AR-C 141990 hydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 5658
MCT1 inhibitor
Product Description
AR-C 141990 hydrochloride is a monocarboxylate transporter (MCT1) inhibitor (pKi = 7.6. Exhibits approximately 10-fold selectivity for MCT1 over MCT2 and no significant activity against MCT3 or 4. Inhibits graft versus host response and prolongs cardiac graft survival in a rat model. Immunosuppressant. Also inhibits brain penetration of GHB analog HOCPCA.Product Specifications
Molecular Weight
529.05
Formula
C26H28N4O4S.HCl
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
5-[[(3R)-3-Hydroxy-1-pyrrolidinyl]carbonyl]-3-methyl-1-(2-methylpropyl)-6-(4-quinolinylmethyl)thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione
CAS Number
2250019-94-2
PubChem ID
129316183
InChI Key
NFFGLQDNUHBVEY-UNTBIKODSA-N
SMILES
O=C(N1C[C@H](O)CC1)C2=C(CC3=C4C(C=CC=C4)=NC=C3)SC(N5CC(C)C)=C2C(N(C)C5=O)=O.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 49.26 | 100 | |
| DMSO | 49.26 | 100 |
Preparing Stock Solutions
for AR-C 141990 hydrochloride
The following data is based on the product molecular weight 529.05
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.89 mL | 9.45 mL | 18.90 mL |
| 5 mM | 0.38 mL | 1.89 mL | 3.78 mL |
| 10 mM | 0.19 mL | 0.95 mL | 1.89 mL |
| 50 mM | 0.04 mL | 0.19 mL | 0.38 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Thiesen In vitro and in vivo evidence for active brain uptake of the GHB analog HOCPCA by the monocarboxylate transporter subtype 1. J.Pharmacol.Exp.Ther. 2015 PMID: 25986445
- Påhlman Immunosuppressive properties of a series of novel inhibitors of the monocarboxylate transporter MCT-1. Transpl.Int. 2012 PMID: 23137339
Product Specific Notices for AR-C 141990 hydrochloride
For research use only
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