MCT1/SLC16A1: Small Molecules and Peptides
MCT1/SLC16A1 is a proton-linked monocarboxylate transporter that catalyzes the movement of many monocarboxylates, such as lactate and pyruvate, across the plasma membrane. Mutations in this gene are associated with erythrocyte lactate transporter defect. SLC16A1 may be a potential therapeutic target combining antimetabolic and anti-angiogenic activities. SLC16A1 blockers could act as HIF-1 inhibitors leading to anti-angiogenic effects.
6 results for "MCT1/SLC16A1 Small Molecules and Peptides" in Products
6 results for "MCT1/SLC16A1 Small Molecules and Peptides" in Products
MCT1/SLC16A1: Small Molecules and Peptides
MCT1/SLC16A1 is a proton-linked monocarboxylate transporter that catalyzes the movement of many monocarboxylates, such as lactate and pyruvate, across the plasma membrane. Mutations in this gene are associated with erythrocyte lactate transporter defect. SLC16A1 may be a potential therapeutic target combining antimetabolic and anti-angiogenic activities. SLC16A1 blockers could act as HIF-1 inhibitors leading to anti-angiogenic effects.
MCT1 and MCT2 inhibitor; inhibits glycolysis in cancer cells
| Chemical Name: | 6-[(3,5-Dimethyl-1H-pyrazol-4-yl)methyl]-5-[[(4S)-4-hydroxy-2-isoxazolidinyl]carbonyl]-3-methyl-1-(2-methylpropyl)thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione |
| Purity: | ≥98% (HPLC) |
MCT1 inhibitor; also inhibits hexokinase II
| Chemical Name: | 3-Bromo-2-oxopropanoic acid |
Potent MCT1 inhibitor
| Chemical Name: | 2,6-Dihydro-7-[(3-hydroxypropyl)thio]-2-methyl-4-(2-methylpropyl)-6-(1-naphthalenylmethyl)-1H-pyrrolo[3,4-d]pyridazin-1one |
| Purity: | ≥98% (HPLC) |
MCT1 inhibitor
| Chemical Name: | 5-[[(3R)-3-Hydroxy-1-pyrrolidinyl]carbonyl]-3-methyl-1-(2-methylpropyl)-6-(4-quinolinylmethyl)thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione |
| Purity: | ≥98% (HPLC) |
MCT inhibitor; also inhibits mitochondrial pyruvate carrier
| Chemical Name: | 2-Cyano-3-(1-phenyl-1H-indol-3-yl)-2-propenoic acid |
| Purity: | ≥98% (HPLC) |
MCT inhibitor; decreases glycoloysis
| Chemical Name: | 2-Cyano-3-(4-hydroxyphenyl)-2-propenoic acid |
| Purity: | ≥98% (HPLC) |
