Sign In / Register
Recombinant Human Sonic Hedgehog/Shh (C24II) N-Terminus Best Seller
Catalog # 1845-SH | R&D Systems, Inc. a Bio-Techne Brand
Key Product Details
Product Specifications
Source
E. coli-derived human Sonic Hedgehog/Shh protein
Cys24-Gly197 (Cys24Ile-Ile), with an N-terminal Met
Cys24-Gly197 (Cys24Ile-Ile), with an N-terminal Met
Purity
>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
Endotoxin Level
<0.01 EU per 1 μg of the protein by the LAL method.
N-terminal Sequence Analysis
Met
Predicted Molecular Mass
20 kDa
SDS-PAGE
22 kDa, reducing conditions
Activity
Measured by its ability to induce alkaline phosphatase production by C3H10T1/2 mouse embryonic fibroblast cells. Nakamura, T. et al. (1997) Biochem. Biophys. Res. Commun. 237:465.
The ED50 for this effect is 0.1-0.4 µg/mL.
The ED50 for this effect is 0.1-0.4 µg/mL.
Scientific Data Images for Recombinant Human Sonic Hedgehog/Shh (C24II) N-Terminus
Recombinant Human Sonic Hedgehog/Shh (C24II) N-Terminus Bioactivity
Recombinant Human Sonic Hedgehog/Shh (C24II), N-Terminus (Catalog # 1845-SH) induces alkaline phosphatase production by the C3H10T1/2 mouse embryonic fibroblast cell line. The ED50 for this effect is 0.1-0.4 μg/mL.
Recombinant Human Sonic Hedgehog/Shh (C24II) N-Terminus SDS-PAGE
1 μg/lane of Recombinant Human Sonic Hedgehog/Shh (C24II), N-Terminus was resolved with SDS-PAGE under reducing (R) conditions and visualized by silver staining, showing a single band at 22 kDa.
Recombinant Human Sonic Hedgehog/Shh (C24II) N-Terminus Mass Spectrometry
MALDI-TOF analysis of Recombinant Human Sonic Hedgehog/Shh (C24II), N-Terminus. The major peak corresponds to the calculated molecular mass, 19814 Da. The minor peak at 20029 is a matrix-associated artifact of the MALDI-TOF.Formulation, Preparation and Storage
Carrier Free
What does CF mean?CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.
What formulation is right for me?In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.
Carrier: 1845-SH
| Formulation | Lyophilized from a 0.2 μm filtered solution in PBS and NaCl with BSA as a carrier protein. |
| Reconstitution | Reconstitute at 100-200 μg/mL in sterile PBS containing at least 0.1% human or bovine serum albumin, and allow up to 24 hours at 2 to 8 °C for complete reconstitution. |
| Shipping | The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Stability & Storage | Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
|
Carrier Free: 1845-SH/CF
| Formulation | Lyophilized from a 0.2 μm filtered solution in PBS and NaCl. |
| Reconstitution | Reconstitute at 100-200 μg/mL in sterile PBS, and allow up to 24 hours at 2 to 8 °C for complete reconstitution. |
| Shipping | The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Stability & Storage | Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
|
Background: Sonic Hedgehog/Shh
N-terminal cysteine and modified by cholesterol addition at its C-terminus (6). These modifications contribute to the membrane tethering of Shh as well as its assembly into various sized multimers (6-9). Lipid modification and multimerization greatly increase Shh-N receptor binding affinity and signaling potency (5, 6, 8, 9). Monomeric and multimeric Shh can be released from the plasma membrane by the cooperative action of DISP1, SCUBE2, and TACE/ADAM17 (10-12). Modifications also extend the effective range of Shh functionality and are required for the development of protein gradients important in tissue morphogenesis (9, 13). Canonical signaling of Shh is mediated by a multicomponent receptor complex that includes Patched (PTCH1, PTCH2) and Smoothened (SMO) (14). The binding of Shh to PTCH releases the basal repression of SMO by PTCH. Shh activity can also be regulated through interactions with heparin, glypicans, and membrane-associated Hip (hedgehog interacting protein) (13, 15, 16).
