AC 264613

Name: AC 264613
Brand: Tocris Bioscience
SKU: 3370

Tocris Bioscience, part of Bio-Techne | Catalog # 3370

Citations (7)

COA / SDS

PAR2 receptor agonist

Key Product Details

Description:	PAR₂ receptor agonist
Chemical Name:	(±)-(3R,4S)-2-Oxo-4-phenyl-3-pyrollidinecarboxylic acid 2-[1-(3-bromophenyl)ethylidene]hydrazide
Purity:	≥98% (HPLC)
Molecular Weight:	400.27

View Full Technical Details for AC 264613

Technical Data
Citations

Biological Activity for AC 264613

AC 264613 is a potent and selective protease-activated receptor 2 (PAR₂) agonist (pEC₅₀ = 7.5). Displays no activity at other PAR subtypes and exhibits no significant activity at over 30 other receptors implicated in nociception and inflammation. Stimulates PI hydrolysis, Ca²⁺ mobilization and cellular proliferation in vitro (pEC₅₀ values are 6.9, 7.0 and 7.5 respectively).

Compound Libraries for AC 264613

AC 264613 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for AC 264613

M. Wt	400.27
Formula	C₁₉H₁₈BrN₃O₂
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1051487-82-1
PubChem ID	25108278
InChi Key	RQKXQCSEZPQBNZ-QSBCOWLBSA-N
Smiles	O=C1[C@@H]([C@](N/N=C(C)/C3=CC=CC(Br)=C3)=O)[C@H]([C@]2=CC=CC=C2)CN1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for AC 264613

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	40.03	100

Preparing Stock Solutions for AC 264613

The following data is based on the product molecular weight 400.27.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.50 mL	12.49 mL	24.98 mL
5 mM	0.50 mL	2.50 mL	5.00 mL
10 mM	0.25 mL	1.25 mL	2.50 mL
50 mM	0.05 mL	0.25 mL	0.50 mL

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References for AC 264613

References are publications that support the biological activity of the product.

Seitzberg Discovery of potent and selective small-molecule PAR-2 agonists. J.Med.Chem. 2008 PMID: 18720984
Gardell Identification and characterization of novel small-molecule protease-activated receptor 2 agonists. J.Pharmacol.Exp.Ther. 2008 PMID: 18768780