FSLLRY-NH2

Name: FSLLRY-NH2
Brand: Tocris Bioscience
SKU: 4751
Rating: 4 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 4751

Citations (38)

COA / SDS

PAR2 peptide antagonist

Key Product Details

Description:	PAR₂ peptide antagonist
Purity:	≥95% (HPLC)
Molecular Weight:	796.97

View Full Technical Details for FSLLRY-NH2

Technical Data
Citations

Biological Activity for FSLLRY-NH2

FSLLRY-NH2 is a selective PAR₂ peptide antagonist. Reverses taxol-induced mechanical allodynia, heat hyperalgesia and PKC activation in ICR mice. Blocks ERK activation and collagen production in isolated cardiac fibroblasts. Also reduces symptoms in a mouse model of dermatophyte-associated itch. FSLLRY-NH2 inhibits C. albicans induced inflammation in oral mucosal cells in vitro.

Technical Data for FSLLRY-NH2

M. Wt	796.97
Formula	C₃₉H₆₀N₁₀O₈
Single Letter Sequence	FSLLRY (Modifications: Tyr-6 = C-terminal amide)
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	245329-02-6
PubChem ID	73352412
InChi Key	KMSCNWHRNILNRJ-JNRWAQIZSA-N
Smiles	[H]N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for FSLLRY-NH2

Solubility

Soluble to 1mg/ml in water

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References for FSLLRY-NH2

References are publications that support the biological activity of the product.

Kumar Candida albicans Sap6 initiates oral mucosal inflammation via the protease activated receptor PAR2. Front.Immunol. 2022 PMID: 35844627
Chen Proteinase-activated receptor 2 sensitizes transient receptor potential vanilloid 1, transient receptor potential vanilloid 4, and transient receptor potential ankyrin 1 in PacT.-induced neuropathic pain. Neuroscience 2011 PMID: 21763756
Andoh Involvement of serine protease and proteinase-activated receptor 2 in dermatophyte-associated itch in mice. J.Pharmacol.Exp.Ther. 2012 PMID: 22761302
McLarty Tryptase/protease-activated receptor 2 interactions induce selective mitogen-activated protein kinase signaling and collagen synthesis by cardiac fibroblasts. Hypertension 2011 PMID: 21730297