References
- Briscoe, J. and P.P. Therond (2013) Mol. Cell. Biol. 14:416.
- Aviles, E.C. et al. (2013) Front. Cell. Neurosci. 7:86.
- Xie, J. et al. (2013) OncoTargets Ther. 6:1425.
- Marigo, V. et al. (1995) Genomics 28:44.
- Zeng, X. et al. (2001) Nature 411:716.
- Feng, J. et al. (2004) Development 131:4357.
- Goetz, J.A. et al. (2006) J. Biol. Chem. 281:4087.
- Pepinsky, R.B. et al. (1998) J. Biol. Chem. 273:14037.
- Chen, M.-H. et al. (2004) Genes Dev. 18:641.
- Etheridge, L.A. et al. (2010) Development 137:133.
- Jakobs, P. et al. (2014) J. Cell Sci. 127:1726.
- Dierker, T. et al. (2009) J. Biol. Chem. 284:8013.
- Lewis, P.M. et al. (2001) Cell 105:599.
- Carpenter, D. et al. (1998) Proc. Natl. Acad. Sci. USA 95:13630.
- Filmus, J. and M. Capurro (2014) Matrix Biol. 35:248.
- Chuang, P.-T. and A.P. McMahon (1999) Nature 397:617.
Alternate Names
HHG1, HLP3, HPE3, MCOPCB5, Shh, ShhNC, SMMCI, TPTPS
Gene Symbol
SHH
UniProt
Product Documents for Recombinant Human Sonic Hedgehog/Shh (C24II) N-Terminus
Product Specific Notices for Recombinant Human Sonic Hedgehog/Shh (C24II) N-Terminus
For research use only
Citations for Recombinant Human Sonic Hedgehog/Shh (C24II) N-Terminus (59)
Showing
1
-
10 of
59 publications
Showing All
Filter By:
Search Title:
Citations are publications that use Bio-Techne products. Selected citations for Recombinant Human Sonic Hedgehog/Shh (C24II) N-Terminus include:
-
Species: Human
Sample Types: Whole Cells
Applications: BioassayIto et al. (2023-05-29), Elucidation of HHEX in pancreatic endoderm differentiation using a human iPSC differentiation model Scientific reports
PMID: 37248264 -
Species: Mouse
Sample Types: Whole Cells
Applications: Cell CultureX Li et al. (2022-12-02), Lhx2 is a progenitor-intrinsic modulator of Sonic Hedgehog signaling during early retinal neurogenesis Elife, 2022-111(0).
PMID: 36459481 -
Species: Human
Sample Types: Organoids
Applications: BioassayÖ Karabiyik et al. (2022-12-02), Production of parathyroid-like cells from thyroid stem cells in co-culture environment Medicine, 2022-1101(48):e32009.
PMID: 36482540 -
Species: Human
Sample Types: Organoid
Applications: BioassayJS Fleck et al. (2022-10-05), Inferring and perturbing cell fate regulomes in human brain organoids Nature, 2022-10(0).
PMID: 36198796 -
Species: Mouse
Sample Types: Whole Cells
Applications: Cell CultureDS Lee et al. (2022-09-27), Nuclear Factor I-C Regulates Stemness Genes and Proliferation of Stem Cells in Various Mineralized Tissue through Epithelial-Mesenchymal Interactions in Dental Epithelial Stem Cells Stem Cells International, 2022-02022(0):1092184.
PMID: 36213683 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayJSY Tan et al. (2022-05-16), Parkinson's Disease-Specific Autoantibodies against the Neuroprotective Co-Chaperone STIP1 Cells, 2022-011(10).
