2-Furoyl-LIGRLO-amide

Name: 2-Furoyl-LIGRLO-amide
Brand: Tocris Bioscience
SKU: 3015
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 3015

(1)

Citations (3)

COA / SDS

Potent and selective PAR2 agonist

Key Product Details

Description:	Potent and selective PAR₂ agonist
Purity:	≥95% (HPLC)
Molecular Weight:	777.96

View Full Technical Details for 2-Furoyl-LIGRLO-amide

Technical Data
Citations / Reviews (1)

Biological Activity for 2-Furoyl-LIGRLO-amide

2-Furoyl-LIGRLO-amide is a potent and selective PAR₂ receptor agonist (pD₂ = 7.0). Causes a dose-dependent relaxation of murine femoral arteries.

Technical Data for 2-Furoyl-LIGRLO-amide

M. Wt	777.96
Formula	C₃₆H₆₃N₁₁O₈
Single Letter Sequence	LIGRLX (Modifications: Leu-1 = 2-Furoyl-Leu, X = Orn & C-terminal amide)
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	729589-58-6
PubChem ID	10395438
InChi Key	OSKIRYSKGDEIOG-WTWMNNMUSA-N
Smiles	[H]N([C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN)C(N)=O)C(=O)C1=CC=CO1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for 2-Furoyl-LIGRLO-amide

Solubility

Soluble to 1mg/ml in water

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References for 2-Furoyl-LIGRLO-amide

References are publications that support the biological activity of the product.

Alshurafa A protease activated receptor-2 (PAR-2) activating peptide, tc-LIGRLO-NH₂, induces protease release from mast cells: role in TNF degradation. BMC Pharmacol. 2004 PMID: 15265236
Olianas Proteinase-activated receptors 1 and 2 in rat olfactory system: layer-specific regulation of multiple signaling pathways in the main olfactory bulb and induction of neurite retraction in olfactory sensory neurons. Neuroscience 2007 PMID: 17434682
McGuire 2-Furoyl-LIGRLO-amide: a potent and selective proteinase-activated receptor 2 agonist. J.Pharmacol.Exp.Ther. 2004 PMID: 14976230