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TIGIT Products

TIGIT (T cell Immunoreceptor with Ig and ITIM domains), also called Vstm3, Vsig9,  and WUCAM, is a transmembrane protein in the CD28 family of the Ig superfamily proteins. TIGIT is expressed on NK cells and subsets of activated, memory and regulatory T cells, and particularly on follicular helper T cells within secondary lymphoid organs. It binds to CD155/PVR/Necl-5 and Nectin-2/CD112/PVRL2 on dendritic cells (DC) and endothelium. Binding of TIGIT by DC induces IL-10 release and inhibits IL-12 production. Ligation of TIGIT on T cells downregulates TCR-mediated activation and subsequent proliferation, while NK cell TIGIT ligation blocks NK cell cytotoxicity. CD155 and Nectin-2 also interact with DNAM-1/CD226 and CD96/Tactile, and TIGIT binding to CD155 can antagonize the effects of DNAM-1. Soluble TIGIT is able to compete with DNAM-1 for CD155 binding and attenuates T cell responses, while mice lacking TIGIT show increased T cell responses and susceptibility to autoimmune challenges.

41 results for "TIGIT" in Products

TIGIT Products

TIGIT (T cell Immunoreceptor with Ig and ITIM domains), also called Vstm3, Vsig9,  and WUCAM, is a transmembrane protein in the CD28 family of the Ig superfamily proteins. TIGIT is expressed on NK cells and subsets of activated, memory and regulatory T cells, and particularly on follicular helper T cells within secondary lymphoid organs. It binds to CD155/PVR/Necl-5 and Nectin-2/CD112/PVRL2 on dendritic cells (DC) and endothelium. Binding of TIGIT by DC induces IL-10 release and inhibits IL-12 production. Ligation of TIGIT on T cells downregulates TCR-mediated activation and subsequent proliferation, while NK cell TIGIT ligation blocks NK cell cytotoxicity. CD155 and Nectin-2 also interact with DNAM-1/CD226 and CD96/Tactile, and TIGIT binding to CD155 can antagonize the effects of DNAM-1. Soluble TIGIT is able to compete with DNAM-1 for CD155 binding and attenuates T cell responses, while mice lacking TIGIT show increased T cell responses and susceptibility to autoimmune challenges.

41 results for "TIGIT" in Products

BA
Flow, Block, CyTOF-ready

Recombinant Monoclonal Antibody.

Catalog #: FAB10532G
Flow

Recombinant Monoclonal Antibody.

Analyzed by SEC-MALS

BA

Biotinylated

Flow, Block, CyTOF-ready
Flow, CyTOF-ready

Recombinant Monoclonal Antibody.

Flow
Catalog #: FAB10532R
Flow

Recombinant Monoclonal Antibody.

Flow
Catalog #: 7267-TG
BA
Catalog #: MAB78981
Block
Flow, IHC, CyTOF-ready
Block
Catalog #: FAB7898R
Flow
Catalog #: FAB7898V
Flow
BA
Catalog #: FAB10532T
Flow

Recombinant Monoclonal Antibody.

Catalog #: FAB72671U
Flow

Recombinant Monoclonal Antibody.

Catalog #: FAB7898U
Flow
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