2-Furoyl-LIGRLO-amide

Name: 2-Furoyl-LIGRLO-amide
Brand: Tocris Bioscience
SKU: 3015
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 3015

(1)

Citations (5)

COA / SDS

Potent and selective PAR2 agonist

100% Guarantee

Product Description
Product Specifications
Solubility
Calculators
Background References
Product Documents
Specific Notices

Key Product Details

Description

Potent and selective PAR2 agonist

View all Protease-Activated Receptor Agonists »

Product Description

2-Furoyl-LIGRLO-amide is a potent and selective PAR₂ receptor agonist (pD₂ = 7.0). Causes a dose-dependent relaxation of murine femoral arteries.

Product Specifications

Molecular Weight

777.96

Formula

C₃₆H₆₃N₁₁O₈

Storage

Store at -20°C

Purity

≥95% (HPLC)

CAS Number

729589-58-6

PubChem ID

10395438

InChI Key

OSKIRYSKGDEIOG-WTWMNNMUSA-N

SMILES

[H]N([C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN)C(N)=O)C(=O)C1=CC=CO1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Soluble to 1mg/ml in water

Calculators

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

Background References

References are publications that support the biological activity of the product.

Alshurafa A protease activated receptor-2 (PAR-2) activating peptide, tc-LIGRLO-NH₂, induces protease release from mast cells: role in TNF degradation. BMC Pharmacol. 2004 PMID: 15265236
Olianas Proteinase-activated receptors 1 and 2 in rat olfactory system: layer-specific regulation of multiple signaling pathways in the main olfactory bulb and induction of neurite retraction in olfactory sensory neurons. Neuroscience 2007 PMID: 17434682
McGuire 2-Furoyl-LIGRLO-amide: a potent and selective proteinase-activated receptor 2 agonist. J.Pharmacol.Exp.Ther. 2004 PMID: 14976230