3-Bromopyruvate

Tocris Bioscience, part of Bio-Techne | Catalog # 7512

MCT1 inhibitor; also inhibits hexokinase II
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Key Product Details

Description

MCT1 inhibitor; also inhibits hexokinase II

View all Monocarboxylate Transporter Inhibitors »

Product Description

3-Bromopyruvate is a monocarboxylate transporter (MCT1) inhibitor (IC50 = 14.7 μM, 24.2 μM and 28.6 μM in SiHa, UM-UC-3, and HCT-116 human cancer cell lines, respectively). 3-Bromopyruvate shows antitumor activity in vitro and in vivo. 3-Bromopyruvate is also an inhibitor of hexokinase II, and decreases apoptosis in dopaminergic neurons in Parkinson's disease models in vitro and in vivo.

Product Specifications

Molecular Weight

166.96

Formula

C3H3BrO3

Storage

Store at -20°C

Chemical Name

3-Bromo-2-oxopropanoic acid

CAS Number

1113-59-3

PubChem ID

70684

InChI Key

PRRZDZJYSJLDBS-UHFFFAOYSA-N

SMILES

O=C(O)C(=O)CBr

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 16.7 100

Preparing Stock Solutions for 3-Bromopyruvate

The following data is based on the product molecular weight 166.96

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 5.99 mL 29.95 mL 59.89 mL
5 mM 1.20 mL 5.99 mL 11.98 mL
10 mM 0.60 mL 2.99 mL 5.99 mL
50 mM 0.12 mL 0.60 mL 1.20 mL

Calculators

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Reconstitution Calculator

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Background References

References are publications that support the biological activity of the product.

Product Documents for 3-Bromopyruvate

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for 3-Bromopyruvate

For research use only

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