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Neprilysin/CD10: Antibodies

The neprilysin (NEP) family of zinc metallopeptidases includes neprilysin, endothelin-converting enzyme-2 (ECE-2), PEX, damage induced neuronal endopeptidase (DINE), Kell and several neprilysin-like proteins. Neprilysin is expressed at the cell surface of a variety of cell types. Enzymatically, neprilysin functions both as an endopeptidase with a thermolysin-like specificity and as a dipeptidylcarboxypeptidase. Neprilysin has been shown to be involved in the degradation of enkephalins in the mammalian brain and the inactivation of circulating atrial natriuretic peptide. Neprilysin has also been identified as the common acute lymphoblastic leukemia antigen (CALLA), and to be expressed on the surface of lymphocytes in some disease states. These and other observations have resulted in considerable clinical interest in neprilysin as a potential target for analgesics and antihypertensive drugs. Neprilysin is also a major degrading enzyme of amyloid-beta peptide (A-beta) in the brain, indicating that down-regulation of neprilysin activity, which could be caused by aging, can contribute to the development of Alzheimers disease by promoting A-beta accumulation.

352 results for "Neprilysin/CD10 Primary Antibodies" in Products

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Neprilysin/CD10: Antibodies

The neprilysin (NEP) family of zinc metallopeptidases includes neprilysin, endothelin-converting enzyme-2 (ECE-2), PEX, damage induced neuronal endopeptidase (DINE), Kell and several neprilysin-like proteins. Neprilysin is expressed at the cell surface of a variety of cell types. Enzymatically, neprilysin functions both as an endopeptidase with a thermolysin-like specificity and as a dipeptidylcarboxypeptidase. Neprilysin has been shown to be involved in the degradation of enkephalins in the mammalian brain and the inactivation of circulating atrial natriuretic peptide. Neprilysin has also been identified as the common acute lymphoblastic leukemia antigen (CALLA), and to be expressed on the surface of lymphocytes in some disease states. These and other observations have resulted in considerable clinical interest in neprilysin as a potential target for analgesics and antihypertensive drugs. Neprilysin is also a major degrading enzyme of amyloid-beta peptide (A-beta) in the brain, indicating that down-regulation of neprilysin activity, which could be caused by aging, can contribute to the development of Alzheimers disease by promoting A-beta accumulation.

352 results for "Neprilysin/CD10 Primary Antibodies" in Products

WB, Flow, IHC, IP, CyTOF-ready
WB, Flow, CyTOF-ready
Flow, IHC, WB
WB, Flow, IHC
WB, IHC
Catalog #: BAF1126
WB
Flow, IP

Clone MEM-78 was used by HLDA to establish CD designation.

ELISA, IHC, WB
Catalog #: FAB1182V
Flow
Catalog #: FAB1182R
Flow
Catalog #: FAB1182G
Flow
Catalog #: FAB1182T
Flow
Catalog #: FAB1182U
Flow
Catalog #: FAB1182N
Flow
Catalog #: FAB1182S
Flow
ELISA, IHC, WB
Flow, ICC/IF, IHC, WB

Recombinant Monoclonal Antibody

Flow, ICC/IF
Results Per Page
5 10 25 50
/ 15