PMID: 35626686 -
Species: Mouse
Sample Types: Whole Cells
Applications: BioassayM Lo et al. (2022-05-03), CNPY4 inhibits the Hedgehog pathway by modulating membrane sterol lipids Nature Communications, 2022-013(1):2407.
PMID: 35504891 -
Species: Human
Sample Types: Whole Tissue
Applications: BioassayA Moore et al. (2022-04-07), Loss of Function of the Neural Cell Adhesion Molecule NrCAM Regulates Differentiation, Proliferation and Neurogenesis in Early Postnatal Hypothalamic Tanycytes Frontiers in Neuroscience, 2022-016(0):832961.
PMID: 35464310 -
Species: Human
Sample Types: Whole Cells
Applications: Cell CultureL Torz et al. (2022-03-17), NPFF Decreases Activity of Human Arcuate NPY Neurons: A Study in Embryonic-Stem-Cell-Derived Model International Journal of Molecular Sciences, 2022-023(6).
PMID: 35328681 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayMA Hossain et al. (2022-02-21), Generation and characterization of motor neuron progenitors and motor neurons using metachromatic leukodystrophy-induced pluripotent stem cells Oncogene, 2022-031(0):100852.
PMID: 35782608 -
Species: Human
Sample Types: Organoids
Applications: BioassayMM Capeling et al. (2022-02-15), Suspension culture promotes serosal mesothelial development in human intestinal organoids Cell Reports, 2022-038(7):110379.
PMID: 35172130 -
Species: Human
Sample Types: Protein
Applications: Pull-Down AssayK Kerekes et al. (2021-12-10), Wnt Inhibitory Factor 1 Binds to and Inhibits the Activity of Sonic Hedgehog Cells, 2021-110(12).
PMID: 34944004 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayAM Earley et al. (2021-11-15), Identification of ASCL1 as a determinant for human iPSC-derived dopaminergic neurons Scientific Reports, 2021-111(1):22257.
PMID: 34782629 -
Species: Human
Sample Types: Whole Cells
Applications: Cell CultureA Azatyan et al. (2021-10-13), Circular RNAs in Hedgehog Signaling Activation and Hedgehog-Mediated Medulloblastoma Tumors Cancers, 2021-113(20).
PMID: 34680287 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayK Nakai et al. (2021-07-29), In vitro monitoring of HTR2A-positive neurons derived from human-induced pluripotent stem cells Scientific Reports, 2021-011(1):15437.
PMID: 34326453 -
Species: Human
Sample Types: Organoid
Applications: BioassayJS Fleck et al. (2021-03-11), Resolving organoid brain region identities by mapping single-cell genomic data to reference atlases Cell Stem Cell, 2021-00(0).
PMID: 33711282 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayL Cui et al. (2020-12-03), Mutations of MAP1B encoding a microtubule-associated phosphoprotein cause sensorineural hearing loss JCI Insight, 2020-15(23).
PMID: 33268592 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayJL Goggi et al. (2020-08-08), Dopamine transporter neuroimaging accurately assesses the maturation of dopamine neurons in a preclinical model of Parkinson's disease Stem Cell Res Ther, 2020-011(1):347.
PMID: 32771055 -
Species: Mouse
Sample Types: Whole Cells
Applications: BioassayCR Cochrane et al. (2020-08-03), Trp53 and Rb1 regulate autophagy and ligand-dependent Hedgehog signaling J. Clin. Invest., 2020-00(0).
PMID: 32568216 -
Species: Human
Applications: Cell CultureC Yang et al. (2020-05-14), Genetic landscape and ligand-dependent activation of sonic hedgehog-Gli1 signaling in chordomas: a novel therapeutic target Oncogene, 2020-00(0).
PMID: 32404987 -
Species: Human
Sample Types: Whole Cells
Applications: Cell CultureCT Hong et al. (2020-03-17), Insulin Resistance Promotes Parkinson's Disease through Aberrant Expression of &alpha-Synuclein, Mitochondrial Dysfunction, and Deregulation of the Polo-Like Kinase 2 Signaling Cells, 2020-09(3).
