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TIM-3: Antibodies

TIM-3 (T cell immunoglobulin and mucin domain-3), also known as HAVCR2 is an immunosuppressive protein that enhances tolerance and inhibits anti-tumor immunity. It is upregulated on several populations of activated myeloid cells (macrophage, monocyte, dendritic cell, microglia, mast cell) and T cells (Th1, CD8+, NK, Treg). TIM-3 ligation by Galectin-9 attenuates CD8+ and Th1 cell responses and promotes the activity of Treg and myeloid derived suppressor cells. Dendritic cell-expressed TIM-3 dampens inflammation by enabling the phagocytosis of apoptotic cells and the cross-presentation of apoptotic cell antigens. TIM-3 also binds the alarmin HMGB1, thereby preventing the activation of TLRs in response to released tumor cell DNA.

50 results for "TIM-3 Primary Antibodies" in Products

TIM-3: Antibodies

TIM-3 (T cell immunoglobulin and mucin domain-3), also known as HAVCR2 is an immunosuppressive protein that enhances tolerance and inhibits anti-tumor immunity. It is upregulated on several populations of activated myeloid cells (macrophage, monocyte, dendritic cell, microglia, mast cell) and T cells (Th1, CD8+, NK, Treg). TIM-3 ligation by Galectin-9 attenuates CD8+ and Th1 cell responses and promotes the activity of Treg and myeloid derived suppressor cells. Dendritic cell-expressed TIM-3 dampens inflammation by enabling the phagocytosis of apoptotic cells and the cross-presentation of apoptotic cell antigens. TIM-3 also binds the alarmin HMGB1, thereby preventing the activation of TLRs in response to released tumor cell DNA.

50 results for "TIM-3 Primary Antibodies" in Products

WB, Flow, IHC, CyTOF-ready

Recombinant Monoclonal Antibody.

Clone 344823 was used by HLDA to establish CD designation

WB, Flow, IHC, CyTOF-ready, Dual ISH-IHC, KO
Flow, CyTOF-ready

Recombinant Monoclonal Antibody.

Flow, CyTOF-reported

Clone 344823 was used by HLDA to establish CD designation

Clone 344823 was used by HLDA to establish CD designation

Catalog #: FAB23652T
Flow

Recombinant Monoclonal Antibody.

Catalog #: FAB23652S
Flow

Recombinant Monoclonal Antibody.

WB, Flow
WB, Flow, IHC, CyTOF-ready
AgAct

Clone 344823 was used by HLDA to establish CD designation

Flow, CyTOF-ready

Recombinant Monoclonal Antibody.

Clone 344823 was used by HLDA to establish CD designation

Catalog #: FAB2365V
Flow

Clone 344823 was used by HLDA to establish CD designation

Catalog #: FAB23652N
Flow

Recombinant Monoclonal Antibody.

Catalog #: FAB23652G
Flow

Recombinant Monoclonal Antibody.

Catalog #: FAB1529RN
Flow

Clone 344823 was used by HLDA to establish CD designation

Catalog #: FAB1529RS
Flow
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