UK 5099
Tocris Bioscience, part of Bio-Techne | Catalog # 4186
MCT inhibitor; also inhibits mitochondrial pyruvate carrier
Key Product Details
Description
MCT inhibitor; also inhibits mitochondrial pyruvate carrier
Product Description
UK 5099 is an inhibitor of plasma membrane monocarboxylate transporters (MCTs) and the mitochondrial pyruvate carrier (MPC).Licensing Information
Sold for research purposes under agreement from Pfizer Inc.Product Specifications
Molecular Weight
288.30
Formula
C18H12N2O2
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
2-Cyano-3-(1-phenyl-1H-indol-3-yl)-2-propenoic acid
CAS Number
56396-35-1
PubChem ID
6438504
InChI Key
BIZNHCWFGNKBBZ-JLHYYAGUSA-N
SMILES
O=C(/C(C#N)=C/C2=CN(C3=CC=CC=C3)C1=CC=CC=C12)O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 28.83 | 100 |
Preparing Stock Solutions
for UK 5099
The following data is based on the product molecular weight 288.30
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.47 mL | 17.34 mL | 34.69 mL |
| 5 mM | 0.69 mL | 3.47 mL | 6.94 mL |
| 10 mM | 0.35 mL | 1.73 mL | 3.47 mL |
| 50 mM | 0.07 mL | 0.35 mL | 0.69 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Hildyard Identification of the mitochondrial pyruvate carrier in Saccharomyces cerevisiae. Biochem.J. 2003 PMID: 12887330
- Hinoi A molecular mechanism of pyruvate protection against cytotoxicity of reactive oxygen species in osteoblasts. Mol.Pharmacol. 2006 PMID: 16766717
- Wiemer The inhibition of pyruvate transport across the plasma membrane of the bloodstream form of Trypanosoma brucei and its metabolic implications. Biochem.J. 1995 PMID: 8526859
Product Specific Notices for UK 5099
For research use only
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