PMID: 32192190 -
Species: Porcine
Sample Types: In Vivo
Applications: In VivoB Ghaleh et al. (2020-03-04), Cardioprotective effect of sonic hedgehog ligand in pig models of ischemia reperfusion Theranostics, 2020-010(9):4006-4016.
PMID: 32226535 -
Species: Human
Sample Types: Whole Cells
Applications: BioassaySL Boddy et al. (2020-03-01), Generation of Otic Lineages from Integration-Free Human-Induced Pluripotent Stem Cells Reprogrammed by mRNAs Stem Cells Int, 2020-02020(0):3692937.
PMID: 32190057 -
Species: Mouse
Sample Types: Whole Cells
Applications: BioassayJ Ferent et al. (2019-12-10), The Ciliary Protein Arl13b Functions Outside of the Primary Cilium in Shh-Mediated Axon Guidance Cell Rep, 2019-129(11):3356-3366.e3.
PMID: 31825820 -
Species: Mouse
Sample Types: Whole Cells
Applications: BioassayWW Feng et al. (2019-12-10), CD36-Mediated Metabolic Rewiring of Breast Cancer Cells Promotes Resistance to HER2-Targeted Therapies Cell Rep, 2019-129(11):3405-3420.e5.
PMID: 31825825 -
Species: Mouse
Sample Types: Whole Cells
Applications: Cell CultureCL White et al. (2019-11-01), A Sexually Dimorphic Role for STAT3 in Sonic Hedgehog Medulloblastoma Cancers (Basel), 2019-111(11).
PMID: 31683879 -
Species: Rat
Sample Types: Whole Cells
Applications: BioassayJP Zanin et al. (2019-10-03), The p75NTR influences cerebellar circuit development and adult behavior via regulation of cell cycle duration of granule cell progenitors J. Neurosci., 2019-10(0).
PMID: 31582529 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayS Park et al. (2019-06-01), Differentiation of Motor Neuron-Like Cells from Tonsil-Derived Mesenchymal Stem Cells and Their Possible Application to Neuromuscular Junction Formation Int J Mol Sci, 2019-020(11).
PMID: 31159418 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayL Ma et al. (2019-05-02), WNT/NOTCH Pathway Is Essential for the Maintenance and Expansion of Human MGE Progenitors Stem Cell Reports, 2019-00(0).
PMID: 31056478 -
Species: Human
Sample Types: Whole Cells
Applications: BioassaySK Riaz et al. (2019-04-29), Influence of SHH/GLI1 axis on EMT mediated migration and invasion of breast cancer cells Sci Rep, 2019-09(1):6620.
PMID: 31036836 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayJ Ooi et al. (2019-02-26), Unbiased Profiling of Isogenic Huntington Disease hPSC-Derived CNS and Peripheral Cells Reveals Strong Cell-Type Specificity of CAG Length Effects Cell Rep, 2019-026(9):2494-2508.e7.
PMID: 30811996 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayM Elkouris et al. (2019-02-22), Long Non-coding RNAs Associated With Neurodegeneration-Linked Genes Are Reduced in Parkinson's Disease Patients Front Cell Neurosci, 2019-013(0):58.
PMID: 30853899 -
C Lang et al. (2018-11-29), Single-Cell Sequencing of iPSC-Dopamine Neurons Reconstructs Disease Progression and Identifies HDAC4 as a Regulator of Parkinson Cell Phenotypes Cell Stem Cell, 2018-10(0).
PMID: 30503143 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayKKB Tan et al. (2018-06-22), Sequential Application of Discrete Topographical Patterns Enhances Derivation of Functional Mesencephalic Dopaminergic Neurons from Human Induced Pluripotent Stem Cells Sci Rep, 2018-08(1):9567.
