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TIM-3: Proteins and Enzymes
TIM-3 (T cell immunoglobulin and mucin domain-3), also known as HAVCR2 is an immunosuppressive protein that enhances tolerance and inhibits anti-tumor immunity. It is upregulated on several populations of activated myeloid cells (macrophage, monocyte, dendritic cell, microglia, mast cell) and T cells (Th1, CD8+, NK, Treg). TIM-3 ligation by Galectin-9 attenuates CD8+ and Th1 cell responses and promotes the activity of Treg and myeloid derived suppressor cells. Dendritic cell-expressed TIM-3 dampens inflammation by enabling the phagocytosis of apoptotic cells and the cross-presentation of apoptotic cell antigens. TIM-3 also binds the alarmin HMGB1, thereby preventing the activation of TLRs in response to released tumor cell DNA.
7 results for "TIM-3 Proteins and Enzymes" in Products
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TIM-3: Proteins and Enzymes
TIM-3 (T cell immunoglobulin and mucin domain-3), also known as HAVCR2 is an immunosuppressive protein that enhances tolerance and inhibits anti-tumor immunity. It is upregulated on several populations of activated myeloid cells (macrophage, monocyte, dendritic cell, microglia, mast cell) and T cells (Th1, CD8+, NK, Treg). TIM-3 ligation by Galectin-9 attenuates CD8+ and Th1 cell responses and promotes the activity of Treg and myeloid derived suppressor cells. Dendritic cell-expressed TIM-3 dampens inflammation by enabling the phagocytosis of apoptotic cells and the cross-presentation of apoptotic cell antigens. TIM-3 also binds the alarmin HMGB1, thereby preventing the activation of TLRs in response to released tumor cell DNA.
7 results for "TIM-3 Proteins and Enzymes" in Products
Catalog #:
AVI10241
BA
Biotinylated
| Source : | CHO |
| Accession # : | AAH63431.1 |
| Applications : | Bioactivity |
Bind
| Source : | NS0 |
| Accession # : | Q8TDQ0 |
| Applications : | Binding Activity |
Catalog #:
10719-TM
BA
| Source : | CHO |
| Accession # : | NP_001241644.1 |
| Applications : | Bioactivity |
Catalog #:
10241-TI
BA
| Source : | CHO |
| Accession # : | AAL65157.1 |
| Applications : | Bioactivity |
Catalog #:
10489-TM
BA
| Source : | NS0 |
| Accession # : | P0C0K5.2 |
| Applications : | Bioactivity |
BA, Bind
| Source : | HEK293 |
| Accession # : | EHH54703 |
| Applications : | Binding Activity, Bioactivity |
Catalog #:
1529-TM
Bind
| Source : | NS0 |
| Accession # : | AAL65156 |
| Applications : | Binding Activity |
