Human TIM-3 Antibody
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Key Product Details
Species Reactivity: | Human |
Immunogen: |
Mouse myeloma cell line NS0-derived recombinant human TIM‑3 Ser22-Arg200 Accession # Q8TDQ0 |
Applications: | CyTOF-ready, Dual RNAscope ISH-IHC, Flow Cytometry, Immunohistochemistry, Knockout Validated, Western Blot |
Label: | Unconjugated |
Source: | Polyclonal Goat IgG |
Specificity: |
Detects human TIM-3 in direct ELISAs and Western blots. In direct ELISAs, approximately 5% cross-reactivity with recombinant mouse (rm) TIM‑3 is observed and less than 1% cross-reactivity with recombinant human TIM-1, rmTIM-1, and rmTIM-2 is observed. |
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Citations for Human TIM-3 Antibody (17)
Citations are publications that use Bio-Techne products. Selected citations for Human TIM-3 Antibody include:
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Species: Human
Sample Types: Whole Tissue
Applications: IHCN Ebata et al. (2021), Molecular Classification and Tumor Microenvironment Characterization of Gallbladder Cancer by Comprehensive Genomic and Transcriptomic Analysis Cancers, 13(4).
PMID: 33578820 -
Species: Human
Sample Types: Whole Tissue
Applications: IHCW Zhong et al. (2021), High levels of Tim-3+Foxp3+Treg cells in the tumor microenvironment is a prognostic indicator of poor survival of diffuse large B cell lymphoma patients International immunopharmacology, 96(0):107662.
PMID: 33864956 -
Species: Human
Sample Types: Whole Cells
Applications: Flow CytometryDM Franchini et al. (2019), Microtubule-Driven Stress Granule Dynamics Regulate Inhibitory Immune Checkpoint Expression in T Cells Cell Rep, 26(1):94-107.e7.
PMID: 30605689 -
Species: Human
Sample Types: Cell Lysates
Applications: Western BlotD Zhao et al. (2017), Frontline Science: Tim-3-mediated dysfunctional engulfment of apoptotic cells in SLE J. Leukoc. Biol., 0(0).
PMID: 28754800 -
Species: Human
Sample Types: Whole Cells
Applications: ICCJA Schwartz et al. (2017), Tim-3 is a Marker of Plasmacytoid Dendritic Cell Dysfunction during HIV Infection and Is Associated with the Recruitment of IRF7 and p85 into Lysosomes and with the Submembrane Displacement of TLR9 J. Immunol, 0(0).
PMID: 28264968 -
Species: Human
Sample Types: Whole Tissue
Applications: IHCJ Zhao et al. (2017), Secretion of IFN-? Associated with Galectin-9 Production by Pleural Fluid Cells from a Patient with Extrapulmonary Tuberculosis Int J Mol Sci, 18(7).
PMID: 28657598 -
Species: Human
Sample Types: Whole Tissue
Applications: IHCTO Mohammed et al. (2017), Galectin-9 as a Predictive Marker for the Onset of Immune-Related Adverse Effects Associated with Anti-CCR4 MoAb Therapy in Patients with Adult T Cell Leukemia Tohoku J. Exp. Med, 241(3):201-208.
PMID: 28321034 -
Species: Human
Sample Types: Whole Tissue
Applications: IHC-P(2016), Comprehensive analyses of tumor immunity: implications for cancer immunotherapy Genome Biol, 17(1):174.
PMID: 27549193 -
Species: Human
Sample Types: Cell Lysates
Applications: Western BlotGuangxiang Luo (2016), TIM-1 promotes hepatitis C virus cell attachment and infection J. Virol., 0(0).
PMID: 27807228 -
Species: Human
Sample Types: Cell Culture Supernates
Clayton K et al. (2015), Soluble T cell immunoglobulin mucin domain 3 is shed from CD8+ T cells by the sheddase ADAM10, is increased in plasma during untreated HIV infection, and correlates with HIV disease progression. J Virol, 89(7):3723-36.
PMID: 25609823 -
Species: Human
Sample Types: Cell Lysates
Applications: ImmunoprecipitationClayton K et al. (2014), T cell Ig and mucin domain-containing protein 3 is recruited to the immune synapse, disrupts stable synapse formation, and associates with receptor phosphatases. J Immunol, 192(2):782-91.
PMID: 24337741 -
Species: Human
Sample Types: Whole Cells
Applications: Flow CytometryMoller-Tank S et al. (2014), Characterizing functional domains for TIM-mediated enveloped virus entry. J Virol, 88(12):6702-13.
PMID: 24696470 -
Species: Human
Sample Types: Whole Tissue
Applications: IHCYan J et al. (2013), Tim-3 expression defines regulatory T cells in human tumors. PLoS ONE, 8(3):e58006.
PMID: 23526963 -
Species: Human
Sample Types: Whole Tissue
Applications: IHC-PJiang et al. (2013), Decreased galectin-9 and increased Tim-3 expression are related to poor prognosis in gastric cancer. PLoS ONE, 8(12):e81799.
PMID: 24339967 -
Species: Human
Sample Types: Cell Lysates
Applications: ImmunoprecipitationVega-Carrascal I et al. (2011), Dysregulation of TIM-3-Galectin-9 Pathway in the Cystic Fibrosis Airways. J. Immunol., 0(0).
PMID: 21263071 -
Species: Human
Sample Types: Whole Cells
Applications: NeutralizationZhang Y et al. (2011), Tim-3 negatively regulates IL-12 expression by monocytes in HCV infection. PLoS ONE, 6(5):e19664.
PMID: 21637332 -
Species: Human
Sample Types: Whole Cells
Applications: ICCSeki M et al. (2007), Beneficial effect of galectin 9 on rheumatoid arthritis by induction of apoptosis of synovial fibroblasts. Arthritis Rheum., 56(12):3968-76.
PMID: 18050192
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Customer Reviews (1)
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Application: Western BlotSample Tested: Jurkat human acute T cell leukemia cell line,K562 human chronic myelogenous leukemia cell line,RPMI 8226 human multiple myeloma cell lineSpecies: HumanVerified Customer | Posted 10/17/2018
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