PMID: 29934644 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayC Xu et al. (2018-06-04), High expression of Sonic hedgehog in allergic airway epithelia contributes to goblet cell metaplasia Mucosal Immunol, 2018-00(0).
PMID: 29867080 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayX Hu et al. (2018-05-02), Efficient induction of functional ameloblasts from human keratinocyte stem cells Stem Cell Res Ther, 2018-09(1):126.
PMID: 29720250 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayJY Kim et al. (2018-04-13), Wnt signal activation induces midbrain specification through direct binding of the beta-catenin/TCF4 complex to the EN1 promoter in human pluripotent stem cells Exp. Mol. Med., 2018-050(4):24.
PMID: 29650976 -
Species: Rat
Sample Types: Whole Cells
Applications: BioassayG Shall et al. (2018-03-02), Effects of Passage Number and Differentiation Protocol on the Generation of Dopaminergic Neurons from Rat Bone Marrow-Derived Mesenchymal Stem Cells Int J Mol Sci, 2018-019(3).
PMID: 29498713 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayX Ye et al. (2018-03-02), PM2.5 promotes human bronchial smooth muscle cell migration via the sonic hedgehog signaling pathway Respir. Res., 2018-019(1):37.
PMID: 29499705 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayC Chen et al. (2018-03-01), Sonic hedgehog signaling pathway promotes INSM1 transcription factor in neuroendocrine lung cancer Cell. Signal., 2018-046(0):83-91.
PMID: 29501727 -
Species: Mouse
Sample Types: Whole Cells
Applications: BioassayDM Fink et al. (2017-12-26), Coordinated d-cyclin/Foxd1 activation drives mitogenic activity of Sonic Hedgehog signaling pathway Cell. Signal., 2017-10(0).
PMID: 29284139 -
Species: Human
Sample Types: Whole Cells
Applications: BioassaySY Xie et al. (2017-11-23), RKIP reduction enhances radioresistance by activating the Shh signaling pathway in non-small-cell lung cancer Onco Targets Ther, 2017-110(0):5605-5619.
PMID: 29200875 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayDJM Bergen et al. (2017-08-15), The Golgi matrix protein giantin is required for normal cilia function in zebrafish Biol Open, 2017-00(0).
PMID: 28546340 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayS Kasiri et al. (2017-06-26), GLI1 blockade potentiates the antitumor activity of PI3K antagonists in lung squamous cell carcinoma Cancer Res., 2017-00(0).
PMID: 28652248 -
Species: Bovine
Sample Types: Whole Cells
Applications: BioassayL J Spicer (2016-12-11), G protein-coupled receptor 34 in ovarian granulosa cells of cattle: changes during follicular development and potential functional implications Domest. Anim. Endocrinol, 2016-159(0):90-99.
PMID: 28040605 -
Species: Human
Sample Types: Whole Cells
Applications: Bioassay(2016-11-21), Developmental Reprogramming in Mesenchymal Stromal Cells of Human Subjects with Idiopathic Pulmonary Fibrosis Sci Rep, 2016-16(0):37445.
PMID: 27869174 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayHai Zhang (2016-10-31), Anti-proliferation of breast cancer cells with itraconazole: Hedgehog pathway inhibition induces apoptosis and autophagic cell death Cancer Lett., 2016-10(0).
PMID: 27810405 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayMatevossian A et al. (2015-04-01), Hedgehog Acyltransferase as a target in estrogen receptor positive, HER2 amplified, and tamoxifen resistant breast cancer cells. Mol Cancer, 2015-014(0):72.
PMID: 25889650 -
Species: Xenopus
Sample Types: Embryo
Applications: BioassayBelgacem Y et al. (2015-03-17), Inversion of Sonic hedgehog action on its canonical pathway by electrical activity. Proc Natl Acad Sci U S A, 2015-0112(13):4140-5.
PMID: 25829542 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayTang C et al. (2015-01-10), Hedgehog signaling stimulates the conversion of cholesterol to steroids. Cell Signal, 2015-027(3):487-97.
