDA to establish CD designation
| Clonality : | Monoclonal |
| Host : | Rat IgG2a Clone #344823 |
| Applications : | Flow Cytometry |
| Clonality : | Monoclonal |
| Host : | Rat IgG2a Clone #215015 |
| Applications : | Western Blot |
| Clonality : | Polyclonal |
| Host : | Goat IgG |
| Applications : | Flow Cytometry, Western Blot |
