Neprilysin/CD10 Products
The neprilysin (NEP) family of zinc metallopeptidases includes neprilysin, endothelin-converting enzyme-2 (ECE-2), PEX, damage induced neuronal endopeptidase (DINE), Kell and several neprilysin-like proteins. Neprilysin is expressed at the cell surface of a variety of cell types. Enzymatically, neprilysin functions both as an endopeptidase with a thermolysin-like specificity and as a dipeptidylcarboxypeptidase. Neprilysin has been shown to be involved in the degradation of enkephalins in the mammalian brain and the inactivation of circulating atrial natriuretic peptide. Neprilysin has also been identified as the common acute lymphoblastic leukemia antigen (CALLA), and to be expressed on the surface of lymphocytes in some disease states. These and other observations have resulted in considerable clinical interest in neprilysin as a potential target for analgesics and antihypertensive drugs. Neprilysin is also a major degrading enzyme of amyloid-beta peptide (A-beta) in the brain, indicating that down-regulation of neprilysin activity, which could be caused by aging, can contribute to the development of Alzheimers disease by promoting A-beta accumulation.
31 results for "Neprilysin/CD10" in Products
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Neprilysin/CD10 Products
The neprilysin (NEP) family of zinc metallopeptidases includes neprilysin, endothelin-converting enzyme-2 (ECE-2), PEX, damage induced neuronal endopeptidase (DINE), Kell and several neprilysin-like proteins. Neprilysin is expressed at the cell surface of a variety of cell types. Enzymatically, neprilysin functions both as an endopeptidase with a thermolysin-like specificity and as a dipeptidylcarboxypeptidase. Neprilysin has been shown to be involved in the degradation of enkephalins in the mammalian brain and the inactivation of circulating atrial natriuretic peptide. Neprilysin has also been identified as the common acute lymphoblastic leukemia antigen (CALLA), and to be expressed on the surface of lymphocytes in some disease states. These and other observations have resulted in considerable clinical interest in neprilysin as a potential target for analgesics and antihypertensive drugs. Neprilysin is also a major degrading enzyme of amyloid-beta peptide (A-beta) in the brain, indicating that down-regulation of neprilysin activity, which could be caused by aging, can contribute to the development of Alzheimers disease by promoting A-beta accumulation.
31 results for "Neprilysin/CD10" in Products
Design and order Simple Plex cartridges tailor made to meet your needs with customizable Simple Plex Assay panels for the Ella platform.
Contains 4 membranes - each spotted in duplicate with 35 different protease antibodies
Contains 4 membranes-each spotted in duplicate with 79 different cytokine antibodies
Contains 4 membranes-2 spotted in duplicate with antibodies against 35 different proteases and 2 spotted in duplicate with antibodies against 32 different protease inhibitors
Neutral endopeptidase and endothelin converting enzyme inhibitor
Chemical Name : | N-[N-[[(6-Deoxy-α-L-mannopyranosyl)oxy]hydroxyphosphinyl]-L-leucyl]-L-tryptophan disodium salt |
Purity : | ≥95% (HPLC) |
Assay Range : | 125 - 8,000 pg/mL |
Applications : | ELISA |
Membrane metallo-endopeptidase (neprilysin) inhibitor prodrug; orally bioavailable
Alternate Names : | AHU 377 |
Chemical Name : | Ethyl (αR,γS)-γ-[(3-carboxy-1-oxopropyl)amino]-α-methyl-[1,1'-biphenyl]-4-pentanoate hemicalcium salt |
Purity : | ≥98% (HPLC) |
Source : | CHO |
Accession # : | AAA37386 |
Applications : | Enzyme Activity |
Simple Plex Human Neprilysin/CD10 assay kit for use on Ella instrument. Contains cartridge, sample diluent SD13, and wash buffer.
Create your custom Simple Plex cartridge for up to 8 targets. Choose from more than 250 targets across multiple species.
Assay Range : | 93.8 - 6,000 pg/mL |
Applications : | ELISA |
Clonality : | Monoclonal |
Host : | Rat IgG2b Clone #200103 |
Applications : | Immunohistochemistry, Western Blot |
Clonality : | Monoclonal |
Host : | Mouse IgG2b Clone #212504 |
Applications : | CyTOF-ready, Flow Cytometry, Western Blot |
Clonality : | Polyclonal |
Host : | Goat IgG |
Applications : | ELISA Detection, Flow Cytometry, Immunohistochemistry, Western Blot |
Clonality : | Polyclonal |
Host : | Goat IgG |
Applications : | ELISA Detection, Western Blot |
Clonality : | Polyclonal |
Host : | Goat IgG |
Applications : | CyTOF-ready, ELISA Capture, Flow Cytometry, Immunohistochemistry, Immunoprecipitation, Western Blot |
Clonality : | Polyclonal |
Host : | Goat IgG |
Applications : | ELISA Capture, Immunohistochemistry, Immunoprecipitation, Western Blot |
Clonality : | Monoclonal |
Host : | Mouse IgG2b Clone #715820 |
Applications : | Immunohistochemistry, Western Blot |
Source : | CHO |
Accession # : | P08473 |
Applications : | Enzyme Activity |
Clonality : | Monoclonal |
Host : | Mouse IgG2b Clone #715823 |
Applications : | Immunohistochemistry, Western Blot |
Clonality : | Monoclonal |
Host : | Mouse IgG2b Clone #212504 |
Applications : | Flow Cytometry |
Clonality : | Monoclonal |
Host : | Mouse IgG2b Clone #212504 |
Applications : | Flow Cytometry |
Clonality : | Monoclonal |
Host : | Mouse IgG2b Clone #212504 |
Applications : | Flow Cytometry |