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Sonic Hedgehog/Shh: Proteins and Enzymes
Shh (Sonic Hedgehog) is expressed in embryonic tissues that are critical for the patterning of the developing central nervous system, somite, and limb. It is also involved in whisker, hair, foregut, tooth, and bone development. Shh regulates neural and hematopoietic stem cell fate and is important for thymocyte differentiation and proliferation. In adult tissue Shh is associated with cancer development and tissue remodeling following injury. Palmitoylation and cholesterol addition of Shh contribute to its membrane tethering and assembly into multimers. Lipid modification and multimerization greatly increase Shh signaling potency. Shh can be released from the plasma membrane by the cooperative action of DISP1, SCUBE2, and TACE/ADAM17. Canonical signaling of Shh is mediated by a receptor complex that includes Patched (PTCH1, PTCH2) and Smoothened (SMO).
8 results for "Sonic Hedgehog/Shh Proteins and Enzymes" in Products
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Sonic Hedgehog/Shh: Proteins and Enzymes
Shh (Sonic Hedgehog) is expressed in embryonic tissues that are critical for the patterning of the developing central nervous system, somite, and limb. It is also involved in whisker, hair, foregut, tooth, and bone development. Shh regulates neural and hematopoietic stem cell fate and is important for thymocyte differentiation and proliferation. In adult tissue Shh is associated with cancer development and tissue remodeling following injury. Palmitoylation and cholesterol addition of Shh contribute to its membrane tethering and assembly into multimers. Lipid modification and multimerization greatly increase Shh signaling potency. Shh can be released from the plasma membrane by the cooperative action of DISP1, SCUBE2, and TACE/ADAM17. Canonical signaling of Shh is mediated by a receptor complex that includes Patched (PTCH1, PTCH2) and Smoothened (SMO).
8 results for "Sonic Hedgehog/Shh Proteins and Enzymes" in Products
BA
C-terminal cholesterol, N-terminal fatty acid-modified
| Source : | HEK293 |
| Accession # : | Q15465 |
| Applications : | Bioactivity |
BA
A New rh Shh is Available! C-term cholesterol, N-term fatty acid-modified; 14-fold better activity!
| Source : | E. coli |
| Accession # : | NP_000184.1 |
| Applications : | Bioactivity |
BA
| Source : | E. coli |
| Accession # : | Q62226 |
| Applications : | Bioactivity |
Catalog #:
1845-GMP
BA
Animal-Free
| Source : | E. coli |
| Accession # : | NP_000184.1 |
| Applications : | Bioactivity |
Catalog #:
1314-GMP
BA
Animal-Free
| Source : | E. coli |
| Accession # : | Q15465.1 |
| Applications : | Bioactivity |
BA
A New rh Shh is Available! C-term cholesterol, N-term fatty acid-modified; 250-fold better activity!
BA
| Source : | E. coli |
| Accession # : | Q62226 |
| Applications : | Bioactivity |
Catalog #:
AFL1845
BA
Also available, GMP Shh Protein, Catalog # 1845-GMP! Animal-free and manufactured under GMP guidelines for therapeutic manufacturing applications.
| Source : | E. coli |
| Accession # : | NP_000184.1 |
| Applications : | Bioactivity |
