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TIGIT Products

TIGIT (T cell Immunoreceptor with Ig and ITIM domains), also called Vstm3, Vsig9,  and WUCAM, is a transmembrane protein in the CD28 family of the Ig superfamily proteins. TIGIT is expressed on NK cells and subsets of activated, memory and regulatory T cells, and particularly on follicular helper T cells within secondary lymphoid organs. It binds to CD155/PVR/Necl-5 and Nectin-2/CD112/PVRL2 on dendritic cells (DC) and endothelium. Binding of TIGIT by DC induces IL-10 release and inhibits IL-12 production. Ligation of TIGIT on T cells downregulates TCR-mediated activation and subsequent proliferation, while NK cell TIGIT ligation blocks NK cell cytotoxicity. CD155 and Nectin-2 also interact with DNAM-1/CD226 and CD96/Tactile, and TIGIT binding to CD155 can antagonize the effects of DNAM-1. Soluble TIGIT is able to compete with DNAM-1 for CD155 binding and attenuates T cell responses, while mice lacking TIGIT show increased T cell responses and susceptibility to autoimmune challenges.

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197 results for "TIGIT" in Products

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TIGIT Products

TIGIT (T cell Immunoreceptor with Ig and ITIM domains), also called Vstm3, Vsig9,  and WUCAM, is a transmembrane protein in the CD28 family of the Ig superfamily proteins. TIGIT is expressed on NK cells and subsets of activated, memory and regulatory T cells, and particularly on follicular helper T cells within secondary lymphoid organs. It binds to CD155/PVR/Necl-5 and Nectin-2/CD112/PVRL2 on dendritic cells (DC) and endothelium. Binding of TIGIT by DC induces IL-10 release and inhibits IL-12 production. Ligation of TIGIT on T cells downregulates TCR-mediated activation and subsequent proliferation, while NK cell TIGIT ligation blocks NK cell cytotoxicity. CD155 and Nectin-2 also interact with DNAM-1/CD226 and CD96/Tactile, and TIGIT binding to CD155 can antagonize the effects of DNAM-1. Soluble TIGIT is able to compete with DNAM-1 for CD155 binding and attenuates T cell responses, while mice lacking TIGIT show increased T cell responses and susceptibility to autoimmune challenges.

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197 results for "TIGIT" in Products

ELISA, Flow, IHC, MA, Simple Western
ELISA, IHC, MA
Flow, IHC, CyTOF-ready

Analyzed by SEC-MALS

Flow, Block, CyTOF-ready
Flow
Flow, CyTOF-ready

Recombinant Monoclonal Antibody.

ELISA, Flow, ICC/IF, IHC

Recombinant Monoclonal Antibody

Flow, Block, CyTOF-ready

Recombinant Monoclonal Antibody.

BA
Catalog #: FAB72671N
Flow

Recombinant Monoclonal Antibody.

Catalog #: FAB10532T
Flow

Recombinant Monoclonal Antibody.

Catalog #: FAB10532N
Flow

Recombinant Monoclonal Antibody.

Flow
Block
BA
Catalog #: MAB78981
Block
ELISA, Flow, ICC/IF, IHC

Recombinant Monoclonal Antibody

ELISA, Flow, ICC/IF, IHC

Recombinant Monoclonal Antibody

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