PMID: 25582983 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayHartfield et al. (2014-02-21), Physiological characterisation of human iPS-derived dopaminergic neurons. PLoS ONE, 2014-09(2):e87388.
PMID: 24586273 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayWilliams E et al. (2014-01-12), Mutant astrocytes differentiated from Rett syndrome patients-specific iPSCs have adverse effects on wild-type neurons. Hum Mol Genet, 2014-023(11):2968-80.
PMID: 24419315 -
Species: Human
Sample Types: Cell Culture Supernates
Applications: BioassaySaito A et al. (2013-12-12), Chondrocyte proliferation regulated by secreted luminal domain of ER stress transducer BBF2H7/CREB3L2. Mol Cell, 2013-153(1):127-39.
PMID: 24332809 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayChen et al. (2013-04-22), Better prognosis of patients with glioma expressing FGF2-dependent PDGFRA irrespective of morphological diagnosis. PLoS ONE, 2013-08(4):e61556.
PMID: 23630597 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayLiu Y et al. (2013-04-21), Medial ganglionic eminence-like cells derived from human embryonic stem cells correct learning and memory deficits. Nat Biotechnol, 2013-031(5):440-7.
PMID: 23604284 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayCai J et al. (2013-01-23), BMP and TGF-beta pathway mediators are critical upstream regulators of Wnt signaling during midbrain dopamine differentiation in human pluripotent stem cells. Dev Biol, 2013-0376(1):62-73.
PMID: 23352789 -
Species: Mouse
Sample Types: Whole Cells
Applications: BioassayStrand MF et al. (2011-06-15), A novel synthetic smoothened antagonist transiently inhibits pancreatic adenocarcinoma xenografts in a mouse model. PLoS ONE, 2011-06(6):e19904.
PMID: 21698280 -
Species: Mouse
Sample Types: Whole Tissue
Applications: BioassayFabre PJ et al. (2010-01-06), Segregation of ipsilateral retinal ganglion cell axons at the optic chiasm requires the Shh receptor Boc. J. Neurosci., 2010-030(0):266.
PMID: 20053908 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayKiprilov EN et al. (2008-03-10), Human embryonic stem cells in culture possess primary cilia with hedgehog signaling machinery. J. Cell Biol., 2008-0180(5):897-904.
PMID: 18332216
There are no citations that match your criteria.
Customer Reviews for Recombinant Human Sonic Hedgehog/Shh (C24II) N-Terminus (4)
5 out of 5
4 customer
ratings
Customer Images
Showing
1
-
4 of
4 reviews
Showing All
Filter By:
-
Application: Stem/Immune cell maintenance or differentiationVerified Customer | Posted 04/10/2019
-
Application: Cell ProliferationVerified Customer | Posted 11/02/2017Granule cells of cerebellum culture for 24 hs in the presence of 100 ng/ml of Shh.
-
Application: In vivo studyVerified Customer | Posted 05/13/2016
-
Application: Cell ProliferationVerified Customer | Posted 05/12/2016
There are no reviews that match your criteria.
FAQs for Recombinant Human Sonic Hedgehog/Shh (C24II) N-Terminus
Showing
1
-
1 of
1 FAQ
Showing All
-
Q: What is the difference between Recombinant Human Sonic Hedgehog Catalog # 1845-SH and Catalog # 1314-SH?
A: Recombinant Human Sonic Hedgehog, Catalog # 1845-SH, possesses a N-terminal mutation that increases its potency in bioassay tests. The amino acid sequence is Cys24-Gly197 (Cys24Ile-Ile), accession number NP_000184. The Cys24Ile-Ile mutation was created to match a publication that describes enhanced activity with these modifications: "http://www.ncbi.nlm.nih.gov/pubmed/11284692". Catalog # 1314-SH does not possess this mutation.
Loading...
