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Neprilysin/CD10 Products

The neprilysin (NEP) family of zinc metallopeptidases includes neprilysin, endothelin-converting enzyme-2 (ECE-2), PEX, damage induced neuronal endopeptidase (DINE), Kell and several neprilysin-like proteins. Neprilysin is expressed at the cell surface of a variety of cell types. Enzymatically, neprilysin functions both as an endopeptidase with a thermolysin-like specificity and as a dipeptidylcarboxypeptidase. Neprilysin has been shown to be involved in the degradation of enkephalins in the mammalian brain and the inactivation of circulating atrial natriuretic peptide. Neprilysin has also been identified as the common acute lymphoblastic leukemia antigen (CALLA), and to be expressed on the surface of lymphocytes in some disease states. These and other observations have resulted in considerable clinical interest in neprilysin as a potential target for analgesics and antihypertensive drugs. Neprilysin is also a major degrading enzyme of amyloid-beta peptide (A-beta) in the brain, indicating that down-regulation of neprilysin activity, which could be caused by aging, can contribute to the development of Alzheimers disease by promoting A-beta accumulation.

31 results for "Neprilysin/CD10" in Products

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Neprilysin/CD10 Products

The neprilysin (NEP) family of zinc metallopeptidases includes neprilysin, endothelin-converting enzyme-2 (ECE-2), PEX, damage induced neuronal endopeptidase (DINE), Kell and several neprilysin-like proteins. Neprilysin is expressed at the cell surface of a variety of cell types. Enzymatically, neprilysin functions both as an endopeptidase with a thermolysin-like specificity and as a dipeptidylcarboxypeptidase. Neprilysin has been shown to be involved in the degradation of enkephalins in the mammalian brain and the inactivation of circulating atrial natriuretic peptide. Neprilysin has also been identified as the common acute lymphoblastic leukemia antigen (CALLA), and to be expressed on the surface of lymphocytes in some disease states. These and other observations have resulted in considerable clinical interest in neprilysin as a potential target for analgesics and antihypertensive drugs. Neprilysin is also a major degrading enzyme of amyloid-beta peptide (A-beta) in the brain, indicating that down-regulation of neprilysin activity, which could be caused by aging, can contribute to the development of Alzheimers disease by promoting A-beta accumulation.

31 results for "Neprilysin/CD10" in Products

Contains 4 membranes - each spotted in duplicate with 35 different protease antibodies

Contains 4 membranes-each spotted in duplicate with 79 different cytokine antibodies

Contains 4 membranes-2 spotted in duplicate with antibodies against 35 different proteases and 2 spotted in duplicate with antibodies against 32 different protease inhibitors

Neutral endopeptidase and endothelin converting enzyme inhibitor

Membrane metallo-endopeptidase (neprilysin) inhibitor prodrug; orally bioavailable

EnzAct
Catalog #: 898987

Control for use with Human Neprilysin/CD10 Simple Plex Cartridge Kit

Simple Plex Human Neprilysin/CD10 assay kit for use on Ella instrument. Contains cartridge, sample diluent SD13, and wash buffer.

WB, Flow, CyTOF-ready
WB, Flow, IHC
Catalog #: BAF1126
WB
WB, Flow, IHC, IP, CyTOF-ready
EnzAct
WB, IHC
Catalog #: FAB1182T
Flow
Catalog #: FAB1182U
Flow
Catalog #: FAB1182G
Flow
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