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PAR2 Products

Protease-Activated Receptor 2 (PAR2) is a protease activated 7-transmembrane G-protein-coupled receptor. Human PAR2 contains a cleavage site for trypsin, mast cell tryptase or coagulation factor VIIa or Xa, 11 amino acids (aa) C-terminal to the signal sequence. Cleavage creates a tethered ligand that activates the 361 aa receptor. PAR2 is expressed in kidney, pancreas, stomach, intestine, airway, skin, bladder and brain; activation stimulates release of inflammatory and nociceptive mediators. PAR2 is downregulated by ubiquination, endocytosis and degradation. Mature human PAR2 shows 78% amino acid identity with mouse PAR2 over the extracellular portions.

22 results for "PAR2" in Products

PAR2 Products

Protease-Activated Receptor 2 (PAR2) is a protease activated 7-transmembrane G-protein-coupled receptor. Human PAR2 contains a cleavage site for trypsin, mast cell tryptase or coagulation factor VIIa or Xa, 11 amino acids (aa) C-terminal to the signal sequence. Cleavage creates a tethered ligand that activates the 361 aa receptor. PAR2 is expressed in kidney, pancreas, stomach, intestine, airway, skin, bladder and brain; activation stimulates release of inflammatory and nociceptive mediators. PAR2 is downregulated by ubiquination, endocytosis and degradation. Mature human PAR2 shows 78% amino acid identity with mouse PAR2 over the extracellular portions.

22 results for "PAR2" in Products

Flow, CyTOF-ready
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Catalog #: FAB3949N
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Catalog #: FAB3949U
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Catalog #: FAB3949R
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Catalog #: FAB3949T
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Catalog #: FAB3949S
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Catalog #: FAB3949G
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Catalog #: RDC0166
Catalog #: FAB3949V
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Potent and selective PAR2 agonist

PAR2 receptor agonist

PAR2-activating peptide

Potent and selective PAR2 agonist

PAR2 peptide antagonist

PAR2 receptor agonist

Potent PAR2 biased agonist; exhibits bias for ERK1/2 signaling

Potent PAR2 biased agonist; exhibits bias for Ca2+ signaling

Control peptide for SLIGRL-NH2 (Cat. No. 1468)

Control peptide for SLIGKV-NH2 (Cat. No. 3010)

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